The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma

Anna Maria Athanassiadou; Efstratios Patsouris; Angelos Tsipis; Maria Gonidi; Pauline Athanassiadou

doi:10.5603/FHC.2011.0005

Vol 49, No 1 (2011)

Original paper

Published online: 2011-04-19

Submitted: 2011-12-19

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The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma

Anna Maria Athanassiadou, Efstratios Patsouris, Angelos Tsipis, Maria Gonidi, Pauline Athanassiadou

DOI: 10.5603/FHC.2011.0005

Folia Histochem Cytobiol 2011;49(1):26-33.

Vol 49, No 1 (2011)

ORIGINAL PAPERS

Published online: 2011-04-19

Submitted: 2011-12-19

Abstract

To investigate the prognostic significance of Survivin and Nectin-4 expression in breast carcinomas. Imprint smears were obtained from 140 breast carcinoma specimens and studied immunocytochemically for the expression of Survivin and Nectin-4. The results were correlated with several clinicopathological parameters, including five-year survival. Increased Survivin staining pattern correlated with increased grade (p < 0.0001), increased lymph node invasion (p < 0.0001), increased tumor size and reduced survival (p < 0.0001). Elevated Nectin-4 expression also correlated significantly with increased grade (p < 0.0001), increased tumor size (p < 0.0001) and reduced survival (p < 0.0001). In addition, Survivin and Nectin-4 staining patterns correlated strongly with one another (p < 0.0001). However, on multivariate analysis, neither Survivin nor Nectin-4 expression seemed to have an independent impact on survival in our study cases. The findings of our study suggest that increased expression of Survivin and Nectin-4 may indicate a worse prognosis in breast cancer patients. The exact implications of the expression of these markers in breast cancer prognosis and treatment remain to be clarified. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 26–33)

Abstract

To investigate the prognostic significance of Survivin and Nectin-4 expression in breast carcinomas. Imprint smears were obtained from 140 breast carcinoma specimens and studied immunocytochemically for the expression of Survivin and Nectin-4. The results were correlated with several clinicopathological parameters, including five-year survival. Increased Survivin staining pattern correlated with increased grade (p < 0.0001), increased lymph node invasion (p < 0.0001), increased tumor size and reduced survival (p < 0.0001). Elevated Nectin-4 expression also correlated significantly with increased grade (p < 0.0001), increased tumor size (p < 0.0001) and reduced survival (p < 0.0001). In addition, Survivin and Nectin-4 staining patterns correlated strongly with one another (p < 0.0001). However, on multivariate analysis, neither Survivin nor Nectin-4 expression seemed to have an independent impact on survival in our study cases. The findings of our study suggest that increased expression of Survivin and Nectin-4 may indicate a worse prognosis in breast cancer patients. The exact implications of the expression of these markers in breast cancer prognosis and treatment remain to be clarified. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 26–33)

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Keywords

breast cancer; Survivin; Nectin-4; immunocytochemistry; prognosis

About this article

Title

The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 49, No 1 (2011)

Article type

Original paper

Pages

26-33

Published online

2011-04-19

DOI

10.5603/FHC.2011.0005

Bibliographic record

Folia Histochem Cytobiol 2011;49(1):26-33.

Keywords

breast cancer
Survivin
Nectin-4
immunocytochemistry
prognosis

Authors

Anna Maria Athanassiadou
Efstratios Patsouris
Angelos Tsipis
Maria Gonidi
Pauline Athanassiadou