open access

Vol 50, No 3 (2012)
Original paper
Submitted: 2012-10-08
Accepted: 2012-10-08
Published online: 2012-10-08
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The usefulness of soluble transferrin receptor (sTfR) in differentiating anemia occurring in young children

Barbara Kamer, Elżbieta Dółka, Renata Pasowska, Ewa Świątkowska
DOI: 10.5603/FHC.2012.0066
·
Folia Histochem Cytobiol 2012;50(3):473-479.

open access

Vol 50, No 3 (2012)
ORIGINAL PAPERS
Submitted: 2012-10-08
Accepted: 2012-10-08
Published online: 2012-10-08

Abstract

We evaluated the usefulness of soluble transferrin receptor (sTfR) and of the sTfR/log ferritin index
(sTfR/logF) in the differentiation of anemia in young children. 96 children, aged 6–36 months, were examined.
From these, four groups were distinguished: 1 — (IDA): 33 children with anemia due to iron deficiency; 2 —
(IA): 19 children with infectious anemia without iron deficiency; 3 — (IA + ID): 16 children with infectious
anemia and iron deficiency; and 4 — a comparator group (CG): 28 healthy children without iron deficiency. The
soluble transferrin receptor, hematological indices and iron balance were evaluated and the sTfR/logF was
calculated for each examined child. It was proved that the mean values of sTfR and sTfR/logF were substantially
higher in children with anemia due to iron deficiency, and in those with infectious anemia and iron deficiency,
vs. those with infectious anemia or in healthy children. This suggests that both sTfR and the sTfR/logF are good
indicators of iron deficiency and could be useful in the differential diagnostics of anemia, especially in young
children.

Abstract

We evaluated the usefulness of soluble transferrin receptor (sTfR) and of the sTfR/log ferritin index
(sTfR/logF) in the differentiation of anemia in young children. 96 children, aged 6–36 months, were examined.
From these, four groups were distinguished: 1 — (IDA): 33 children with anemia due to iron deficiency; 2 —
(IA): 19 children with infectious anemia without iron deficiency; 3 — (IA + ID): 16 children with infectious
anemia and iron deficiency; and 4 — a comparator group (CG): 28 healthy children without iron deficiency. The
soluble transferrin receptor, hematological indices and iron balance were evaluated and the sTfR/logF was
calculated for each examined child. It was proved that the mean values of sTfR and sTfR/logF were substantially
higher in children with anemia due to iron deficiency, and in those with infectious anemia and iron deficiency,
vs. those with infectious anemia or in healthy children. This suggests that both sTfR and the sTfR/logF are good
indicators of iron deficiency and could be useful in the differential diagnostics of anemia, especially in young
children.
Get Citation
About this article
Title

The usefulness of soluble transferrin receptor (sTfR) in differentiating anemia occurring in young children

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 3 (2012)

Article type

Original paper

Pages

473-479

Published online

2012-10-08

DOI

10.5603/FHC.2012.0066

Bibliographic record

Folia Histochem Cytobiol 2012;50(3):473-479.

Authors

Barbara Kamer
Elżbieta Dółka
Renata Pasowska
Ewa Świątkowska

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