Vol 51, No 3 (2013)
Original paper
Submitted: 2013-04-09
Accepted: 2013-07-25
Published online: 2013-11-07
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Immunohistochemical expression of MMP-7 protein and its serum level in colorectal cancer

Anna Pryczynicz, Mariusz Gryko, Katarzyna Niewiarowska, Violetta Dymicka-Piekarska, Marek Ustymowicz, Maciej Hawryluk, Dariusz Cepowicz, Agnieszka Borsuk, Andrzej Kemona, Waldemar Famulski, Katarzyna Guzinska-Ustymowicz
DOI: 10.5603/FHC.2013.0029
·
Folia Histochem Cytobiol 2013;51(3):206-212.
Vol 51, No 3 (2013)
ORIGINAL PAPERS
Submitted: 2013-04-09
Accepted: 2013-07-25
Published online: 2013-11-07

Abstract

The study objective was to determine the presence of MMP-7 in cancer tissue in correlation with its serum level in patients diagnosed with colorectal cancer (CRC). In 45 patients with CRC, MMP-7 expression was assessed immunohistochemically on FFPE slides in tumours (N = 37) and in the corresponding surgical margin sample. MMP-7 serum level was measured preoperatively. The expression of MMP-7 in cancer tissue was much stronger as compared to the normal intestinal mucosa. Also the level of MMP-7 in the serum of CRC patients was higher than in healthy subjects (N = 24) (p < 0.01). The tumour located in the colon showed higher expression of MMP-7 than CRCs located in the rectum (p < 0.05), whereas the higher MMP-7 serum level showed correlation with older age (p = 0.005), tumour size less than 5 cm (p < 0.05), higher Dukes’ stage (p < 0.05) and distant metastases (p < 0.05). The increased serum level of MMP-7 in CRC patients may indicate the presence of distant metastases.

Abstract

The study objective was to determine the presence of MMP-7 in cancer tissue in correlation with its serum level in patients diagnosed with colorectal cancer (CRC). In 45 patients with CRC, MMP-7 expression was assessed immunohistochemically on FFPE slides in tumours (N = 37) and in the corresponding surgical margin sample. MMP-7 serum level was measured preoperatively. The expression of MMP-7 in cancer tissue was much stronger as compared to the normal intestinal mucosa. Also the level of MMP-7 in the serum of CRC patients was higher than in healthy subjects (N = 24) (p < 0.01). The tumour located in the colon showed higher expression of MMP-7 than CRCs located in the rectum (p < 0.05), whereas the higher MMP-7 serum level showed correlation with older age (p = 0.005), tumour size less than 5 cm (p < 0.05), higher Dukes’ stage (p < 0.05) and distant metastases (p < 0.05). The increased serum level of MMP-7 in CRC patients may indicate the presence of distant metastases.

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Keywords

colorectal cancer; matrix metalloproteinase-7; metastasis; serum level; colon; rectum

About this article
Title

Immunohistochemical expression of MMP-7 protein and its serum level in colorectal cancer

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 51, No 3 (2013)

Article type

Original paper

Pages

206-212

Published online

2013-11-07

DOI

10.5603/FHC.2013.0029

Bibliographic record

Folia Histochem Cytobiol 2013;51(3):206-212.

Keywords

colorectal cancer
matrix metalloproteinase-7
metastasis
serum level
colon
rectum

Authors

Anna Pryczynicz
Mariusz Gryko
Katarzyna Niewiarowska
Violetta Dymicka-Piekarska
Marek Ustymowicz
Maciej Hawryluk
Dariusz Cepowicz
Agnieszka Borsuk
Andrzej Kemona
Waldemar Famulski
Katarzyna Guzinska-Ustymowicz

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