Vol 49, No 1 (2011)
Original paper
Published online: 2011-04-19
The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma
DOI: 10.5603/FHC.2011.0005
Folia Histochem Cytobiol 2011;49(1):26-33.
Abstract
To investigate the prognostic significance of Survivin and Nectin-4 expression in breast carcinomas.
Imprint smears were obtained from 140 breast carcinoma specimens and studied immunocytochemically for the
expression of Survivin and Nectin-4. The results were correlated with several clinicopathological parameters,
including five-year survival. Increased Survivin staining pattern correlated with increased grade (p < 0.0001),
increased lymph node invasion (p < 0.0001), increased tumor size and reduced survival (p < 0.0001). Elevated
Nectin-4 expression also correlated significantly with increased grade (p < 0.0001), increased tumor size
(p < 0.0001) and reduced survival (p < 0.0001). In addition, Survivin and Nectin-4 staining patterns correlated
strongly with one another (p < 0.0001). However, on multivariate analysis, neither Survivin nor Nectin-4 expression
seemed to have an independent impact on survival in our study cases. The findings of our study suggest that
increased expression of Survivin and Nectin-4 may indicate a worse prognosis in breast cancer patients. The
exact implications of the expression of these markers in breast cancer prognosis and treatment remain to be
clarified. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 26–33)
Keywords: breast cancerSurvivinNectin-4immunocytochemistryprognosis
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