open access

Vol 75, No 2 (2024)
Review paper
Submitted: 2023-09-05
Accepted: 2024-01-06
Published online: 2024-03-13
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Modifiable risk factors for thyroid cancer: lifestyle and residence environment

Yi Shen12, Xian Wang12, Lu Wang23, Dandan Xiong23, Cailian Wu24, Liting Cen24, Lianguang Xie24, Xiangzhi Li124
·
Pubmed: 38497372
·
Endokrynol Pol 2024;75(2):119-129.
Affiliations
  1. Department of Public Health and Management, Youjiang Medical University for Nationalities, Baise, Guangxi, China
  2. Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumour, The Second Affiliated Hospital of Guangxi University
  3. Department of Science, School of Medicine, Guangxi University of Science and Technology, Liuzhou, Guangxi, China
  4. Department of Public Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou, Guangxi, China

open access

Vol 75, No 2 (2024)
Review Article
Submitted: 2023-09-05
Accepted: 2024-01-06
Published online: 2024-03-13

Abstract

In recent years, there has been a rapid increase in the prevalence of benign and malignant tumours of the thyroid gland worldwide, positioning it as one of the most prevalent neoplasms within the endocrine system. While the pathogenesis of thyroid tumours is still unclear, an increasing number of studies have found that certain lifestyle and residence environments are associated with their occurrence and development. This article endeavours to elucidate the correlation between lifestyle, residential environment, and the increased prevalence of thyroid cancer in recent years. It specifies the frequency of the lifestyle and outlines the scope of the residential environment.

It also endeavours to summarise the main mechanistic pathways of various modifiable risk factors that cause thyroid cancer. Factors that prevent thyroid cancer include smoking and alcohol consumption, quality and regular sleep, consumption of cruciferous vegetables and dairy products, and consistent long-term exercise. Conversely, individuals with specific genetic mutations have an elevated risk of thyroid cancer from prolonged and frequent use of mobile phones. In addition, individuals who work in high-pressure jobs, work night shifts, and live near volcanoes or in environments associated with pesticides have an elevated risk of developing thyroid cancer.

The impact of living near a nuclear power plant on thyroid cancer remains inconclusive. Raising awareness of modifiable risk factors for thyroid cancer will help to accurately prevent and control thyroid cancer. It will provide a scientific basis for future research on lifestyles and living environments suitable for people at high risk of thyroid cancer.

Abstract

In recent years, there has been a rapid increase in the prevalence of benign and malignant tumours of the thyroid gland worldwide, positioning it as one of the most prevalent neoplasms within the endocrine system. While the pathogenesis of thyroid tumours is still unclear, an increasing number of studies have found that certain lifestyle and residence environments are associated with their occurrence and development. This article endeavours to elucidate the correlation between lifestyle, residential environment, and the increased prevalence of thyroid cancer in recent years. It specifies the frequency of the lifestyle and outlines the scope of the residential environment.

It also endeavours to summarise the main mechanistic pathways of various modifiable risk factors that cause thyroid cancer. Factors that prevent thyroid cancer include smoking and alcohol consumption, quality and regular sleep, consumption of cruciferous vegetables and dairy products, and consistent long-term exercise. Conversely, individuals with specific genetic mutations have an elevated risk of thyroid cancer from prolonged and frequent use of mobile phones. In addition, individuals who work in high-pressure jobs, work night shifts, and live near volcanoes or in environments associated with pesticides have an elevated risk of developing thyroid cancer.

The impact of living near a nuclear power plant on thyroid cancer remains inconclusive. Raising awareness of modifiable risk factors for thyroid cancer will help to accurately prevent and control thyroid cancer. It will provide a scientific basis for future research on lifestyles and living environments suitable for people at high risk of thyroid cancer.

Get Citation

Keywords

modifiable risk factors; thyroid cancer; lifestyle; residence environment

About this article
Title

Modifiable risk factors for thyroid cancer: lifestyle and residence environment

Journal

Endokrynologia Polska

Issue

Vol 75, No 2 (2024)

Article type

Review paper

Pages

119-129

Published online

2024-03-13

Page views

244

Article views/downloads

37

DOI

10.5603/ep.97258

Pubmed

38497372

Bibliographic record

Endokrynol Pol 2024;75(2):119-129.

Keywords

modifiable risk factors
thyroid cancer
lifestyle
residence environment

Authors

Yi Shen
Xian Wang
Lu Wang
Dandan Xiong
Cailian Wu
Liting Cen
Lianguang Xie
Xiangzhi Li

References (83)
  1. Bogović Crnčić T, Ilić Tomaš M, Girotto N, et al. Risk Factors for Thyroid Cancer: What Do We Know So Far? Acta Clin Croat. 2020; 59(Suppl 1): 66–72.
  2. Araque KA, Gubbi S, Klubo-Gwiezdzinska J. Updates on the Management of Thyroid Cancer. Horm Metab Res. 2020; 52(8): 562–577.
  3. Vaccarella S, Franceschi S, Bray F, et al. Worldwide Thyroid-Cancer Epidemic? The Increasing Impact of Overdiagnosis. N Engl J Med. 2016; 375(7): 614–617.
  4. La Vecchia C, Malvezzi M, Bosetti C, et al. Thyroid cancer mortality and incidence: a global overview. Int J Cancer. 2015; 136(9): 2187–2195.
  5. Azadnajafabad S, Saeedi Moghaddam S, Mohammadi E, et al. Global, regional, and national burden and quality of care index (QCI) of thyroid cancer: A systematic analysis of the Global Burden of Disease Study 1990-2017. Cancer Med. 2021; 10(7): 2496–2508.
  6. Aschebrook-Kilfoy B, Schechter RB, Shih YCT, et al. The clinical and economic burden of a sustained increase in thyroid cancer incidence. Cancer Epidemiol Biomarkers Prev. 2013; 22(7): 1252–1259.
  7. Malaguarnera R, Ledda C, Filippello A, et al. Thyroid Cancer and Circadian Clock Disruption. Cancers (Basel). 2020; 12(11).
  8. Babić Leko M, Gunjača I, Pleić N, et al. Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels. Int J Mol Sci. 2021; 22(12).
  9. Mogavero MP, DelRosso LM, Fanfulla F, et al. Sleep disorders and cancer: State of the art and future perspectives. Sleep Med Rev. 2021; 56: 101409.
  10. Fiore M, Cristaldi A, Okatyeva V, et al. Dietary habits and thyroid cancer risk: A hospital-based case-control study in Sicily (South Italy). Food Chem Toxicol. 2020; 146: 111778.
  11. Luo J, Li H, Deziel NC, et al. Genetic susceptibility may modify the association between cell phone use and thyroid cancer: A population-based case-control study in Connecticut. Environ Res. 2020; 182: 109013.
  12. Kim SoY, Yoo DM, Min C, et al. Association between Coffee Consumption/Physical Exercise and Gastric, Hepatic, Colon, Breast, Uterine Cervix, Lung, Thyroid, Prostate, and Bladder Cancer. Nutrients. 2021; 13(11).
  13. Demoury C, De Schutter H, Faes C, et al. Thyroid cancer incidence near nuclear sites in Belgium: An ecological study at small geographical level. Int J Cancer. 2020; 146(11): 3034–3043.
  14. Chen TY, Hsu CC, Feng IJ, et al. Higher risk for thyroid diseases in physicians than in the general population: a Taiwan nationwide population-based secondary analysis study. QJM. 2017; 110(3): 163–168.
  15. Wang M, Gong WW, Lu F, et al. Associations of intensity, duration, cumulative dose, and age at start of smoking, with thyroid cancer in Chinese males: A hospital-based case-control study in Zhejiang Province. Tob Induc Dis. 2020; 18: 97.
  16. An SY, Kim SoY, Oh DJ, et al. Obesity is positively related and tobacco smoking and alcohol consumption are negatively related to an increased risk of thyroid cancer. Sci Rep. 2020; 10(1): 19279.
  17. Myung SK, Lee CW, Lee J, et al. Risk Factors for Thyroid Cancer: A Hospital-Based Case-Control Study in Korean Adults. Cancer Res Treat. 2017; 49(1): 70–78.
  18. Lee JH, Chai YJ, Yi KaH. Effect of Cigarette Smoking on Thyroid Cancer: Meta-Analysis. Endocrinol Metab (Seoul). 2021; 36(3): 590–598.
  19. Yeo Y, Han K, Shin DW, et al. Changes in Smoking, Alcohol Consumption, and the Risk of Thyroid Cancer: A Population-Based Korean Cohort Study. Cancers (Basel). 2021; 13(10).
