Vol 49, No 4 (2011)
Original paper
Published online: 2012-01-16
The prognostic significance of the immunohistochemical expression of P53 and BCL-2 in endometrial cancer
DOI: 10.5603/FHC.2011.0086
Folia Histochem Cytobiol 2011;49(4):631-635.
Abstract
The objective of this study was to verify the frequency of P53 and BCL-2 immunohistochemical expression
in 98 patients with endometrial carcinoma, and to correlate it with clinical stage and patient survival.
A significant difference was found regarding the frequency of P53 expression when comparing type I and II tumors
(23.7% and 54.5%, respectively; p = 0.006). A positive correlation was observed between P53 immunoexpression
and patient survival in type I and II tumors (p = 0.009 and p = 0.036, respectively). BCL-2 expression was
significantly more frequent in early clinical stages in both types of endometrial cancer (p < 0.001 and 0.002) and
correlated with a decrease in overall survival in type I endometrial cancer (p = 0.014). Thus, the prognostic
value of these biomarkers in endometrial cancer needs to be further investigated. (Folia Histochemica et Cytobiologica
2011; Vol. 49, No. 4, pp. 631–635)
Keywords: endometrial cancerP53BCL-2prognosis
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