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AgNOR, Ki-67 and PCNA expression in fibroepithelial tumours of the breast in correlation with morphological features
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Abstract
In phyllodes tumours (PT), the AgNOR scores showed a tendency to increase with degrees of malignancy. There was significant correlation between Ag- NOR counts and proliferation rates as determined by Ki-67 and PCNA immunostaining. Ki-67 and PCNA expression correlated with mitotic count, stromal overgrowth, cellularity and atypia in PT. Determination of the AgNOR number per cell revealed an overlap between FA and PTLGM. The proliferating activity determined by immunohistochemistry with Ki-67 and PCNA antibodies did not reveal any significant difference between FA and PTLGM.
In summary, Ki-67 and PCNA expression is suggested as a marker of stromal element proliferation. The results obtained confirm the diagnostic difficulties in distinguishing PTLGM from FA of the cellular type using fine needle aspiration cytology.
Abstract
In phyllodes tumours (PT), the AgNOR scores showed a tendency to increase with degrees of malignancy. There was significant correlation between Ag- NOR counts and proliferation rates as determined by Ki-67 and PCNA immunostaining. Ki-67 and PCNA expression correlated with mitotic count, stromal overgrowth, cellularity and atypia in PT. Determination of the AgNOR number per cell revealed an overlap between FA and PTLGM. The proliferating activity determined by immunohistochemistry with Ki-67 and PCNA antibodies did not reveal any significant difference between FA and PTLGM.
In summary, Ki-67 and PCNA expression is suggested as a marker of stromal element proliferation. The results obtained confirm the diagnostic difficulties in distinguishing PTLGM from FA of the cellular type using fine needle aspiration cytology.
Keywords
AgNORs ; Ki-67; PCNA; fibroepithelial tumours of the breast
Title
AgNOR, Ki-67 and PCNA expression in fibroepithelial tumours of the breast in correlation with morphological features
Journal
Issue
Article type
Short communication
Pages
133-135
Published online
2003-12-03
Page views
570
Article views/downloads
1212
Bibliographic record
Folia Morphol 2004;63(1):133-135.
Keywords
AgNORs
Ki-67
PCNA
fibroepithelial tumours of the breast
Authors
Małgorzata Barwijuk-Machała
Bogusław Musiatowicz
Jacek Cylwik
Joanna Reszeć
Albert Augustynowicz