Vol 45, No 1 (2007)
Original paper
Submitted: 2011-12-19
Published online: 2007-03-24
Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation.
Anna Pryczynicz, Katarzyna Guzińska-Ustymowicz, Violetta Dymicka-Piekarska, Jolanta Czyzewska, Andrzej Kemona
Folia Histochem Cytobiol 2007;45(1):37-40.
Vol 45, No 1 (2007)
ORIGINAL PAPERS
Submitted: 2011-12-19
Published online: 2007-03-24
Abstract
The objective of the current study was to assess the expression of matrix metalloproteinase 9 (MMP-9) in pancreatic ductal carcinoma and to examine its correlation with chosen clinico-anatomical parameters. The study group consisted of 36 patients with pancreatic ductal carcinoma. Tumors were stained using immunohistochemical method (NCL -MMP-9, Novocastra). No correlation was found between tumor MMP-9 expression and age, gender or grade of histological malignancy. However, statistical analysis revealed a relationship between tumor MMP-9 expression and histological type (adenocarcinoma mucinosum) of pancreatic carcinoma. The expression was strongly correlated with lymph node involvement and occurrence of distant metastases (p<0.00001). The results indicate a correlation between the expression of MMP-9 in pancreatic ductal carcinoma and worse prognosis (shown by lymph node involvement and distant metastases).
Abstract
The objective of the current study was to assess the expression of matrix metalloproteinase 9 (MMP-9) in pancreatic ductal carcinoma and to examine its correlation with chosen clinico-anatomical parameters. The study group consisted of 36 patients with pancreatic ductal carcinoma. Tumors were stained using immunohistochemical method (NCL -MMP-9, Novocastra). No correlation was found between tumor MMP-9 expression and age, gender or grade of histological malignancy. However, statistical analysis revealed a relationship between tumor MMP-9 expression and histological type (adenocarcinoma mucinosum) of pancreatic carcinoma. The expression was strongly correlated with lymph node involvement and occurrence of distant metastases (p<0.00001). The results indicate a correlation between the expression of MMP-9 in pancreatic ductal carcinoma and worse prognosis (shown by lymph node involvement and distant metastases).
Title
Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation.
Journal
Folia Histochemica et Cytobiologica
Issue
Vol 45, No 1 (2007)
Article type
Original paper
Pages
37-40
Published online
2007-03-24
Page views
1468
Article views/downloads
1218
Bibliographic record
Folia Histochem Cytobiol 2007;45(1):37-40.
Authors
Anna Pryczynicz
Katarzyna Guzińska-Ustymowicz
Violetta Dymicka-Piekarska
Jolanta Czyzewska
Andrzej Kemona