open access

Vol 62, No 4 (2003)
SHORT COMMUNICATIONS
Published online: 2003-09-05
Submitted: 2012-02-06
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The effect of calcitriol and its analogues on proliferation and hormone expression in cultured cells of thyroid medullary carcinomas

Maciej Zabel, Krzysztof Flig, Elżbieta Gębarowska, Joanna Surdyk-Zasada
Folia Morphol 2003;62(4):463-465.

open access

Vol 62, No 4 (2003)
SHORT COMMUNICATIONS
Published online: 2003-09-05
Submitted: 2012-02-06

Abstract

The study aimed at evaluating the effects of calcitriol and of its analogues on the proliferation of TT and rMTC cells (human and rat line tumour cells originating from thyroid medullary carcinoma) and at examining the effects of the substances on the secretion of the principal hormones of the cells, calcitonin (CT) and calcitonin gene-related peptide (CGRP). Cells of thyroid medullary carcinoma (human TT cells and rat rMTC cells) were cultured for 5 days in the absence or in the presence of calcitriol and of its two analogues (PRI-1906 and PRI-2191) in concentrations of 10-9 to 10-6 M. Calcitriol and the applied analogues weakly inhibited proliferation of thyroid medullary carcinoma in in vitro conditions. The evident effect of analogues on hormone secretion points to their effect on the process of CT gene expression.

Abstract

The study aimed at evaluating the effects of calcitriol and of its analogues on the proliferation of TT and rMTC cells (human and rat line tumour cells originating from thyroid medullary carcinoma) and at examining the effects of the substances on the secretion of the principal hormones of the cells, calcitonin (CT) and calcitonin gene-related peptide (CGRP). Cells of thyroid medullary carcinoma (human TT cells and rat rMTC cells) were cultured for 5 days in the absence or in the presence of calcitriol and of its two analogues (PRI-1906 and PRI-2191) in concentrations of 10-9 to 10-6 M. Calcitriol and the applied analogues weakly inhibited proliferation of thyroid medullary carcinoma in in vitro conditions. The evident effect of analogues on hormone secretion points to their effect on the process of CT gene expression.
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Keywords

calcitonin; CGRP; thyroid medullary carcinoma; calcitriol analogues

About this article
Title

The effect of calcitriol and its analogues on proliferation and hormone expression in cultured cells of thyroid medullary carcinomas

Journal

Folia Morphologica

Issue

Vol 62, No 4 (2003)

Pages

463-465

Published online

2003-09-05

Bibliographic record

Folia Morphol 2003;62(4):463-465.

Keywords

calcitonin
CGRP
thyroid medullary carcinoma
calcitriol analogues

Authors

Maciej Zabel
Krzysztof Flig
Elżbieta Gębarowska
Joanna Surdyk-Zasada

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