  20. Baron JA, Nichols HB, Anderson C, et al. Cigarette Smoking and Estrogen-Related Cancer. Cancer Epidemiol Biomarkers Prev. 2021; 30(8): 1462–1471.
  21. Afrashteh S, Fararouei M, Parad MT, et al. Sleep quality, stress and thyroid cancer: a case-control study. J Endocrinol Invest. 2022; 45(6): 1219–1226.
  22. Al-Habsi Z, Al-Noumani H, Al Hashmi I. Determinants of health-related quality of life among Omanis hospitalized patients with cancer: a cross-sectional study. Qual Life Res. 2022; 31(7): 2061–2070.
  23. Lou X, Wang H, Tu Y, et al. Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy. Sci Rep. 2021; 11(1): 13682.
  24. Nazem MR, Bastanhagh E, Emami A, et al. The relationship between thyroid function tests and sleep quality: cross-sectional study. Sleep Sci. 2021; 14(3): 196–200.
  25. Yan Y, Li J, Tang H, et al. Elevated thyroid-stimulating hormone levels are associated with poor sleep: a cross-sectional and longitudinal study. Endocrine. 2022; 75(1): 194–201.
  26. Polyzos SA, Kita M, Efstathiadou Z, et al. Serum thyrotropin concentration as a biochemical predictor of thyroid malignancy in patients presenting with thyroid nodules. J Cancer Res Clin Oncol. 2008; 134(9): 953–960.
  27. Tempaku PF, Mazzotti DR, Tufik S. Telomere length as a marker of sleep loss and sleep disturbances: a potential link between sleep and cellular senescence. Sleep Med. 2015; 16(5): 559–563.
  28. Huang L, Feng X, Yang W, et al. Appraising the Effect of Potential Risk Factors on Thyroid Cancer: A Mendelian Randomization Study. J Clin Endocrinol Metab. 2022; 107(7): e2783–e2791.
  29. Choi WJ, Kim J. Dietary factors and the risk of thyroid cancer: a review. Clin Nutr Res. 2014; 3(2): 75–88.
  30. Przybylik-Mazurek E, Hubalewska-Dydejczyk A, Kuźniarz-Rymarz S, et al. Dietary patterns as risk factors of differentiated thyroid carcinoma. Postepy Hig Med Dosw (Online). 2012; 66: 11–15.
  31. Jung SuK, Kim K, Tae K, et al. The effect of raw vegetable and fruit intake on thyroid cancer risk among women: a case-control study in South Korea. Br J Nutr. 2013; 109(1): 118–128.
  32. Han MiAh, Kim JH. Coffee Consumption and the Risk of Thyroid Cancer: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2017; 14(2).
  33. Yan AR, Zhang X, Shen H, et al. Urinary iodine is increased in papillary thyroid carcinoma but is not altered by regional population iodine intake status: a meta-analysis and implications. Endocr J. 2019; 66(6): 497–514.
  34. Knobel M, Medeiros-Neto G. Relevance of iodine intake as a reputed predisposing factor for thyroid cancer. Arq Bras Endocrinol Metabol. 2007; 51(5): 701–712.
  35. Aschebrook-Kilfoy B, Shu XO, Gao YT, et al. Thyroid cancer risk and dietary nitrate and nitrite intake in the Shanghai women's health study. Int J Cancer. 2013; 132(4): 897–904.
  36. Bahadoran Z, Mirmiran P, Ghasemi A, et al. Is dietary nitrate/nitrite exposure a risk factor for development of thyroid abnormality? A systematic review and meta-analysis. Nitric Oxide. 2015; 47: 65–76.
  37. Tadi K, Chang Y, Ashok BT, et al. 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease. Biochem Biophys Res Commun. 2005; 337(3): 1019–1025.
  38. Carlberg M, Hedendahl L, Ahonen M, et al. Increasing incidence of thyroid cancer in the Nordic countries with main focus on Swedish data. BMC Cancer. 2016; 16: 426.
  39. Lee M, Han M, Pak J. Analysis of Behavioral Characteristics of Smartphone Addiction Using Data Mining. Applied Sci. 2018; 8(7): 1191.
  40. Baan R, Grosse Y, Lauby-Secretan B, et al. WHO International Agency for Research on Cancer Monograph Working Group. Carcinogenicity of radiofrequency electromagnetic fields. Lancet Oncol. 2011; 12(7): 624–626.
