Processes of apoptosis and cell proliferation in uterine myomas originating from reproductive and perimenopausal women

Andrzej Plewka, Danuta Plewka, Paweł Madej, Grażyna Nowaczyk, Karolina Sieron-Stoltny, Beata Jakubiec-Bartnik
DOI: 10.5603/FHC.2011.0056
·
Folia Histochem Cytobiol 2011;49(3):398-404.

open access

Vol 49, No 3 (2011)
Original Papers
Published online: 2011-10-28
Submitted: 2012-01-05

Abstract

We studied uterine myomas originating from females of reproductive age and from females of perimenopausal age. Uterine myomas represent benign tumors of the myometrium, and they develop frequently in women of reproductive age. The frequency of uterine myomas increases with age until women reach the menopause. The study included patients with a myomatous uterus, in the reproductive age or peri-menopausal age, independently evaluating small and large myomas. Myometrial alterations in their direct vicinity were evaluated independently of the myomas. The study included evaluation of immunolocalization of two index proteins which participate in myoma cells growth control: Ki-67 nuclear antigen and caspase 3. In women of reproductive age, both in small and large myomas, elevated immunostaining of Ki-67 was noted in parallel to low levels of caspase 3 staining, which indicated the ongoing process of proliferation. In women of peri-menopausal age with small or large myomas, no Ki-67 immunostaining was detected, while staining of caspase 3 manifested low levels. Proliferation in reproductive age women myomas is higher than in the peri-menopausal age. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 398–404)

Keywords

apoptosis; cell proliferation; uterine myomas; Ki-67; caspase 3

About this article
Title

Processes of apoptosis and cell proliferation in uterine myomas originating from reproductive and perimenopausal women

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 49, No 3 (2011)

Pages

398-404

Published online

2011-10-28

DOI

10.5603/FHC.2011.0056

Bibliographic record

Folia Histochem Cytobiol 2011;49(3):398-404.

Keywords

apoptosis
cell proliferation
uterine myomas
Ki-67
caspase 3

Authors

Andrzej Plewka
Danuta Plewka
Paweł Madej
Grażyna Nowaczyk
Karolina Sieron-Stoltny
Beata Jakubiec-Bartnik

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl