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Immunohistochemical expression and distribution of orexin, orphanin and leptin in the major salivary glands of some mammals
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Abstract
orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow. These
peptides, originally synthesized in central nervous system, adipose tissue and peripheral tissues including gastrointestinal
tract, play an orexigenic (orphanin and orexin) or anorexigenic (leptin) roles in the intricate neuronal
network appointed to the control of nutritional homeostasis. Peptide-specific immunoreactivity was present
in the studied salivary glands with various intensities in different species, in the ductal epithelium, sometimes in
the acinar epithelium, and in nervous trunks spread in connective tissue stroma. The obtained data show that
salivary glands present an unexpected source of orexigenic and anorexigenic peptides which with their autocrine,
paracrine, and endocrine mechanisms of action may participate in the control of salivary gland function.
Abstract
orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow. These
peptides, originally synthesized in central nervous system, adipose tissue and peripheral tissues including gastrointestinal
tract, play an orexigenic (orphanin and orexin) or anorexigenic (leptin) roles in the intricate neuronal
network appointed to the control of nutritional homeostasis. Peptide-specific immunoreactivity was present
in the studied salivary glands with various intensities in different species, in the ductal epithelium, sometimes in
the acinar epithelium, and in nervous trunks spread in connective tissue stroma. The obtained data show that
salivary glands present an unexpected source of orexigenic and anorexigenic peptides which with their autocrine,
paracrine, and endocrine mechanisms of action may participate in the control of salivary gland function.
About this articleTitle
Immunohistochemical expression and distribution of orexin, orphanin and leptin in the major salivary glands of some mammals
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Original paper
Pages
504-512
Published online
2012-12-23
Page views
1905
Article views/downloads
2792
DOI
10.5603/FHC.2012.0071
Bibliographic record
Folia Histochem Cytobiol 2012;50(4):504-512.
Authors
Angelo Leone
Giovanni Francesco Spatola
Daniela Cucco
Vincenzo Tessitore
Giuseppe Bonaventura
Maria Laura Uzzo
