Vol 50, No 2 (2012)
Review paper
Published online: 2012-07-05

open access

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Biochemical markers of psoriasis as a metabolic disease

Agnieszka Gerkowicz, Aldona Pietrzak, Jacek Cezary Szepietowski, Sebastian Radej, Grażyna Chodorowska
DOI: 10.5603/FHC.2012.0025
Folia Histochem Cytobiol 2012;50(2):155-170.

Abstract

Psoriasis is a chronic immune mediated inflammatory skin disease with a population prevalence of 2–3%. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Many bioactive substances have appeared to be related to metabolic syndrome. Based on current literature, we here discuss the possible role of adiponectin, leptin, ghrelin, resistin, inflammatory cytokines, plasminogen activator inhibitor 1, uric acid, C-reactive protein and lipid abnormalities in psoriasis and in metabolic syndrome.

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