The anticancer activity of propolis

Diana Sawicka, Halina Car, Maria Halina Borawska, Jacek Nikliński
DOI: 10.5603/FHC.2012.0004
·
Folia Histochem Cytobiol 2012;50(1):25-37.

open access

Vol 50, No 1 (2012)
REVIEW
Published online: 2012-04-25
Submitted: 2012-04-24
Accepted: 2012-04-24

Abstract

Propolis and its compounds have been the subject of many studies due to their antimicrobial and antiinflammatory activity; however, it is now known that they also possess antitumor properties. This review aims to summarize the results of studies on the mechanism of activity of propolis and its active compounds such as CAPE and chrysin in the apoptotic process, and their influence on the proliferation of cancer cells. Our review shows that propolis and its presented compounds induce apoptosis pathways in cancer cells. The antiproliferative effects of propolis, CAPE or chrysin in cancer cells are the result of the suppression of complexes of cyclins, as well as cell cycle arrest. The results of in vitro and in vivo studies suggest that propolis, CAPE and chrysin may inhibit tumor cell progression and may be useful as potential chemotherapeutic or chemopreventive anticancer drugs.

Keywords

cancer; propolis; CAPE; chrysin; apoptosis; proliferation

About this article
Title

The anticancer activity of propolis

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 1 (2012)

Pages

25-37

Published online

2012-04-25

DOI

10.5603/FHC.2012.0004

Bibliographic record

Folia Histochem Cytobiol 2012;50(1):25-37.

Keywords

cancer
propolis
CAPE
chrysin
apoptosis
proliferation

Authors

Diana Sawicka
Halina Car
Maria Halina Borawska
Jacek Nikliński

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