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Cardiometabolic risk factors in young women with macroprolactinaemia
, 23, 1
Affiliations- Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
- Division of Pathophysiology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Zabrze, Poland
- Endocrinological Ward, Third Provincial Hospital, Rybnik, Poland
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Abstract
Introduction: The predominance of high-molecular-weight forms of prolactin in plasma is referred to as macroprolactinaemia. Unlike monomeric hyperprolactinaemia, no previous study has investigated cardiometabolic risk factors in subjects with elevated macroprolactin content.
Material and methods: We studied two age-, weight-, and blood pressure-matched groups of premenopausal women: 11 women with macroprolactinaemia and 11 women with prolactin levels within the reference range. The outcomes of interest included: glucose homeostasis markers, plasma lipids, as well as plasma levels of uric acid, high-sensitivity C-reactive protein (hsCRP), fibrinogen, homocysteine, and 25-hydroxyvitamin D.
Results: Circulating levels of hsCRP and 2-h postchallenge plasma glucose, as well as the homeostatic model assessment 1 of insulin resistance ratio, were higher, while levels of HDL cholesterol and 25-hydroxyvitamin D were lower in women with macroprolactinaemia than in women without elevated levels of prolactin. In women with elevated levels of big-big prolactin, values of hsCRP and 25-hydroxyvitamin D correlated with the degree of insulin resistance and, similarly to HDL cholesterol and 2-h postchallenge plasma glucose, with macroprolactin content. There were no differences between the study groups in concentrations of fasting glucose, total cholesterol, LDL cholesterol, triglycerides, uric acid, fibrinogen, and homocysteine.
Conclusions: The obtained results indicate that young women with macroprolactinaemia seem to be characterised by slightly increased cardiometabolic risk.
Abstract
Introduction: The predominance of high-molecular-weight forms of prolactin in plasma is referred to as macroprolactinaemia. Unlike monomeric hyperprolactinaemia, no previous study has investigated cardiometabolic risk factors in subjects with elevated macroprolactin content.
Material and methods: We studied two age-, weight-, and blood pressure-matched groups of premenopausal women: 11 women with macroprolactinaemia and 11 women with prolactin levels within the reference range. The outcomes of interest included: glucose homeostasis markers, plasma lipids, as well as plasma levels of uric acid, high-sensitivity C-reactive protein (hsCRP), fibrinogen, homocysteine, and 25-hydroxyvitamin D.
Results: Circulating levels of hsCRP and 2-h postchallenge plasma glucose, as well as the homeostatic model assessment 1 of insulin resistance ratio, were higher, while levels of HDL cholesterol and 25-hydroxyvitamin D were lower in women with macroprolactinaemia than in women without elevated levels of prolactin. In women with elevated levels of big-big prolactin, values of hsCRP and 25-hydroxyvitamin D correlated with the degree of insulin resistance and, similarly to HDL cholesterol and 2-h postchallenge plasma glucose, with macroprolactin content. There were no differences between the study groups in concentrations of fasting glucose, total cholesterol, LDL cholesterol, triglycerides, uric acid, fibrinogen, and homocysteine.
Conclusions: The obtained results indicate that young women with macroprolactinaemia seem to be characterised by slightly increased cardiometabolic risk.
Keywords
cardiovascular risk; macroprolactin; monomeric prolactin; risk factors
About this articleTitle
Cardiometabolic risk factors in young women with macroprolactinaemia
Journal
Issue
Article type
Original paper
Pages
336-341
Published online
2019-03-07
Page views
1311
Article views/downloads
837
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2019;70(4):336-341.
Keywords
cardiovascular risk
macroprolactin
monomeric prolactin
risk factors
Authors
Robert Krysiak
Bogdan Marek
Bogusław Okopień
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