open access

Vol 50, No 4 (2012)
Original paper
Submitted: 2012-12-23
Accepted: 2012-12-23
Published online: 2012-12-23
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Immunohistochemical expression and distribution of orexin, orphanin and leptin in the major salivary glands of some mammals

Angelo Leone, Giovanni Francesco Spatola, Daniela Cucco, Vincenzo Tessitore, Giuseppe Bonaventura, Maria Laura Uzzo
DOI: 10.5603/FHC.2012.0071
·
Folia Histochem Cytobiol 2012;50(4):504-512.

open access

Vol 50, No 4 (2012)
ORIGINAL PAPERS
Submitted: 2012-12-23
Accepted: 2012-12-23
Published online: 2012-12-23

Abstract

The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and
orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow. These
peptides, originally synthesized in central nervous system, adipose tissue and peripheral tissues including gastrointestinal
tract, play an orexigenic (orphanin and orexin) or anorexigenic (leptin) roles in the intricate neuronal
network appointed to the control of nutritional homeostasis. Peptide-specific immunoreactivity was present
in the studied salivary glands with various intensities in different species, in the ductal epithelium, sometimes in
the acinar epithelium, and in nervous trunks spread in connective tissue stroma. The obtained data show that
salivary glands present an unexpected source of orexigenic and anorexigenic peptides which with their autocrine,
paracrine, and endocrine mechanisms of action may participate in the control of salivary gland function.

Abstract

The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and
orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow. These
peptides, originally synthesized in central nervous system, adipose tissue and peripheral tissues including gastrointestinal
tract, play an orexigenic (orphanin and orexin) or anorexigenic (leptin) roles in the intricate neuronal
network appointed to the control of nutritional homeostasis. Peptide-specific immunoreactivity was present
in the studied salivary glands with various intensities in different species, in the ductal epithelium, sometimes in
the acinar epithelium, and in nervous trunks spread in connective tissue stroma. The obtained data show that
salivary glands present an unexpected source of orexigenic and anorexigenic peptides which with their autocrine,
paracrine, and endocrine mechanisms of action may participate in the control of salivary gland function.
Get Citation
About this article
Title

Immunohistochemical expression and distribution of orexin, orphanin and leptin in the major salivary glands of some mammals

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 4 (2012)

Article type

Original paper

Pages

504-512

Published online

2012-12-23

DOI

10.5603/FHC.2012.0071

Bibliographic record

Folia Histochem Cytobiol 2012;50(4):504-512.

Authors

Angelo Leone
Giovanni Francesco Spatola
Daniela Cucco
Vincenzo Tessitore
Giuseppe Bonaventura
Maria Laura Uzzo

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