Digital pathology in personalized cancer therapy

Janina Słodkowska, Marcial Garcia Rojo
DOI: 10.5603/FHC.2011.0080
Folia Histochem Cytobiol 2011;49(4):570-578.

open access

Vol 49, No 4 (2011)
Published online: 2012-01-16
Submitted: 2012-01-16


The development of small molecule inhibitors of growth factor receptors, and the discovery of somatic mutations of the thyrosine kinase domain, have resulted in new paradigms for cancer therapy. Digital microscopy is an important tool for surgical pathologists. The achievements in the digital pathology field have modified the workflow of pathomorphology labs, enhanced the pathologist’s role in diagnostics, and increased their contribution to personalized targeted medicine. Digital image analysis is now available in a variety of platforms to improve quantification performance of diagnostic pathology. We here describe the state of digital microscopy as it applies to the field of quantitative immunohistochemistry of biomarkers related to the clinical personalized targeted therapy of breast cancer, non-small lung cancer and colorectal cancer: HER-2, EGFR, KRAS and BRAF genes. The information is derived from the experience of the authors and a review of the literature. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 570–578)


digital pathology; immunohistochemistry; IHC biomarkers; breast cancer; NSCLC; personalized targeted therapy; EGFR; HER-2; telepathology systems; quantitative analysis

About this article

Digital pathology in personalized cancer therapy


Folia Histochemica et Cytobiologica


Vol 49, No 4 (2011)



Published online




Bibliographic record

Folia Histochem Cytobiol 2011;49(4):570-578.


digital pathology
IHC biomarkers
breast cancer
personalized targeted therapy
telepathology systems
quantitative analysis


Janina Słodkowska
Marcial Garcia Rojo

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