open access

Vol 50, No 3 (2012)
Original paper
Submitted: 2012-10-08
Accepted: 2012-10-08
Published online: 2012-10-08
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Effect of heavy metal cations on the activity of cathepsin D (in vitro study)

Alicja Karwowska, Radosław Łapiński, Marek Gacko, Ewa Grzegorczyk, Joanna Żurawska, Jan K. Karczewski
DOI: 10.5603/FHC.2012.0059
·
Folia Histochem Cytobiol 2012;50(3):432-435.

open access

Vol 50, No 3 (2012)
ORIGINAL PAPERS
Submitted: 2012-10-08
Accepted: 2012-10-08
Published online: 2012-10-08

Abstract

We studied the effect of heavy metal cations: Fe 2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ on the activity of
cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l. Hemoglobin
was the cathepsin D substrate. The activity of cathepsin D was determined at pH 3.5. Only Hg2+ cations
inhibit the activity of cathepsin D. Cations Hg2+ damage lysosomes and release cathepsin D from these organelles.

Abstract

We studied the effect of heavy metal cations: Fe 2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ on the activity of
cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l. Hemoglobin
was the cathepsin D substrate. The activity of cathepsin D was determined at pH 3.5. Only Hg2+ cations
inhibit the activity of cathepsin D. Cations Hg2+ damage lysosomes and release cathepsin D from these organelles.
Get Citation
About this article
Title

Effect of heavy metal cations on the activity of cathepsin D (in vitro study)

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 3 (2012)

Article type

Original paper

Pages

432-435

Published online

2012-10-08

DOI

10.5603/FHC.2012.0059

Bibliographic record

Folia Histochem Cytobiol 2012;50(3):432-435.

Authors

Alicja Karwowska
Radosław Łapiński
Marek Gacko
Ewa Grzegorczyk
Joanna Żurawska
Jan K. Karczewski

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