open access

Vol 53, No 2 (2015)
Review paper
Submitted: 2014-11-08
Accepted: 2015-07-02
Published online: 2015-07-07
Get Citation

The role of periostin in neoplastic processes

Katarzyna Ratajczak-Wielgomas, Piotr Dziegiel
DOI: 10.5603/FHC.a2015.0014
·
Pubmed: 26150285
·
Folia Histochem Cytobiol 2015;53(2):120-132.

open access

Vol 53, No 2 (2015)
REVIEW
Submitted: 2014-11-08
Accepted: 2015-07-02
Published online: 2015-07-07

Abstract

Periostin, also called osteoblast-specific factor 2 (OSF-2), is a multifunctional glycoprotein that belongs to the group of matricellular proteins. Due to its characteristic molecular structure containing integrin-binding domains, periostin is capable of binding to multiple integrin receptors (αvβ3, αvβ5, α6β4), thus affecting the regulation of the intracellular signaling pathways associated with protein kinases PI3K/AKT and focal adhesion kinase (FAK). This protein thus plays a role in the adhesion process, in the migration of many cells, and importantly, epithelial-mesenchymal transition of cancer cells. Periostin also participates in the processes of angiogenesis and lymphangiogenesis, metastases of cancer cells, and remodeling of the extracellular matrix. Increased expression of periostin has been observed in various tumor types, including breast, NSCLC, colorectal, pancreatic, prostate, and ovarian cancers, as well as tumors of the head and neck, and glioblastomas. Many groups have recently reported on periostin’s key role in tumor progression, which suggests that periostin can be considered a potential therapeutic target.

Abstract

Periostin, also called osteoblast-specific factor 2 (OSF-2), is a multifunctional glycoprotein that belongs to the group of matricellular proteins. Due to its characteristic molecular structure containing integrin-binding domains, periostin is capable of binding to multiple integrin receptors (αvβ3, αvβ5, α6β4), thus affecting the regulation of the intracellular signaling pathways associated with protein kinases PI3K/AKT and focal adhesion kinase (FAK). This protein thus plays a role in the adhesion process, in the migration of many cells, and importantly, epithelial-mesenchymal transition of cancer cells. Periostin also participates in the processes of angiogenesis and lymphangiogenesis, metastases of cancer cells, and remodeling of the extracellular matrix. Increased expression of periostin has been observed in various tumor types, including breast, NSCLC, colorectal, pancreatic, prostate, and ovarian cancers, as well as tumors of the head and neck, and glioblastomas. Many groups have recently reported on periostin’s key role in tumor progression, which suggests that periostin can be considered a potential therapeutic target.

Get Citation

Keywords

periostin; epithelial mesenchymal transition; cancer; metastasis

About this article
Title

The role of periostin in neoplastic processes

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 53, No 2 (2015)

Article type

Review paper

Pages

120-132

Published online

2015-07-07

DOI

10.5603/FHC.a2015.0014

Pubmed

26150285

Bibliographic record

Folia Histochem Cytobiol 2015;53(2):120-132.

Keywords

periostin
epithelial mesenchymal transition
cancer
metastasis

Authors

Katarzyna Ratajczak-Wielgomas
Piotr Dziegiel

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