open access

Vol 49, No 3 (2011)
Review paper
Submitted: 2012-01-05
Published online: 2011-10-28
Get Citation

CD163 and its role in inflammation

Krzysztof Kowal, Richard Silver, Emila Sławińska, Marek Bielecki, Lech Chyczewski, Otylia Kowal-Bielecka
DOI: 10.5603/FHC.2011.0052
·
Folia Histochem Cytobiol 2011;49(3):365-374.

open access

Vol 49, No 3 (2011)
REVIEW
Submitted: 2012-01-05
Published online: 2011-10-28

Abstract

Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopulations exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential. The expression of CD163 is strongly induced by anti-inflammatory mediators such as glucocorticoids and interleukin-10, while being inhibited by pro-inflammatory mediators such as interferon-gamma. CD163-expressing mononuclear phagocytes, as well as soluble CD163, may both take part in downregulating an inflammatory response. It seems, therefore, that CD163 may be an interesting target for therapeutic modulation of the inflammatory response. (Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 3, 365–374)

Abstract

Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopulations exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential. The expression of CD163 is strongly induced by anti-inflammatory mediators such as glucocorticoids and interleukin-10, while being inhibited by pro-inflammatory mediators such as interferon-gamma. CD163-expressing mononuclear phagocytes, as well as soluble CD163, may both take part in downregulating an inflammatory response. It seems, therefore, that CD163 may be an interesting target for therapeutic modulation of the inflammatory response. (Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 3, 365–374)
Get Citation

Keywords

CD163; inflammation

About this article
Title

CD163 and its role in inflammation

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 49, No 3 (2011)

Article type

Review paper

Pages

365-374

Published online

2011-10-28

DOI

10.5603/FHC.2011.0052

Bibliographic record

Folia Histochem Cytobiol 2011;49(3):365-374.

Keywords

CD163
inflammation

Authors

Krzysztof Kowal
Richard Silver
Emila Sławińska
Marek Bielecki
Lech Chyczewski
Otylia Kowal-Bielecka

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl