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Urothelial cancer of the prostate gland. Immunohistochemical analysis of two cases of rare canine cancer
Affiliations- Department of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, C. K. Norwida 31, 50-375 Wroclaw, Poland
- Department of Veterinary Medicine, Università degli Studi di Milano, G. Celoria 10, 20133 Milan, Italy
- Department of Histology and Embryology, Wroclaw Medical University. Department of Physiotherapy, Wroclaw University School of Physical Education., T. Chałubińskiego 6a, 50-368 Wroclaw, Poland
- Department of Physiotherapy, Wroclaw University School of Physical Education, Wroclaw, Poland
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Abstract
Introduction. The study aimed to diagnose urothelial cancer of prostate gland (UCPG) in dogs as the primary focus and in its metastasis based on the expression of specific proteins used in immunohistochemical diagnosis of prostate cancer in men.
Material and methods. The study was carried out on specimens collected during a post-mortem examination from macroscopic lesions of the prostate glands from two dogs. The immunoexpression of the following proteins was verified: prostate-specific antigen (PSA), high molecular weight cytokeratins (HMWCK), cytokeratin 7 and 20 (CK-7,-20), E-cadherin, von Willebrand factor, cyclooxygenase-2 (COX-2), microsomal PGE2-1 synthase (mPGES-1) and component of the minichromosome 7 maintenance complex (MCM7).
Results. All markers, except for PSA, were expressed both at the primary tumour site and in the metastasis.
Conclusions. The immunohistochemical approach was more useful for the diagnosis of UCPG in dog than typical histopathological staining methods because it allowed for precise determination of features, type and grade of the tumour that may affect its early detection and treatment.
Abstract
Introduction. The study aimed to diagnose urothelial cancer of prostate gland (UCPG) in dogs as the primary focus and in its metastasis based on the expression of specific proteins used in immunohistochemical diagnosis of prostate cancer in men.
Material and methods. The study was carried out on specimens collected during a post-mortem examination from macroscopic lesions of the prostate glands from two dogs. The immunoexpression of the following proteins was verified: prostate-specific antigen (PSA), high molecular weight cytokeratins (HMWCK), cytokeratin 7 and 20 (CK-7,-20), E-cadherin, von Willebrand factor, cyclooxygenase-2 (COX-2), microsomal PGE2-1 synthase (mPGES-1) and component of the minichromosome 7 maintenance complex (MCM7).
Results. All markers, except for PSA, were expressed both at the primary tumour site and in the metastasis.
Conclusions. The immunohistochemical approach was more useful for the diagnosis of UCPG in dog than typical histopathological staining methods because it allowed for precise determination of features, type and grade of the tumour that may affect its early detection and treatment.
Keywords
canine; prostate; urothelial cancer; metastasis; cell markers; IHC
About this articleTitle
Urothelial cancer of the prostate gland. Immunohistochemical analysis of two cases of rare canine cancer
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Brief communication
Pages
272-277
Published online
2020-12-21
Page views
873
Article views/downloads
869
DOI
Pubmed
Bibliographic record
Folia Histochem Cytobiol 2020;58(4):272-277.
Keywords
canine
prostate
urothelial cancer
metastasis
cell markers
IHC
Authors
Rafal Ciaputa
Valeria Grieco
Izabela Janus
Malgorzata Kandefer-Gola
Piotr Dziegiel
Marcin Nowak
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