  41. Carlberg M, Koppel T, Hedendahl LK, et al. Is the Increasing Incidence of Thyroid Cancer in the Nordic Countries Caused by Use of Mobile Phones? Int J Environ Res Public Health. 2020; 17(23).
  42. Iglesias ML, Schmidt A, Ghuzlan AAl, et al. Radiation exposure and thyroid cancer: a review. Arch Endocrinol Metab. 2017; 61(2): 180–187.
  43. Luo J, Deziel NC, Huang H, et al. Cell phone use and risk of thyroid cancer: a population-based case-control study in Connecticut. Ann Epidemiol. 2019; 29: 39–45.
  44. Havas M. When theory and observation collide: Can non-ionizing radiation cause cancer? Environ Pollut. 2017; 221: 501–505.
  45. Yakymenko I, Tsybulin O, Sidorik E, et al. Oxidative mechanisms of biological activity of low-intensity radiofrequency radiation. Electromagn Biol Med. 2016; 35(2): 186–202.
  46. Friedenreich CM, Ryder-Burbidge C, McNeil J. Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms. Mol Oncol. 2021; 15(3): 790–800.
  47. Bui AQ, Gunathilake M, Lee J, et al. Relationship Between Physical Activity Levels and Thyroid Cancer Risk: A Prospective Cohort Study in Korea. Thyroid. 2022; 32(11): 1402–1410.
  48. Fiore M, Cristaldi A, Okatyeva V, et al. Physical Activity and Thyroid Cancer Risk: A Case-Control Study in Catania (South Italy). Int J Environ Res Public Health. 2019; 16(8).
  49. Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst. 2000; 92(18): 1472–1489.
  50. Thomas RJ, Kenfield SA, Jimenez A. Exercise-induced biochemical changes and their potential influence on cancer: a scientific review. Br J Sports Med. 2017; 51(8): 640–644.
  51. Hong BS, Lee KPa. A systematic review of the biological mechanisms linking physical activity and breast cancer. Phys Act Nutr. 2020; 24(3): 25–31.
  52. Booth A, Magnuson A, Fouts J, et al. Adipose tissue, obesity and adipokines: role in cancer promotion. Horm Mol Biol Clin Investig. 2015; 21(1): 57–74.
  53. Chen KY, Yang CM, Lien CH, et al. Burnout, job satisfaction, and medical malpractice among physicians. Int J Med Sci. 2013; 10(11): 1471–1478.
  54. Rizza S, Neri A, Capanna A, et al. Night Shift Working Is Associated With an Increased Risk of Thyroid Nodules. J Occup Environ Med. 2020; 62(1): 1–3.
  55. Boelaert K, Horacek J, Holder RL, et al. Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration. J Clin Endocrinol Metab. 2006; 91(11): 4295–4301.
  56. Dai S, Mo Y, Wang Y, et al. Chronic Stress Promotes Cancer Development. Front Oncol. 2020; 10: 1492.
  57. Dianatinasab M, Fararouei M, Mohammadianpanah M, et al. Hair Coloring, Stress, and Smoking Increase the Risk of Breast Cancer: A Case-Control Study. Clin Breast Cancer. 2017; 17(8): 650–659.
  58. Li J, Zhang Bo, Bai Y, et al. Health-related quality of life analysis in differentiated thyroid carcinoma patients after thyroidectomy. Sci Rep. 2020; 10(1): 5765.
  59. Suzuki K, Mitsutake N, Saenko V, et al. Radiation signatures in childhood thyroid cancers after the Chernobyl accident: possible roles of radiation in carcinogenesis. Cancer Sci. 2015; 106(2): 127–133.
  60. Demoury C, De Smedt T, De Schutter H, et al. Thyroid Cancer Incidence around the Belgian Nuclear Sites, 2000-2014. Int J Environ Res Public Health. 2017; 14(9).
  61. Desbiolles A, Roudier C, Goria S, et al. Cancer incidence in adults living in the vicinity of nuclear power plants in France, based on data from the French Network of Cancer Registries. Int J Cancer. 2018; 142(5): 899–909.
  62. Kim J, Bang Y, Lee WJ. Living near nuclear power plants and thyroid cancer risk: A systematic review and meta-analysis. Environ Int. 2016; 87: 42–48.
