Vol 49, No 3 (2011)
Original paper
Submitted: 2012-01-05
Published online: 2011-10-28
Lobular neoplasia found on breast biopsy: marker of increased risk of malignancy or direct pre-cancerous lesion?
Bartłomiej Szynglarewicz, Rafał Matkowski, Agnieszka Hałoń, Piotr Kasprzak, Józef Forgacz, Iwona Gisterek, Jan Kornafel
DOI: 10.5603/FHC.2011.0059
·
Folia Histochem Cytobiol 2011;49(3):417-424.
Vol 49, No 3 (2011)
ORIGINAL PAPERS
Submitted: 2012-01-05
Published online: 2011-10-28
Abstract
The aim of this study was to compare the imaging symptoms and microscopic findings in females with lobular
neoplasia (LN) found on biopsy. 1,478 women who underwent primary open biopsy or surgical excision after percutaneous
biopsy were reviewed. In 24 of them (1.6%), LN was found. In four patients, excisional biopsy with hook-wire
localization was done primarily due to the radial scar. In 20 females, surgical excision of BIRADS 4 lesion was performed
because of the presence of LN in specimens from the vacuum-assisted or core-needle percutaneous biopsy.
Postoperative pathologic findings were compared to the radiological symptoms. In 13 women, LN did not produce
any radiological symptoms and was an additional histologic finding existing near the other lesion: fibroadenoma and
radial scar. In none of these lesions was an invasive cancer noticed. In one single patient, ductal carcinoma in situ was
observed in the other segment of the breast. Invasive ductal cancer developed in the contralateral breast in one patient.
In 11 patients, LN was diagnosed due to radiological symptoms produced by itself. In this group, the invasive lobular
cancer was found in seven lesions (64%). Our finding suggests that LN producing suspicious radiological symptoms
can be a different biologic type of this lesion when compared asymptomatic LN diagnosed which is usually found on
biopsy as additional microscopic pathology. Symptomatic LN is probably associated with a higher potential of malignant
transformation. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 417–424)
Abstract
The aim of this study was to compare the imaging symptoms and microscopic findings in females with lobular
neoplasia (LN) found on biopsy. 1,478 women who underwent primary open biopsy or surgical excision after percutaneous
biopsy were reviewed. In 24 of them (1.6%), LN was found. In four patients, excisional biopsy with hook-wire
localization was done primarily due to the radial scar. In 20 females, surgical excision of BIRADS 4 lesion was performed
because of the presence of LN in specimens from the vacuum-assisted or core-needle percutaneous biopsy.
Postoperative pathologic findings were compared to the radiological symptoms. In 13 women, LN did not produce
any radiological symptoms and was an additional histologic finding existing near the other lesion: fibroadenoma and
radial scar. In none of these lesions was an invasive cancer noticed. In one single patient, ductal carcinoma in situ was
observed in the other segment of the breast. Invasive ductal cancer developed in the contralateral breast in one patient.
In 11 patients, LN was diagnosed due to radiological symptoms produced by itself. In this group, the invasive lobular
cancer was found in seven lesions (64%). Our finding suggests that LN producing suspicious radiological symptoms
can be a different biologic type of this lesion when compared asymptomatic LN diagnosed which is usually found on
biopsy as additional microscopic pathology. Symptomatic LN is probably associated with a higher potential of malignant
transformation. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 417–424)
Keywords
breast cancer; breast biopsy; lobular carcinoma in situ; atypical lobular hyperplasia; lobular neoplasia
Title
Lobular neoplasia found on breast biopsy: marker of increased risk of malignancy or direct pre-cancerous lesion?
Journal
Folia Histochemica et Cytobiologica
Issue
Vol 49, No 3 (2011)
Article type
Original paper
Pages
417-424
Published online
2011-10-28
Page views
1873
Article views/downloads
1760
DOI
10.5603/FHC.2011.0059
Bibliographic record
Folia Histochem Cytobiol 2011;49(3):417-424.
Keywords
breast cancer
breast biopsy
lobular carcinoma in situ
atypical lobular hyperplasia
lobular neoplasia
Authors
Bartłomiej Szynglarewicz
Rafał Matkowski
Agnieszka Hałoń
Piotr Kasprzak
Józef Forgacz
Iwona Gisterek
Jan Kornafel