open access

Vol 51, No 2 (2013)
Original paper
Submitted: 2012-06-05
Accepted: 2013-02-08
Published online: 2013-08-02
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Effects of thyroxine treatment during lactation on the testicular function of rats across different ages

Souhila Dahmani-Said, Zohra Hamouli-Said, Assia Kamel, Fatima Hadj-Bekkouche
DOI: 10.5603/FHC.2013.0017
·
Folia Histochem Cytobiol 2013;51(2):107-114.

open access

Vol 51, No 2 (2013)
ORIGINAL PAPERS
Submitted: 2012-06-05
Accepted: 2013-02-08
Published online: 2013-08-02

Abstract

Thyroid hormones are involved in the development of several tissues and organs and are essential for the normal growth and reproductive function. The aim of this study was to determine the effects of thyroid hormones on the development of testis and progression of spermatogenesis. Lactating mothers were treated with oral thyroxine (T4; 20 μg/100 g) for 20 days after parturition. The pups were decapitated at the age of 20, 40 and 60 days post partum. Neonatal hyperthyroidism resulted in a decrease in body and testis mass, an increase of free thyroxine and a decrease of testosterone concentrations in plasma of treated rats. The treatment was associated with a significant decrease of the diameter of seminiferous tubules and a slowdown in spermatogenesis, following a delay in the maturation of germ cells. We conclude that thyroid hormones affect the progression of postnatal spermatogenesis.

Abstract

Thyroid hormones are involved in the development of several tissues and organs and are essential for the normal growth and reproductive function. The aim of this study was to determine the effects of thyroid hormones on the development of testis and progression of spermatogenesis. Lactating mothers were treated with oral thyroxine (T4; 20 μg/100 g) for 20 days after parturition. The pups were decapitated at the age of 20, 40 and 60 days post partum. Neonatal hyperthyroidism resulted in a decrease in body and testis mass, an increase of free thyroxine and a decrease of testosterone concentrations in plasma of treated rats. The treatment was associated with a significant decrease of the diameter of seminiferous tubules and a slowdown in spermatogenesis, following a delay in the maturation of germ cells. We conclude that thyroid hormones affect the progression of postnatal spermatogenesis.

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Keywords

Hyperthyroidism; Sertoli cell; Leydig cell

About this article
Title

Effects of thyroxine treatment during lactation on the testicular function of rats across different ages

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 51, No 2 (2013)

Article type

Original paper

Pages

107-114

Published online

2013-08-02

DOI

10.5603/FHC.2013.0017

Bibliographic record

Folia Histochem Cytobiol 2013;51(2):107-114.

Keywords

Hyperthyroidism
Sertoli cell
Leydig cell

Authors

Souhila Dahmani-Said
Zohra Hamouli-Said
Assia Kamel
Fatima Hadj-Bekkouche

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