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Vol 56, No 1 (2018)
Review paper
Submitted: 2018-02-16
Accepted: 2018-02-16
Published online: 2018-03-02
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Cancer immunotherapy in mice and humans: personal observations

Jerzy Kawiak1
DOI: 10.5603/FHC.a2018.0002
·
Pubmed: 29504116
·
Folia Histochem Cytobiol 2018;56(1):1-10.
Affiliations
  1. Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland, ul. Ksiecia Trojdena 4, 02-109 Warsaw, Poland

open access

Vol 56, No 1 (2018)
REVIEW
Submitted: 2018-02-16
Accepted: 2018-02-16
Published online: 2018-03-02

Abstract

An experiment involving active immunotherapy of leukemia in mice and its extension to human patients with
chronic lymphocytic leukemia is described. First, anticancer activation of the immune system, how it is achieved,
and observations of the central blockade of the immune system in leukemia are discussed. Clinical results of
antileukemia immune activation are then presented, along with a description of new attempts to remove the
immune checkpoint blockade. Personal observations are presented on possible further steps to achieving more
effective active immunotherapy of cancer.

Abstract

An experiment involving active immunotherapy of leukemia in mice and its extension to human patients with
chronic lymphocytic leukemia is described. First, anticancer activation of the immune system, how it is achieved,
and observations of the central blockade of the immune system in leukemia are discussed. Clinical results of
antileukemia immune activation are then presented, along with a description of new attempts to remove the
immune checkpoint blockade. Personal observations are presented on possible further steps to achieving more
effective active immunotherapy of cancer.

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Keywords

apoptosis; L1210 leukemia cells; DBA/2 mice; thymus; human B-CLL; vaccination with apoptotic CLL lymphocytes; clinical trial

About this article
Title

Cancer immunotherapy in mice and humans: personal observations

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 56, No 1 (2018)

Article type

Review paper

Pages

1-10

Published online

2018-03-02

Page views

3018

Article views/downloads

1492

DOI

10.5603/FHC.a2018.0002

Pubmed

29504116

Bibliographic record

Folia Histochem Cytobiol 2018;56(1):1-10.

Keywords

apoptosis
L1210 leukemia cells
DBA/2 mice
thymus
human B-CLL
vaccination with apoptotic CLL lymphocytes
clinical trial

Authors

Jerzy Kawiak

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