open access

Vol 56, No 2 (2018)
Original paper
Submitted: 2017-12-14
Accepted: 2018-06-02
Published online: 2018-06-07
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Immunohistochemical expression of Fascin-1 in colorectal cancer in relation to clinical and pathological parameters

Barbara M. Piskor1, Anna Pryczynicz2, Emilia Lubowicka1, Katarzyna Miniewska3, Justyna Zinczuk2, Konrad Zareba4, Katarzyna Guzinska-Ustymowicz2
·
Pubmed: 29888780
·
Folia Histochem Cytobiol 2018;56(2):106-112.
Affiliations
  1. Department of Esthetic Medicine, Medical University of Bialystok, Bialystok, Poland
  2. Department of General Pathomorphology, Medical University of Bialystok, Bialystok, Poland
  3. Clinical Research Center, Medical University of Bialystok, Bialystok, Poland
  4. 2nd Department of General and Gastroenterological Surgery, Medical University of Bialystok, Bialystok, Poland

open access

Vol 56, No 2 (2018)
ORIGINAL PAPERS
Submitted: 2017-12-14
Accepted: 2018-06-02
Published online: 2018-06-07

Abstract

   Introduction. Fascins are a group of proteins taking part in the maintenance of a proper structure of the cellular cytoskeleton. Fascin-1 is an actin-bundling protein present in neurons, fibroblasts, endothelial, smooth muscle, dendritic and mesenchymal cells whereas lack of its expression is characteristic of epithelial cells. Fascin-1 overexpression can be observed in neoplastic cells. Therefore, the aim of this study was to assess the expression of Fascin-1 protein in patients with colorectal cancer (CRC) and to analyze associations between Fascin-1 ex­pression and clinical-pathological parameters. Material and methods. The study material included postoperative samples (tumor and unchanged colon tissue) ob­tained from 51 CRC patients. Fascin-1 expression was assessed in the paraffin sections by immunohistochemistry. Results. A statistically significant correlation was found between the histological type of cancer and the expres­sion of Fascin-1 (p = 0.012). Increased expression of Fascin-1 in CRC was more frequent in adenocarcinoma type without the mucosal component with a better prognosis and decreased expression of this protein correlated with infiltration of cancer cells to blood and lymphatic vessels (p = 0.038). Conclusions. Our findings indicate a potential role of Fascin-1 in the pathogenesis of colon cancer; however, further studies will show whether this protein plays a role in the infiltration of colorectal cancer cells.

Abstract

   Introduction. Fascins are a group of proteins taking part in the maintenance of a proper structure of the cellular cytoskeleton. Fascin-1 is an actin-bundling protein present in neurons, fibroblasts, endothelial, smooth muscle, dendritic and mesenchymal cells whereas lack of its expression is characteristic of epithelial cells. Fascin-1 overexpression can be observed in neoplastic cells. Therefore, the aim of this study was to assess the expression of Fascin-1 protein in patients with colorectal cancer (CRC) and to analyze associations between Fascin-1 ex­pression and clinical-pathological parameters. Material and methods. The study material included postoperative samples (tumor and unchanged colon tissue) ob­tained from 51 CRC patients. Fascin-1 expression was assessed in the paraffin sections by immunohistochemistry. Results. A statistically significant correlation was found between the histological type of cancer and the expres­sion of Fascin-1 (p = 0.012). Increased expression of Fascin-1 in CRC was more frequent in adenocarcinoma type without the mucosal component with a better prognosis and decreased expression of this protein correlated with infiltration of cancer cells to blood and lymphatic vessels (p = 0.038). Conclusions. Our findings indicate a potential role of Fascin-1 in the pathogenesis of colon cancer; however, further studies will show whether this protein plays a role in the infiltration of colorectal cancer cells.

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Keywords

colorectal cancer; Fascin-1; metastasis; IHC

About this article
Title

Immunohistochemical expression of Fascin-1 in colorectal cancer in relation to clinical and pathological parameters

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 56, No 2 (2018)

Article type

Original paper

Pages

106-112

Published online

2018-06-07

Page views

2300

Article views/downloads

1537

DOI

10.5603/FHC.a2018.0011

Pubmed

29888780

Bibliographic record

Folia Histochem Cytobiol 2018;56(2):106-112.

Keywords

colorectal cancer
Fascin-1
metastasis
IHC

Authors

Barbara M. Piskor
Anna Pryczynicz
Emilia Lubowicka
Katarzyna Miniewska
Justyna Zinczuk
Konrad Zareba
Katarzyna Guzinska-Ustymowicz

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