  63. Malandrino P, Russo M, Gianì F, et al. Increased Thyroid Cancer Incidence in Volcanic Areas: A Role of Increased Heavy Metals in the Environment? Int J Mol Sci. 2020; 21(10).
  64. Russo M, Malandrino P, Addario WP, et al. Several Site-specific Cancers are Increased in the Volcanic Area in Sicily. Anticancer Res. 2015; 35(7): 3995–4001.
  65. Putri RG, Ysrafil Y, Awisarita W. Cancer Incidence in Volcanic Areas: A Systematic Review. Asian Pac J Cancer Prev. 2022; 23(6): 1817–1826.
  66. Kristbjornsdottir A, Rafnsson V. Incidence of cancer among residents of high temperature geothermal areas in Iceland: a census based study 1981 to 2010. Environ Health. 2012; 11: 73.
  67. Brasil VL, Ramos Pinto MB, Bonan RF, et al. Pesticides as risk factors for head and neck cancer: A review. J Oral Pathol Med. 2018; 47(7): 641–651.
  68. Grossman CM, Nussbaum RH, Nussbaum FD. Cancers among residents downwind of the Hanford, Washington, plutonium production site. Arch Environ Health. 2003; 58(5): 267–274.
  69. Omidakhsh N, Heck JE, Cockburn M, et al. Thyroid Cancer and Pesticide Use in a Central California Agricultural Area: A Case Control Study. J Clin Endocrinol Metab. 2022; 107(9): e3574–e3582.
  70. Garry VF, Holland SE, Erickson LL, et al. Male reproductive hormones and thyroid function in pesticide applicators in the Red River Valley of Minnesota. J Toxicol Environ Health A. 2003; 66(11): 965–986.
  71. Piccoli C, Cremonese C, Koifman RJ, et al. Pesticide exposure and thyroid function in an agricultural population in Brazil. Environ Res. 2016; 151: 389–398.
  72. Fiore E, Vitti P. Serum TSH and risk of papillary thyroid cancer in nodular thyroid disease. J Clin Endocrinol Metab. 2012; 97(4): 1134–1145.
  73. Gabora K, Bălăcescu O, Trifa A, et al. Thyroid carcinoma associated with other primary neoplasms, a single center study. Med Pharm Rep. 2022; 95(3): 275–281.
  74. Wei X, Wang X, Xiong J, et al. Risk and Prognostic Factors for BRAF Mutations in Papillary Thyroid Carcinoma. Biomed Res Int. 2022; 2022: 9959649.
  75. García-Jiménez C, Santisteban P. TSH signalling and cancer. Arq Bras Endocrinol Metabol. 2007; 51(5): 654–671.
  76. Chiamolera MI, Wondisford FE. Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism. Endocrinology. 2009; 150(3): 1091–1096.
  77. Vieira IH, Rodrigues D, Paiva I. The Mysterious Universe of the TSH Receptor. Front Endocrinol (Lausanne). 2022; 13: 944715.
  78. Chen GG, Vlantis AC, Zeng Q, et al. Regulation of cell growth by estrogen signaling and potential targets in thyroid cancer. Curr Cancer Drug Targets. 2008; 8(5): 367–377.
  79. Kochman J, Jakubczyk K, Bargiel P, et al. The Influence of Oxidative Stress on Thyroid Diseases. Antioxidants (Basel). 2021; 10(9).
  80. Taslipinar A, Bolu E, Kebapcilar L, et al. Insulin-like growth factor-1 is essential to the increased mortality caused by excess growth hormone: a case of thyroid cancer and non-Hodgkin's lymphoma in a patient with pituitary acromegaly. Med Oncol. 2009; 26(1): 62–66.
  81. Pidchenko N, Krasnoselskyi M, Mitriaieva N, et al. Insulin-like growth factors in the serum of patients with papillary thyroid cancer. Wiad Lek. 2021; 74(8): 1925–1930.
  82. Abdellateif MS, Shaarawy S, Elesawy YF, et al. The Role of Vitamin D, Platelet-Derived Growth Factor and Insulin-Like Growth Factor 1 in the Progression of Thyroid Diseases. Asian Pac J Cancer Prev. 2020; 21(7): 2083–2089.
  83. Yang Li, Tan Z, Li Y, et al. Insulin-like growth factor 1 promotes proliferation and invasion of papillary thyroid cancer through the STAT3 pathway. J Clin Lab Anal. 2020; 34(12): e23531.

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