Vol 14, No 3 (2019)
Case report
Published online: 2019-07-04
Amiodarone — thyroid — arrhythmia. Difficult cooperation between endocrinologist and cardiologist. A patient with amiodarone-induced thyroid disturbances
DOI: 10.5603/FC.2019.0062
Folia Cardiologica 2019;14(3):294-297.
Abstract
We present the case of a patient with atrial flutter (treated with cryoablation) and amiodarone-induced hypothyroidism (AIH). Administration of l-tyroxine supplementation triggered recurrence of arrhythmia. The report shows how difficult can be treating a patient with AIH and how important is cooperation between cardiologist and endocrinologist.
Keywords: amiodaroneatrial flutterhypothyroidismAIH
References
- O'Sullivan AJ, Lewis M, Diamond T. Amiodarone-induced thyrotoxicosis: left ventricular dysfunction is associated with increased mortality. Eur J Endocrinol. 2006; 154(4): 533–536.
- Bogazzi F, Bartalena L, Martino E. Approach to the patient with amiodarone-induced thyrotoxicosis. J Clin Endocrinol Metab. 2010; 95(6): 2529–2535.
- Yamato M, Wada K, Hayashi T, et al. Association between Serum Amiodarone and N-Desethylamiodarone Concentrations and Development of Thyroid Dysfunction. Clin Drug Investig. 2018; 38(1): 39–48.
- Fabre G, Julian B, Saint-Aubert B, et al. Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions. Drug Metab Dispos. 1993; 21(6): 978–985.
