open access

Vol 53, No 3 (2015)
Review paper
Submitted: 2015-02-02
Accepted: 2015-09-04
Published online: 2015-09-04
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Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Iwona Bogacka, Aleksandra Kurzynska, Marek Bogacki, Katarzyna Chojnowska
DOI: 10.5603/fhc.a2015.0023
·
Pubmed: 26339984
·
Folia Histochem Cytobiol 2015;53(3):189-200.

open access

Vol 53, No 3 (2015)
REVIEW
Submitted: 2015-02-02
Accepted: 2015-09-04
Published online: 2015-09-04

Abstract

Peroxisome proliferator-activated receptors (PPARs) belong to a ligand-dependent nuclear receptor family. In the past decade, numerous studies have revealed the presence and significance of PPARs in the reproductive system. PPARs are expressed at different levels of hypothalamic-pituitary-gonadal (HPG) axis. They are also present in the uterus as well as in the placenta and embryonic tissues of different species. PPARs significance has been reported during the estrous/menstrual cycle and pregnancy with the gamma isoform studied most frequently. Several studies indicate that PPARs regulate proliferation of ovarian cells, tissue remodeling and steroidogenesis. In the endometrium, PPARs are engaged in the regulation of prostaglandins, steroids and cytokines synthesis. The role of PPARs in the trophoblast differentiation, maturation and invasion as well as in the embryo development has also been demonstrated. In this review, we summarize current findings concerning the role of PPARs in the regulation of reproductive functions at different levels of the HPG axis during various physiological statuses of females. In addition, the role of PPARs in the modulation of uterine functions as well as the placenta and embryo development has also been discussed.

Abstract

Peroxisome proliferator-activated receptors (PPARs) belong to a ligand-dependent nuclear receptor family. In the past decade, numerous studies have revealed the presence and significance of PPARs in the reproductive system. PPARs are expressed at different levels of hypothalamic-pituitary-gonadal (HPG) axis. They are also present in the uterus as well as in the placenta and embryonic tissues of different species. PPARs significance has been reported during the estrous/menstrual cycle and pregnancy with the gamma isoform studied most frequently. Several studies indicate that PPARs regulate proliferation of ovarian cells, tissue remodeling and steroidogenesis. In the endometrium, PPARs are engaged in the regulation of prostaglandins, steroids and cytokines synthesis. The role of PPARs in the trophoblast differentiation, maturation and invasion as well as in the embryo development has also been demonstrated. In this review, we summarize current findings concerning the role of PPARs in the regulation of reproductive functions at different levels of the HPG axis during various physiological statuses of females. In addition, the role of PPARs in the modulation of uterine functions as well as the placenta and embryo development has also been discussed.

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Keywords

PPARs; ovary; uterus; placenta; reproduction; estrous cycle; pregnancy

About this article
Title

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 53, No 3 (2015)

Article type

Review paper

Pages

189-200

Published online

2015-09-04

DOI

10.5603/fhc.a2015.0023

Pubmed

26339984

Bibliographic record

Folia Histochem Cytobiol 2015;53(3):189-200.

Keywords

PPARs
ovary
uterus
placenta
reproduction
estrous cycle
pregnancy

Authors

Iwona Bogacka
Aleksandra Kurzynska
Marek Bogacki
Katarzyna Chojnowska

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