open access

Vol 54, No 3 (2016)
Review paper
Submitted: 2016-06-11
Accepted: 2016-07-27
Published online: 2016-08-16
Get Citation

Pericardium: structure and function in health and disease

Maria Jaworska-Wilczynska, Pawel Trzaskoma, Andrzej A. Szczepankiewicz, Tomasz Hryniewiecki
DOI: 10.5603/FHC.a2016.0014
·
Pubmed: 27654013
·
Folia Histochem Cytobiol 2016;54(3):121-125.

open access

Vol 54, No 3 (2016)
REVIEW
Submitted: 2016-06-11
Accepted: 2016-07-27
Published online: 2016-08-16

Abstract

Normal pericardium consists of an outer sac called fibrous pericardium and an inner one called serous pericardium. The two layers of serous pericardium: visceral and parietal are separated by the pericardial cavity, which contains 20 to 60 mL of the plasma ultrafiltrate.

The pericardium acts as mechanical protection for the heart and big vessels, and a lubrication to reduce friction between the heart and the surrounding structures.

A very important role in all aspects of pericardial functions is played by mesothelial cells. The mesothelial cells form a monolayer lining the serosal cavity and play an important role in antigen presentation, inflammation and tissue repair, coagulation and fibrinolysis. The two major types of mesothelial cells, flat or cuboid, differ substantially in their ultrastructure and, probably, functions. The latter display abundant microvilli, RER, Golgi dense bodies, membrane-bound vesicles and intracellular vacuoles containing electron-dense material described as dense bodies. The normal structure and functions of the pericardium determine correct healing after its injury as a result of surgery or microbial infection. The unfavorable resolution of acute or chronic pericarditis leads to the formation of adhesions between pericardial leaflets which may lead to serious complications.

Abstract

Normal pericardium consists of an outer sac called fibrous pericardium and an inner one called serous pericardium. The two layers of serous pericardium: visceral and parietal are separated by the pericardial cavity, which contains 20 to 60 mL of the plasma ultrafiltrate.

The pericardium acts as mechanical protection for the heart and big vessels, and a lubrication to reduce friction between the heart and the surrounding structures.

A very important role in all aspects of pericardial functions is played by mesothelial cells. The mesothelial cells form a monolayer lining the serosal cavity and play an important role in antigen presentation, inflammation and tissue repair, coagulation and fibrinolysis. The two major types of mesothelial cells, flat or cuboid, differ substantially in their ultrastructure and, probably, functions. The latter display abundant microvilli, RER, Golgi dense bodies, membrane-bound vesicles and intracellular vacuoles containing electron-dense material described as dense bodies. The normal structure and functions of the pericardium determine correct healing after its injury as a result of surgery or microbial infection. The unfavorable resolution of acute or chronic pericarditis leads to the formation of adhesions between pericardial leaflets which may lead to serious complications.

Get Citation

Keywords

pericardium; mesothelial cells; ultrastructure; 3D; SBF-SEM; pericarditis; leaflets adhesions; tissue repair

About this article
Title

Pericardium: structure and function in health and disease

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 54, No 3 (2016)

Article type

Review paper

Pages

121-125

Published online

2016-08-16

DOI

10.5603/FHC.a2016.0014

Pubmed

27654013

Bibliographic record

Folia Histochem Cytobiol 2016;54(3):121-125.

Keywords

pericardium
mesothelial cells
ultrastructure
3D
SBF-SEM
pericarditis
leaflets adhesions
tissue repair

Authors

Maria Jaworska-Wilczynska
Pawel Trzaskoma
Andrzej A. Szczepankiewicz
Tomasz Hryniewiecki

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl