Processes of apoptosis and cell proliferation in uterine myomas originating from reproductive and perimenopausal women

Andrzej Plewka, Danuta Plewka, Paweł Madej, Grażyna Nowaczyk, Karolina Sieron-Stoltny, Beata Jakubiec-Bartnik
DOI: 10.5603/FHC.2011.0056
Folia Histochem Cytobiol 2011;49(3):398-404.

open access

Vol 49, No 3 (2011)
Original Papers
Published online: 2011-10-28
Submitted: 2012-01-05


We studied uterine myomas originating from females of reproductive age and from females of perimenopausal age. Uterine myomas represent benign tumors of the myometrium, and they develop frequently in women of reproductive age. The frequency of uterine myomas increases with age until women reach the menopause. The study included patients with a myomatous uterus, in the reproductive age or peri-menopausal age, independently evaluating small and large myomas. Myometrial alterations in their direct vicinity were evaluated independently of the myomas. The study included evaluation of immunolocalization of two index proteins which participate in myoma cells growth control: Ki-67 nuclear antigen and caspase 3. In women of reproductive age, both in small and large myomas, elevated immunostaining of Ki-67 was noted in parallel to low levels of caspase 3 staining, which indicated the ongoing process of proliferation. In women of peri-menopausal age with small or large myomas, no Ki-67 immunostaining was detected, while staining of caspase 3 manifested low levels. Proliferation in reproductive age women myomas is higher than in the peri-menopausal age. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 398–404)


apoptosis; cell proliferation; uterine myomas; Ki-67; caspase 3

About this article

Processes of apoptosis and cell proliferation in uterine myomas originating from reproductive and perimenopausal women


Folia Histochemica et Cytobiologica


Vol 49, No 3 (2011)



Published online




Bibliographic record

Folia Histochem Cytobiol 2011;49(3):398-404.


cell proliferation
uterine myomas
caspase 3


Andrzej Plewka
Danuta Plewka
Paweł Madej
Grażyna Nowaczyk
Karolina Sieron-Stoltny
Beata Jakubiec-Bartnik

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