open access

Vol 50, No 4 (2012)
Original paper
Submitted: 2012-02-07
Accepted: 2012-06-30
Published online: 2012-12-23
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Hsp-27 Expression in Invasive Ductal Breast Carcinoma

Jędrzej Grzegrzółka, Krzysztof Kurnol, Paweł Piotrów, Bartosz Puła, Christopher Kobierzycki, Aleksandra Piotrowska, Karolina Jabłońska, Andrzej Wojnar, Janusz Ryś, Piotr Dzięgiel, Marzena Podhorska- Okołów
DOI: 10.5603/FHC.2012.0074
·
Folia Histochem Cytobiol 2012;50(4):527-533.

open access

Vol 50, No 4 (2012)
ORIGINAL PAPERS
Submitted: 2012-02-07
Accepted: 2012-06-30
Published online: 2012-12-23

Abstract

The aim of this study was to determine the intensity of Hsp-27 protein expression in fibrocystic breast changes (FC) and invasive ductal breast carcinoma (IDC) and to examine its impact on patients’ clinico-pathological characteristics and overall survival. Immunohistochemical reactions were conducted on archival samples of 20 cases of FC and 101 cases of IDC treated in the years 1999-2002. Nuclear-cytoplasmic Hsp-27 expression was observed in 92 (92.1%) of the examined cases of IDC and all the cases of FC. Significantly higher Hsp-27 expression was observed in G2 (p<0.01) and G3 cases (p<0.0001) as compared to FC. HER-2 positive cases had higher Hsp-27 expression (p=0.0153), than HER-2 negative cases. Our research showed that Hsp-27 could have a impact on tumour malignancy. Moreover, the positive correlation between expression of Hsp-27 and HER-2 positive cases was demonstrated.

Abstract

The aim of this study was to determine the intensity of Hsp-27 protein expression in fibrocystic breast changes (FC) and invasive ductal breast carcinoma (IDC) and to examine its impact on patients’ clinico-pathological characteristics and overall survival. Immunohistochemical reactions were conducted on archival samples of 20 cases of FC and 101 cases of IDC treated in the years 1999-2002. Nuclear-cytoplasmic Hsp-27 expression was observed in 92 (92.1%) of the examined cases of IDC and all the cases of FC. Significantly higher Hsp-27 expression was observed in G2 (p<0.01) and G3 cases (p<0.0001) as compared to FC. HER-2 positive cases had higher Hsp-27 expression (p=0.0153), than HER-2 negative cases. Our research showed that Hsp-27 could have a impact on tumour malignancy. Moreover, the positive correlation between expression of Hsp-27 and HER-2 positive cases was demonstrated.

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Keywords

breast cancer; hsp-27; heat shock protein

About this article
Title

Hsp-27 Expression in Invasive Ductal Breast Carcinoma

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 4 (2012)

Article type

Original paper

Pages

527-533

Published online

2012-12-23

DOI

10.5603/FHC.2012.0074

Bibliographic record

Folia Histochem Cytobiol 2012;50(4):527-533.

Keywords

breast cancer
hsp-27
heat shock protein

Authors

Jędrzej Grzegrzółka
Krzysztof Kurnol
Paweł Piotrów
Bartosz Puła
Christopher Kobierzycki
Aleksandra Piotrowska
Karolina Jabłońska
Andrzej Wojnar
Janusz Ryś
Piotr Dzięgiel
Marzena Podhorska- Okołów

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