open access

Vol 62, No 4 (2003)
CASE REPORTS
Published online: 2003-09-05
Submitted: 2012-02-06
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Relations between Leu5-enkephalin- (LENK) and VIP-immunoreactive nerve fibres during human drug-resistant colitis. A case study

Barbara Kamińska, Sławomir Gonkowski, Maria Korzon, Agnieszka Bossowska, Piotr Landowski, Mariusz Majewski
Folia Morphol 2003;62(4):509-511.

open access

Vol 62, No 4 (2003)
CASE REPORTS
Published online: 2003-09-05
Submitted: 2012-02-06

Abstract

The double immunofluorescence technique was used to examine the distribution and interrelationship between LENK- and VIP-immunoreactive nerve fibres within the muscle layer and myenteric plexus of the large intestine in a young female patient (aged 17 years) suffering from colitis ulcerosa activa (CUA). As the CUA was found to be totally drug-resistant, a pancolotomy was performed by means of the Soave technique. Varicose nerve fibres, immunoreactive either to LENK or VIP, but not to both substances simultaneously, were found in all fragments of the bowel studied. A striking feature was their distribution pattern within the studied layers. In all cases LENK-IR fibres were closely accompanied by VIP-IR terminals. The density of the examined fibres depended on the bowel fragment studied, and was the greatest in the sigmoid colon, descending colon and rectum, while the lowest number was found in the caecum. The results of the present study may thus be indicative for the involvement of LENK- and VIPIR nerve fibres in the control of bowel functions during CUA, possibly on the basis of a "cross-talk" between terminals running in close vicinity to each other.

Abstract

The double immunofluorescence technique was used to examine the distribution and interrelationship between LENK- and VIP-immunoreactive nerve fibres within the muscle layer and myenteric plexus of the large intestine in a young female patient (aged 17 years) suffering from colitis ulcerosa activa (CUA). As the CUA was found to be totally drug-resistant, a pancolotomy was performed by means of the Soave technique. Varicose nerve fibres, immunoreactive either to LENK or VIP, but not to both substances simultaneously, were found in all fragments of the bowel studied. A striking feature was their distribution pattern within the studied layers. In all cases LENK-IR fibres were closely accompanied by VIP-IR terminals. The density of the examined fibres depended on the bowel fragment studied, and was the greatest in the sigmoid colon, descending colon and rectum, while the lowest number was found in the caecum. The results of the present study may thus be indicative for the involvement of LENK- and VIPIR nerve fibres in the control of bowel functions during CUA, possibly on the basis of a "cross-talk" between terminals running in close vicinity to each other.
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Keywords

colitis ulcerosa; enteric nervous system; plasticity; VIP; enkephalins; human

About this article
Title

Relations between Leu5-enkephalin- (LENK) and VIP-immunoreactive nerve fibres during human drug-resistant colitis. A case study

Journal

Folia Morphologica

Issue

Vol 62, No 4 (2003)

Pages

509-511

Published online

2003-09-05

Bibliographic record

Folia Morphol 2003;62(4):509-511.

Keywords

colitis ulcerosa
enteric nervous system
plasticity
VIP
enkephalins
human

Authors

Barbara Kamińska
Sławomir Gonkowski
Maria Korzon
Agnieszka Bossowska
Piotr Landowski
Mariusz Majewski

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