Mast cells evaluation in meningioma of various grades

Abstract

Introduction: Meningioma is a heterogenous group of primary brain tumors. The progression or recurrence is relatively very common; however there is lack of prognostic factors which may indicate those events. The aim of the study was to evaluate the presence of mast cells within the low grade and high grade meningiomas.

Material and Methods: The immunohistochemical reaction was done. The tryptase expression was estimated in slides of meningiomas of various grades in 10 random fields under the light microscope.

Results: The expression of tryptase was observed in 31,8% low grade meningiomas and in 85,9% high grade meningiomas. The immunostaining was observed next to the blood vessels.

Conclusion: The presence of mast cells might be a significant prognostic factor for the recurrence or the worse prognosis of meningiomas.