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Original paper
Published online: 2021-02-02
Submitted: 2020-11-09
Accepted: 2021-01-21
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A cross-sectional comparison of selected anthropometric, laboratory and densitometric parameters in postmenopausal osteoporotic women with and without vertebral compression fractures.

Piotr Sawicki, Marek Tałałaj, Katarzyna Życińska, Wojciech Stefan Zgliczyński, Waldemar Wierzba
DOI: 10.5603/EP.a2021.0011
·
Pubmed: 33619710

open access

Ahead of print
Original Paper
Published online: 2021-02-02
Submitted: 2020-11-09
Accepted: 2021-01-21

Abstract

Introduction: Osteoporosis leads to an increased risk of vertebral compression fractures (VCFs). Most of them are spontaneous, which makes early diagnosis difficult. The aim of the study was to find parameters that distinguish osteoporotic women with and without vertebral compression fractures. Material and methods: 437 women with postmenopausal osteoporosis were enrolled to the study. Based on the results of densitometric vertebral fracture assessment patients were divided into two groups: with (n=193) and without (n=244) VCFs. Then selected anthropometric, laboratory and densitometric parameters as well as questionnaire data were compared. Results: The following distinguishing factors were found among patients with VCFs in comparison to patients without such fractures: older age – 73.93 years vs. 69.63 years [p(1)<0.001, p(2) <0.001], shorter height –1.56 m vs. 1.58 m [p(4)<0.001], lower value of glomerular filtration rate (GFR) according to Cockcroft – Gault formula – 58.22 ml/min. vs. 66.25 ml/min. [p(1)<0.025, p(2)=0.002], lower peripheral blood hemoglobin and serum albumin concentration (OR=1.24, 95% CI: 1.02-1.51, p(5)=0.03; OR=2.29, 95% CI: 1.09-4.80, p(5)=0.03, respectively), higher 10-year risk of major osteoporotic fracture (FRAX MOF) –12.01% vs. 9.69% [p(1)<0.01, p(2)<0.001] and hip fracture (FRAX HIP) –3.85% vs. 2.55% [p(1)<0.01, p(2)<0.001]. In addition, among patients with VCFs a greater severity of back pain was found in the 11-grade scale of pain intensity – 6.12 vs. 4.29 [p(1)<0.001, p(2)<0.001, p(3)<0.001]. The bone mineral content (BMC) and bone mineral density (BMD) of hip were lower in patients with VCFs – 25.25 g vs. 26.2 g and 0.72 g/cm2 vs. 0.75 g/cm2, respectively [p(4)=0.04 and p(4)<0.001, respectively]. Conclusions: Patients with VCFs were characterized by greater back pain intensity, higher fractures risk according to FRAX calculator and lower values of: GFR according to Cockcroft-Gault formula, peripheral blood hemoglobin and serum albumin concentration as well as BMD of hip. Further studies are required to validate the FRAX calculator to assess not only the risk of future fractures but also unrecognized VCFs.

Abstract

Introduction: Osteoporosis leads to an increased risk of vertebral compression fractures (VCFs). Most of them are spontaneous, which makes early diagnosis difficult. The aim of the study was to find parameters that distinguish osteoporotic women with and without vertebral compression fractures. Material and methods: 437 women with postmenopausal osteoporosis were enrolled to the study. Based on the results of densitometric vertebral fracture assessment patients were divided into two groups: with (n=193) and without (n=244) VCFs. Then selected anthropometric, laboratory and densitometric parameters as well as questionnaire data were compared. Results: The following distinguishing factors were found among patients with VCFs in comparison to patients without such fractures: older age – 73.93 years vs. 69.63 years [p(1)<0.001, p(2) <0.001], shorter height –1.56 m vs. 1.58 m [p(4)<0.001], lower value of glomerular filtration rate (GFR) according to Cockcroft – Gault formula – 58.22 ml/min. vs. 66.25 ml/min. [p(1)<0.025, p(2)=0.002], lower peripheral blood hemoglobin and serum albumin concentration (OR=1.24, 95% CI: 1.02-1.51, p(5)=0.03; OR=2.29, 95% CI: 1.09-4.80, p(5)=0.03, respectively), higher 10-year risk of major osteoporotic fracture (FRAX MOF) –12.01% vs. 9.69% [p(1)<0.01, p(2)<0.001] and hip fracture (FRAX HIP) –3.85% vs. 2.55% [p(1)<0.01, p(2)<0.001]. In addition, among patients with VCFs a greater severity of back pain was found in the 11-grade scale of pain intensity – 6.12 vs. 4.29 [p(1)<0.001, p(2)<0.001, p(3)<0.001]. The bone mineral content (BMC) and bone mineral density (BMD) of hip were lower in patients with VCFs – 25.25 g vs. 26.2 g and 0.72 g/cm2 vs. 0.75 g/cm2, respectively [p(4)=0.04 and p(4)<0.001, respectively]. Conclusions: Patients with VCFs were characterized by greater back pain intensity, higher fractures risk according to FRAX calculator and lower values of: GFR according to Cockcroft-Gault formula, peripheral blood hemoglobin and serum albumin concentration as well as BMD of hip. Further studies are required to validate the FRAX calculator to assess not only the risk of future fractures but also unrecognized VCFs.
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Keywords

osteoporosis; spinal fractures; back pain; cross-sectional studies

About this article
Title

A cross-sectional comparison of selected anthropometric, laboratory and densitometric parameters in postmenopausal osteoporotic women with and without vertebral compression fractures.

Journal

Endokrynologia Polska

Issue

Ahead of print

Article type

Original paper

Published online

2021-02-02

DOI

10.5603/EP.a2021.0011

Pubmed

33619710

Keywords

osteoporosis
spinal fractures
back pain
cross-sectional studies

Authors

Piotr Sawicki
Marek Tałałaj
Katarzyna Życińska
Wojciech Stefan Zgliczyński
Waldemar Wierzba

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