open access

Vol 67, No 4 (2016)
Review paper
Submitted: 2016-04-06
Accepted: 2016-05-02
Published online: 2016-07-06
Get Citation

Growth hormone, insulin-like growth factor system and carcinogenesis

Cesar Luiz Boguszewski, Margaret Cristina da Silva Boguszewski, John J. Kopchick
·
Pubmed: 27387246
·
Endokrynol Pol 2016;67(4):414-426.

open access

Vol 67, No 4 (2016)
Review Article
Submitted: 2016-04-06
Accepted: 2016-05-02
Published online: 2016-07-06

Abstract

The growth hormone (GH) and insulin-like growth factor (IGF) system plays an important role in the regulation of cell proliferation, differentiation, apoptosis, and angiogenesis. In terms of cell cycle regulation, the GH-IGF system induces signalling pathways for cell growth that compete with other signalling systems that result in cell death; thus the final effect of these opposed forces is critical for normal and abnormal cell growth. The association of the GH-IGF system with carcinogenesis has long been hypothesised, mainly based on in vitro studies and the use of a variety of animal models of human cancer, and also on epidemiological and clinical evidence in humans. While ample experimental evidence supports a role of the GH-IGF system in tumour promotion and progression, with several of its components being currently tested as central targets for cancer therapy, the strength of evidence from patients with acromegaly, GH deficiency, or treated with GH is much weaker. In this review, we will attempt to consolidate this data. (Endokrynol Pol 2016; 67 (4): 414–426)

Abstract

The growth hormone (GH) and insulin-like growth factor (IGF) system plays an important role in the regulation of cell proliferation, differentiation, apoptosis, and angiogenesis. In terms of cell cycle regulation, the GH-IGF system induces signalling pathways for cell growth that compete with other signalling systems that result in cell death; thus the final effect of these opposed forces is critical for normal and abnormal cell growth. The association of the GH-IGF system with carcinogenesis has long been hypothesised, mainly based on in vitro studies and the use of a variety of animal models of human cancer, and also on epidemiological and clinical evidence in humans. While ample experimental evidence supports a role of the GH-IGF system in tumour promotion and progression, with several of its components being currently tested as central targets for cancer therapy, the strength of evidence from patients with acromegaly, GH deficiency, or treated with GH is much weaker. In this review, we will attempt to consolidate this data. (Endokrynol Pol 2016; 67 (4): 414–426)

Get Citation

Keywords

growth hormone; insulin-like growth factor; cancer; carcinogenesis

About this article
Title

Growth hormone, insulin-like growth factor system and carcinogenesis

Journal

Endokrynologia Polska

Issue

Vol 67, No 4 (2016)

Article type

Review paper

Pages

414-426

Published online

2016-07-06

Page views

2762

Article views/downloads

3198

DOI

10.5603/EP.a2016.0053

Pubmed

27387246

Bibliographic record

Endokrynol Pol 2016;67(4):414-426.

Keywords

growth hormone
insulin-like growth factor
cancer
carcinogenesis

Authors

Cesar Luiz Boguszewski
Margaret Cristina da Silva Boguszewski
John J. Kopchick

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą jest  VM Media Group sp. z o.o., Grupa Via Medica, ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl