open access

Vol 55, No 1 (2017)
Original paper
Submitted: 2016-08-19
Accepted: 2017-03-17
Published online: 2017-03-23
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Decreased expression of survivin 2B in human pituitary adenomas. A preliminary study

Joanna Waligorska-Stachura, Nadia Sawicka-Gutaj, Maciej Zabel, Wlodzimierz Liebert, Pawel Gut, Agata Czarnywojtek, Marek Ruchala
DOI: 10.5603/FHC.a2017.0002
·
Pubmed: 28509313
·
Folia Histochem Cytobiol 2017;55(1):21-25.

open access

Vol 55, No 1 (2017)
ORIGINAL PAPERS
Submitted: 2016-08-19
Accepted: 2017-03-17
Published online: 2017-03-23

Abstract

Introduction. We aimed to investigate survivin and its splice variants DEx3 and 2B expressions in pituitary adenomas and normal pituitary glands using immunohistochemistry.

Material and methods. The study group consisted of eight pituitary adenomas: five of non-functional tumors, two of GH-secreting tumors, and one PRL-secreting tumor. Eight healthy pituitary tissue samples obtained after autopsy served as controls.

Results. Survivin expression was found in 87.5% of the study group and 100% of the controls. A positive staining of survivin 2B was found in 62.5% of pituitary adenomas and 100% of controls. Survivin DEx3 was recognized in 25% of pituitary adenomas and 12.5% of normal pituitary glands. There was significantly lower immunoreactivity of survivin 2B in pituitary adenomas when compared with normal pituitary glands (p = 0.0498).

Conclusions: Survivin and its splice variants might be involved to some extent in benign tumor growth of pituitary adenomas. However, survivin cannot be regarded as a candidate for targeted therapy or molecular biomarker of pituitary adenomas.

Abstract

Introduction. We aimed to investigate survivin and its splice variants DEx3 and 2B expressions in pituitary adenomas and normal pituitary glands using immunohistochemistry.

Material and methods. The study group consisted of eight pituitary adenomas: five of non-functional tumors, two of GH-secreting tumors, and one PRL-secreting tumor. Eight healthy pituitary tissue samples obtained after autopsy served as controls.

Results. Survivin expression was found in 87.5% of the study group and 100% of the controls. A positive staining of survivin 2B was found in 62.5% of pituitary adenomas and 100% of controls. Survivin DEx3 was recognized in 25% of pituitary adenomas and 12.5% of normal pituitary glands. There was significantly lower immunoreactivity of survivin 2B in pituitary adenomas when compared with normal pituitary glands (p = 0.0498).

Conclusions: Survivin and its splice variants might be involved to some extent in benign tumor growth of pituitary adenomas. However, survivin cannot be regarded as a candidate for targeted therapy or molecular biomarker of pituitary adenomas.

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Keywords

pituitary adenoma; surviving; survivin DEx3; survivin 2B; IHC

About this article
Title

Decreased expression of survivin 2B in human pituitary adenomas. A preliminary study

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 55, No 1 (2017)

Article type

Original paper

Pages

21-25

Published online

2017-03-23

DOI

10.5603/FHC.a2017.0002

Pubmed

28509313

Bibliographic record

Folia Histochem Cytobiol 2017;55(1):21-25.

Keywords

pituitary adenoma
surviving
survivin DEx3
survivin 2B
IHC

Authors

Joanna Waligorska-Stachura
Nadia Sawicka-Gutaj
Maciej Zabel
Wlodzimierz Liebert
Pawel Gut
Agata Czarnywojtek
Marek Ruchala

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