open access

Vol 50, No 1 (2012)
Review paper
Submitted: 2012-04-24
Accepted: 2012-04-24
Published online: 2012-04-24
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Alcohol abuse and glycoconjugate metabolism

Napoleon Waszkiewicz, Sławomir Dariusz Szajda, Anna Zalewska, Agata Szulc, Alina Kępka, Alina Minarowska, Marzena Wojewódzka-Żelezniakowicz, Beata Konarzewska, Sylwia Chojnowska, Jerzy Robert Ładny, Krzysztof Zwierz
DOI: 10.5603/FHC.2012.0001
·
Folia Histochem Cytobiol 2012;50(1):1-11.

open access

Vol 50, No 1 (2012)
REVIEW
Submitted: 2012-04-24
Accepted: 2012-04-24
Published online: 2012-04-24

Abstract

The relationship between alcohol consumption and glycoconjugate metabolism is complex and multidimensional. This review summarizes the advances in basic and clinical research on the molecular and cellular events involved in the metabolic effects of alcohol on glycoconjugates (glycoproteins, glycolipids, and proteoglycans). We summarize the action of ethanol, acetaldehyde, reactive oxygen species (ROS), nonoxidative metabolite of alcohol — fatty acid ethyl esters (FAEEs), and the ethanol-water competition mechanism, on glycoconjugate biosynthesis, modification, transport and secretion, as well as on elimination and catabolism processes. As the majority of changes in the cellular metabolism of glycoconjugates are generally ascribed to alterations in synthesis, transport, glycosylation and secretion, the degradation and elimination processes, of which the former occurs also in extracellular matrix, seem to be underappreciated. The pathomechanisms are additionally complicated by the fact that the effect of alcohol intoxication on the glycoconjugate metabolism depends not only on the duration of ethanol exposure, but also demonstrates dose- and regional-sensitivity. Further research is needed to bridge the gap in transdisciplinary research and enhance our understanding of alcohol- and glycoconjugate-related diseases.

Abstract

The relationship between alcohol consumption and glycoconjugate metabolism is complex and multidimensional. This review summarizes the advances in basic and clinical research on the molecular and cellular events involved in the metabolic effects of alcohol on glycoconjugates (glycoproteins, glycolipids, and proteoglycans). We summarize the action of ethanol, acetaldehyde, reactive oxygen species (ROS), nonoxidative metabolite of alcohol — fatty acid ethyl esters (FAEEs), and the ethanol-water competition mechanism, on glycoconjugate biosynthesis, modification, transport and secretion, as well as on elimination and catabolism processes. As the majority of changes in the cellular metabolism of glycoconjugates are generally ascribed to alterations in synthesis, transport, glycosylation and secretion, the degradation and elimination processes, of which the former occurs also in extracellular matrix, seem to be underappreciated. The pathomechanisms are additionally complicated by the fact that the effect of alcohol intoxication on the glycoconjugate metabolism depends not only on the duration of ethanol exposure, but also demonstrates dose- and regional-sensitivity. Further research is needed to bridge the gap in transdisciplinary research and enhance our understanding of alcohol- and glycoconjugate-related diseases.
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Keywords

ethanol; alkohol; glycoconjugate; metabolism

About this article
Title

Alcohol abuse and glycoconjugate metabolism

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 1 (2012)

Article type

Review paper

Pages

1-11

Published online

2012-04-24

DOI

10.5603/FHC.2012.0001

Bibliographic record

Folia Histochem Cytobiol 2012;50(1):1-11.

Keywords

ethanol
alkohol
glycoconjugate
metabolism

Authors

Napoleon Waszkiewicz
Sławomir Dariusz Szajda
Anna Zalewska
Agata Szulc
Alina Kępka
Alina Minarowska
Marzena Wojewódzka-Żelezniakowicz
Beata Konarzewska
Sylwia Chojnowska
Jerzy Robert Ładny
Krzysztof Zwierz

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