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MPP1-based mechanism of resting state raft organization in the plasma membrane. Is it a general or specialized mechanism in erythroid cells?
Affiliations- Department of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw
open access
Abstract
Biological membranes are organized in various microdomains, one of the best known being called membrane rafts. The major function of these is thought to organize signaling partners into functional complexes. An important protein found in membrane raft microdomains of erythroid and other blood cells is MPP1 (membrane palmitoylated protein 1)/p55. MPP1 (p55) belongs to the MAGUK (membrane-associated guanylate kinase homolog) family and it is a major target of palmitoylation in the red blood cells (RBCs) membrane. The well-known function of this protein is to participate in formation of the junctional complex of the erythrocyte membrane skeleton. However, its function as a “raft organizer” is not well understood. In this review we focus on recent reports concerning MPP1 participation in membrane rafts organization in erythroid cells, including its role in signal transduction. Currently it is not known whether MPP1 could have a similar role in cell types other than erythroid lineage. We present also preliminary data regarding the expression level of MPP1 gene in several non-erythroid cell lines.
Abstract
Biological membranes are organized in various microdomains, one of the best known being called membrane rafts. The major function of these is thought to organize signaling partners into functional complexes. An important protein found in membrane raft microdomains of erythroid and other blood cells is MPP1 (membrane palmitoylated protein 1)/p55. MPP1 (p55) belongs to the MAGUK (membrane-associated guanylate kinase homolog) family and it is a major target of palmitoylation in the red blood cells (RBCs) membrane. The well-known function of this protein is to participate in formation of the junctional complex of the erythrocyte membrane skeleton. However, its function as a “raft organizer” is not well understood. In this review we focus on recent reports concerning MPP1 participation in membrane rafts organization in erythroid cells, including its role in signal transduction. Currently it is not known whether MPP1 could have a similar role in cell types other than erythroid lineage. We present also preliminary data regarding the expression level of MPP1 gene in several non-erythroid cell lines.
Keywords
membrane palmitoylated protein 1 (MPP1); resting state rafts; lateral membrane organization; raft-associated proteins
About this articleTitle
MPP1-based mechanism of resting state raft organization in the plasma membrane. Is it a general or specialized mechanism in erythroid cells?
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Review paper
Pages
43-55
Published online
2019-05-16
Page views
2505
Article views/downloads
1155
DOI
Pubmed
Bibliographic record
Folia Histochem Cytobiol 2019;57(2):43-55.
Keywords
membrane palmitoylated protein 1 (MPP1)
resting state rafts
lateral membrane organization
raft-associated proteins
Authors
Magdalena Trybus
Lukasz Niemiec
Agnieszka Biernatowska
Anita Hryniewicz-Jankowska
Aleksander F. Sikorski
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