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Vol 56, No 2 (2018)
Review paper
Submitted: 2017-03-26
Accepted: 2018-05-29
Published online: 2018-06-12
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Endometriosis — insights into a multifaceted entity

Cornelia Amalinei1, Ioana Păvăleanu1, Ludmila Lozneanu1, Raluca Balan1, Simona-Eliza Giuşcă2, Irina-Draga Căruntu1
DOI: 10.5603/FHC.a2018.0013
·
Folia Histochem Cytobiol 2018;56(2):61-82.
Affiliations
  1. Department of Morphofunctional Sciences I — Histology, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania
  2. Department of Morphofunctional Sciences I — Pathology, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania

open access

Vol 56, No 2 (2018)
REVIEW
Submitted: 2017-03-26
Accepted: 2018-05-29
Published online: 2018-06-12

Abstract

 Firstly described at the end of nineteenth century, endometriosis remains an enigmatic disease, from etio­pathogenesis to specific markers of diagnosis and its ability to associate with malignancies. Our review has been designed from a historical perspective and steps up to an updated understanding of the disease, facilitated by relatively recent molecular and genetic progresses. Although the histopathological diagnosis is relatively simple, the therapy is difficult or ineffective. Experimental models have been extremely useful as they reproduce the human disease and allow the testing of different potential modulators or treatment options. Due to molecular resemblance to carcinogenesis, applications of anti-cancer agents are currently under scrutiny. The desired goal of an efficient therapy against symptomatic disease, along with associated infertility and malignancies, needs a deeper insight into the complex mechanisms involved in endometriosis initiation, development, and progres­sion. Current trends in genomic and proteomic approaches are useful for a more accurate classification and for the identification of new therapeutic targets.

Abstract

 Firstly described at the end of nineteenth century, endometriosis remains an enigmatic disease, from etio­pathogenesis to specific markers of diagnosis and its ability to associate with malignancies. Our review has been designed from a historical perspective and steps up to an updated understanding of the disease, facilitated by relatively recent molecular and genetic progresses. Although the histopathological diagnosis is relatively simple, the therapy is difficult or ineffective. Experimental models have been extremely useful as they reproduce the human disease and allow the testing of different potential modulators or treatment options. Due to molecular resemblance to carcinogenesis, applications of anti-cancer agents are currently under scrutiny. The desired goal of an efficient therapy against symptomatic disease, along with associated infertility and malignancies, needs a deeper insight into the complex mechanisms involved in endometriosis initiation, development, and progres­sion. Current trends in genomic and proteomic approaches are useful for a more accurate classification and for the identification of new therapeutic targets.

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Keywords

endometriosis; retrograde menstruation; cytokines; angiogenesis; apoptosis; precursor lesion; carcinogenesis; anti-cancer agents

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Title

Endometriosis — insights into a multifaceted entity

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 56, No 2 (2018)

Article type

Review paper

Pages

61-82

Published online

2018-06-12

Page views

3640

Article views/downloads

3075

DOI

10.5603/FHC.a2018.0013

Bibliographic record

Folia Histochem Cytobiol 2018;56(2):61-82.

Keywords

endometriosis
retrograde menstruation
cytokines
angiogenesis
apoptosis
precursor lesion
carcinogenesis
anti-cancer agents

Authors

Cornelia Amalinei
Ioana Păvăleanu
Ludmila Lozneanu
Raluca Balan
Simona-Eliza Giuşcă
Irina-Draga Căruntu

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