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The role of adiponectin and leptin in the treatment of ovarian cancer patients
Affiliations- Oncological Ward, Independent Public Health Care Unit, Voivodeship Specialized Hospital No. 3, Rybnik, Poland
- Department of Physiology, School of Medicine with the Division of Dentistry, Zabrze, Poland
- Department of Toxicology and Addiction, Public Health Faculty, Bytom, Poland
- Urological Ward, Independent Public Health Care Unit, Voivodeship Specialised Hospital No. 3, Rybnik, Poland
- Jan Grodek Vocational State School, Medical Institute, Sanok, Poland
- Endocrynological Ward, Independent Public Health Care Unit, Voivodeship Specialized Hospital No 3, Rybnik, Poland
- Department of Pharmacology, Opole University, Opole, Poland
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Abstract
Introduction: Ovarian cancer is most frequently detected in the advanced stage. Although its pathogenesis is not fully elucidated, it is assumed that body susceptibility and hormonal disorders are responsible. The role of some cytokines as predictors in the treatment process is still investigated. The aim of the study was to determine the relationship of adiponectin and leptin with the disease severity and response to chemotherapy.
Material and methods: Forty-three ovarian cancer patients were treated by systemic treatment. Patients received 5–7 cycles of chemotherapy — paclitaxel/carboplatin with or without bevacizumab. Using standard ELISA kits before and after chemotherapy, adiponectin and leptin concentrations were determined in the blood serum.
Results: The average adiponectin concentration before chemotherapy was found to be 8.83 ± 3.19 μg/ml, as compared to 10.37 ± 4.18 μg/ml (increase by 17.44%, p < 0.001) after treatment. Mean pre-treatment leptin concentration was 16.89 ± 15.54 ng/ml, and 21.77 ± 14.69 ng/ml after chemotherapy (increase by 28.89%, p < 0.01). A positive correlation was found between leptin concentration and age and BMI. There was no relationship of the disease severity with the response to treatment and the concentration of the adipokines. The leptin/adiponectin ratio (L/A) before treatment correlated with better response to chemotherapy.
Conclusions: Adiponectin and leptin did not correlate with the stage of ovarian cancer and response to chemotherapy. The L/A ratio may be considered a predictor of clinical response to treatment.
Abstract
Introduction: Ovarian cancer is most frequently detected in the advanced stage. Although its pathogenesis is not fully elucidated, it is assumed that body susceptibility and hormonal disorders are responsible. The role of some cytokines as predictors in the treatment process is still investigated. The aim of the study was to determine the relationship of adiponectin and leptin with the disease severity and response to chemotherapy.
Material and methods: Forty-three ovarian cancer patients were treated by systemic treatment. Patients received 5–7 cycles of chemotherapy — paclitaxel/carboplatin with or without bevacizumab. Using standard ELISA kits before and after chemotherapy, adiponectin and leptin concentrations were determined in the blood serum.
Results: The average adiponectin concentration before chemotherapy was found to be 8.83 ± 3.19 μg/ml, as compared to 10.37 ± 4.18 μg/ml (increase by 17.44%, p < 0.001) after treatment. Mean pre-treatment leptin concentration was 16.89 ± 15.54 ng/ml, and 21.77 ± 14.69 ng/ml after chemotherapy (increase by 28.89%, p < 0.01). A positive correlation was found between leptin concentration and age and BMI. There was no relationship of the disease severity with the response to treatment and the concentration of the adipokines. The leptin/adiponectin ratio (L/A) before treatment correlated with better response to chemotherapy.
Conclusions: Adiponectin and leptin did not correlate with the stage of ovarian cancer and response to chemotherapy. The L/A ratio may be considered a predictor of clinical response to treatment.
Keywords
adiponectin; leptin; chemotherapy; ovarian neoplasm
About this articleTitle
The role of adiponectin and leptin in the treatment of ovarian cancer patients
Journal
Issue
Article type
Original paper
Pages
57-63
Published online
2018-10-30
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1924
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1322
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2019;70(1):57-63.
Keywords
adiponectin
leptin
chemotherapy
ovarian neoplasm
Authors
Grzegorz J. Słomian
Damian Nowak
Marta Buczkowska
Anna Głogowska-Gruszka
Szymon P. Słomian
Wojciech Roczniak
Szymon Janyga
Przemysław Nowak
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