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Vol 63, No 2 (2004)
Short communication
Submitted: 2012-02-06
Published online: 2004-03-12
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Effect of acute exposure to cadmium on the expression of calcitonin gene-related peptide (CGRP), calcitonin (CT), somatostatin (SST) and synaptophysin (SYN) in the C cells of the rat thyroid - a preliminary study

Czykier E, Moniuszko-Jakoniuk J, Sawicki B
Folia Morphol 2004;63(2):217-220.

open access

Vol 63, No 2 (2004)
SHORT COMMUNICATIONS
Submitted: 2012-02-06
Published online: 2004-03-12

Abstract

The aim of the present study was to determine to what degree acute exposure to cadmium affects the expression of CGRP, CT, SST and SYN in the C cells of the rat thyroid. Animals from 7 experimental groups received CdCl2 iv. in doses of 3.5, 3, 2.5, 2, 1.5, 1 and 0.5 mg/kg b.w. respectively, while the control animals were given 0.9% NaCl iv. 24 hours after the iv. administration of CdCl2, a correlation was found between a single dose of cadmium and the intensity of the immunocytochemical reactions for CGRP, CT, SST and SYN in C cells of the rat thyroid when compared to the control. The weakest immunocytochemical reactions were noted in C cells of the thyroid of rats from Groups I and II, their intensity gradually increasing in Groups III, IV and V in comparison to the control. The reaction intensity in animals of Groups VI and VII resembled those of the control.

Abstract

The aim of the present study was to determine to what degree acute exposure to cadmium affects the expression of CGRP, CT, SST and SYN in the C cells of the rat thyroid. Animals from 7 experimental groups received CdCl2 iv. in doses of 3.5, 3, 2.5, 2, 1.5, 1 and 0.5 mg/kg b.w. respectively, while the control animals were given 0.9% NaCl iv. 24 hours after the iv. administration of CdCl2, a correlation was found between a single dose of cadmium and the intensity of the immunocytochemical reactions for CGRP, CT, SST and SYN in C cells of the rat thyroid when compared to the control. The weakest immunocytochemical reactions were noted in C cells of the thyroid of rats from Groups I and II, their intensity gradually increasing in Groups III, IV and V in comparison to the control. The reaction intensity in animals of Groups VI and VII resembled those of the control.

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Keywords

rat; thyroid gland; cadmium intoxication

About this article
Title

Effect of acute exposure to cadmium on the expression of calcitonin gene-related peptide (CGRP), calcitonin (CT), somatostatin (SST) and synaptophysin (SYN) in the C cells of the rat thyroid - a preliminary study

Journal

Folia Morphologica

Issue

Vol 63, No 2 (2004)

Article type

Short communication

Pages

217-220

Published online

2004-03-12

Page views

379

Article views/downloads

893

Bibliographic record

Folia Morphol 2004;63(2):217-220.

Keywords

rat
thyroid gland
cadmium intoxication

Authors

Czykier E
Moniuszko-Jakoniuk J
Sawicki B

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