open access

Vol 54, No 3 (2016)
Original paper
Submitted: 2016-03-16
Accepted: 2016-08-02
Published online: 2016-08-16
Get Citation

Lymphangioinvasion in routine H&E staining is strongly associated with poor clinical outcome in lymph node-negative cutaneous melanoma patients

Piotr Donizy, Maciej Kaczorowski, Agnieszka Halon, Marek Leskiewicz, Rafal Matkowski
DOI: 10.5603/FHC.a2016.0016
·
Pubmed: 27654015
·
Folia Histochem Cytobiol 2016;54(3):126-133.

open access

Vol 54, No 3 (2016)
ORIGINAL PAPERS
Submitted: 2016-03-16
Accepted: 2016-08-02
Published online: 2016-08-16

Abstract

Introduction. Lymphatic invasion (LYI) and lymphangiogenesis in the primary tumor are important processes related to the dissemination of neoplasms. The aim of the study was to examine the relationship of LYI status in cutaneous melanoma with patient survival and clinicopathological data.

Material and methods. LYI status was assessed in 104 hematoxylin-eosin (H&E) stained melanoma primary tumor samples and analyzed in relation to patient survival and other clinicopathological and histopathological characteristics.

Results. LYI was found in 30 (28.8%) patients. It was observed more frequently in ulcerated, proliferating, and thicker tumors. It correlated with the presence of sentinel lymph node, regional and distant metastases. The presence of LYI significantly correlated with shorter overall survival, cancer specific overall survival and disease-free survival in Kaplan-Meier analysis (all P < 0.001). Positive LYI status was a factor of unfavorable prognosis also in patients without regional lymph node metastases.

Conclusions. Our results support earlier observations that LYI is a powerful prognostic factor. We recommend an assessment of LYI status during routine review of cutaneous melanoma slides stained with H&E as a standard, potentially informative, yet economically beneficial procedure.  

Abstract

Introduction. Lymphatic invasion (LYI) and lymphangiogenesis in the primary tumor are important processes related to the dissemination of neoplasms. The aim of the study was to examine the relationship of LYI status in cutaneous melanoma with patient survival and clinicopathological data.

Material and methods. LYI status was assessed in 104 hematoxylin-eosin (H&E) stained melanoma primary tumor samples and analyzed in relation to patient survival and other clinicopathological and histopathological characteristics.

Results. LYI was found in 30 (28.8%) patients. It was observed more frequently in ulcerated, proliferating, and thicker tumors. It correlated with the presence of sentinel lymph node, regional and distant metastases. The presence of LYI significantly correlated with shorter overall survival, cancer specific overall survival and disease-free survival in Kaplan-Meier analysis (all P < 0.001). Positive LYI status was a factor of unfavorable prognosis also in patients without regional lymph node metastases.

Conclusions. Our results support earlier observations that LYI is a powerful prognostic factor. We recommend an assessment of LYI status during routine review of cutaneous melanoma slides stained with H&E as a standard, potentially informative, yet economically beneficial procedure.  

Get Citation

Keywords

lymphatic invasion; prognosis; disease-free survival; malignant melanoma

About this article
Title

Lymphangioinvasion in routine H&E staining is strongly associated with poor clinical outcome in lymph node-negative cutaneous melanoma patients

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 54, No 3 (2016)

Article type

Original paper

Pages

126-133

Published online

2016-08-16

DOI

10.5603/FHC.a2016.0016

Pubmed

27654015

Bibliographic record

Folia Histochem Cytobiol 2016;54(3):126-133.

Keywords

lymphatic invasion
prognosis
disease-free survival
malignant melanoma

Authors

Piotr Donizy
Maciej Kaczorowski
Agnieszka Halon
Marek Leskiewicz
Rafal Matkowski

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl