open access
Mast cells evaluation in meningioma of various grades
open access
Abstract
Introduction: Meningioma is a heterogenous group of primary brain tumors. The progression or recurrence is relatively very common; however there is lack of prognostic factors which may indicate those events. The aim of the study was to evaluate the presence of mast cells within the low grade and high grade meningiomas.
Material and Methods: The immunohistochemical reaction was done. The tryptase expression was estimated in slides of meningiomas of various grades in 10 random fields under the light microscope.
Results: The expression of tryptase was observed in 31,8% low grade meningiomas and in 85,9% high grade meningiomas. The immunostaining was observed next to the blood vessels.
Conclusion: The presence of mast cells might be a significant prognostic factor for the recurrence or the worse prognosis of meningiomas.
Abstract
Introduction: Meningioma is a heterogenous group of primary brain tumors. The progression or recurrence is relatively very common; however there is lack of prognostic factors which may indicate those events. The aim of the study was to evaluate the presence of mast cells within the low grade and high grade meningiomas.
Material and Methods: The immunohistochemical reaction was done. The tryptase expression was estimated in slides of meningiomas of various grades in 10 random fields under the light microscope.
Results: The expression of tryptase was observed in 31,8% low grade meningiomas and in 85,9% high grade meningiomas. The immunostaining was observed next to the blood vessels.
Conclusion: The presence of mast cells might be a significant prognostic factor for the recurrence or the worse prognosis of meningiomas.
Keywords
meningioma; mast cell; tryptase
About this articleTitle
Mast cells evaluation in meningioma of various grades
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Original paper
Pages
542-546
Published online
2012-12-23
Page views
1930
Article views/downloads
2351
DOI
10.5603/FHC.2012.0076
Bibliographic record
Folia Histochem Cytobiol 2012;50(4):542-546.
Keywords
meningioma
mast cell
tryptase
Authors
Joanna Reszeć
Adam Hermanowicz
Jan Kochanowicz
Grzegorz Turek
Zenon Mariak
Lech Chyczewski
