Vol 56, No 1 (2018)
Review paper
Published online: 2018-03-02
Cancer immunotherapy in mice and humans: personal observations
Abstract
An experiment involving active immunotherapy of leukemia in mice and its extension to human patients with
chronic lymphocytic leukemia is described. First, anticancer activation of the immune system, how it is achieved,
and observations of the central blockade of the immune system in leukemia are discussed. Clinical results of
antileukemia immune activation are then presented, along with a description of new attempts to remove the
immune checkpoint blockade. Personal observations are presented on possible further steps to achieving more
effective active immunotherapy of cancer.
Keywords: apoptosisL1210 leukemia cellsDBA/2 micethymushuman B-CLLvaccination with apoptotic CLL lymphocytesclinical trial
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