open access

Vol 50, No 3 (2012)
Original paper
Submitted: 2012-10-08
Accepted: 2012-10-08
Published online: 2012-10-08
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HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma

Joanna Reszeć, Renata Zalewska, Piotr Bernaczyk, Lech Chyczewski
DOI: 10.5603/FHC.2012.0063
·
Folia Histochem Cytobiol 2012;50(3):456-459.

open access

Vol 50, No 3 (2012)
ORIGINAL PAPERS
Submitted: 2012-10-08
Accepted: 2012-10-08
Published online: 2012-10-08

Abstract

Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and
optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal
ganglion cells in 42 eyes enucleated because of complete glaucoma compared to eyes removed because of injury.
The immunohistochemical reaction was done and specimens were examined under a light microscope. 57% of
cases presented HIF-1 expression in the optic nerve axons, and 52.3% in the retinal ganglion cells. 20 out of 42
(47.6%) cases were HIF-1 positive both in the optic nerve axons and in the retinal ganglion cells, and the staining
was evident mostly in the nuclear and perinuclear area. Our present results indicate that HIF-1 expression in
hypoxic conditions in glaucoma might be a very crucial stage in damage to retinal ganglion cells and optic nerve
axons, and might be a successful target for the implementation of neuroprotective drugs.

Abstract

Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and
optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal
ganglion cells in 42 eyes enucleated because of complete glaucoma compared to eyes removed because of injury.
The immunohistochemical reaction was done and specimens were examined under a light microscope. 57% of
cases presented HIF-1 expression in the optic nerve axons, and 52.3% in the retinal ganglion cells. 20 out of 42
(47.6%) cases were HIF-1 positive both in the optic nerve axons and in the retinal ganglion cells, and the staining
was evident mostly in the nuclear and perinuclear area. Our present results indicate that HIF-1 expression in
hypoxic conditions in glaucoma might be a very crucial stage in damage to retinal ganglion cells and optic nerve
axons, and might be a successful target for the implementation of neuroprotective drugs.
Get Citation
About this article
Title

HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 3 (2012)

Article type

Original paper

Pages

456-459

Published online

2012-10-08

DOI

10.5603/FHC.2012.0063

Bibliographic record

Folia Histochem Cytobiol 2012;50(3):456-459.

Authors

Joanna Reszeć
Renata Zalewska
Piotr Bernaczyk
Lech Chyczewski

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