Vol 49, No 2 (2011)
Original paper
Published online: 2011-07-11

open access

Page views 2399
Article views/downloads 2130
Get Citation

Connect on Social Media

Connect on Social Media

JAK2 mutation status, hemostatic risk factors and thrombophilic factors in essential thrombocythemia (ET) patients

Bożena Sokołowska, Aleksandra Nowaczyńska, Ksenia Bykowska, Sylwia Chocholska, Katarzyna Wejksza, Adam Walter-Croneck, Tomasz Gromek, Anna M. Kowalska, Martyna Kandefer-Szerszeń, Anna Dmoszyńska
DOI: 10.5603/FHC.2011.0037
Folia Histochem Cytobiol 2011;49(2):267-271.

Abstract

The recently discovered JAK2 V617F point mutation, found in 50–60% of ET patients, has been reported to be associated with a higher risk of thrombotic events. In this study, we explored if JAK2 V617F mutation, or coexisting thrombophilic and hemostatic risk factors, contributed to these complications. We examined 32 patients with ET, and looked for pathogenetic JAK2 V617F mutation and prothrombotic genes mutations: factor V Leiden, prothrombin and MTHFR. We also evaluated plasma levels of fibrinogen, factors VIII and XII, AT, protein C, protein S and serum level of homocysteine. Urokinase concentration was assessed in patients’ plasma as well as platelet lysates. There was no difference in the number of thrombotic complications between ET patients with and without JAK2 mutation. However, we found a number of thrombophilic and hemostatic risk factors that could contribute to thrombotic complications in ET patients. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 2, pp. 267–271)

Article available in PDF format

View PDF Download PDF file