open access

Vol 71, No 6 (2020)
Original paper
Published online: 2020-09-16
Submitted: 2020-06-08
Accepted: 2020-07-15
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Bone densitometry by radiofrequency echographic multi-spectrometry (REMS) in acromegaly patients

Małgorzata Rolla, Jowita Halupczok-Żyła, Aleksandra Jawiarczyk-Przybyłowska, Marek Bolanowski
DOI: 10.5603/EP.a2020.0056
·
Pubmed: 32944924
·
Endokrynologia Polska 2020;71(6):524-531.

open access

Vol 71, No 6 (2020)
Original Paper
Published online: 2020-09-16
Submitted: 2020-06-08
Accepted: 2020-07-15

Abstract

Introduction: Radiofrequency echographic multi-spectrometry (REMS) is a recently introduced non-ionising technology employed in the evaluation of osteoporosis. The aim of our study was to compare bone mineral density (BMD) in acromegaly patients and healthy controls by performing novel REMS densitometry. The second objective was to analyse the correlation between results of REMS and classical dual-energy X-ray absorptiometry (DXA) in acromegaly patients.

Material and methods: We enrolled 33 patients with acromegaly (AG) and 24 controls (CG). The acromegaly patients were divided into two subgroups: well-controlled acromegaly (WCA) and surgery-cured acromegaly (SCA). REMS was performed in all participants, while DXA was performed only in the acromegaly group. IGF-I and GH levels were measured in acromegaly patients.

Results: Bone mineral density of the lumbar spine (LS) and the femoral neck (FN) obtained from REMS did not reveal significant differences between AG, CG, WCA, and SCA. Similarly, there were no significant differences in BMD measured by DXA at the LS and at the FN between WCA and SCA. Significant positive correlations between IGF-I concentrations and BMD obtained from both REMS and DXA were detected in the AG and WCA. In the AG and WCA, there were positive correlations between T-scores and LS BMD obtained from both methods.

Conclusions: Radiofrequency echographic multi-spectrometry is a potential method in assessment of bone status in acromegaly. Further studies with participation of active disease patients are needed. 

Abstract

Introduction: Radiofrequency echographic multi-spectrometry (REMS) is a recently introduced non-ionising technology employed in the evaluation of osteoporosis. The aim of our study was to compare bone mineral density (BMD) in acromegaly patients and healthy controls by performing novel REMS densitometry. The second objective was to analyse the correlation between results of REMS and classical dual-energy X-ray absorptiometry (DXA) in acromegaly patients.

Material and methods: We enrolled 33 patients with acromegaly (AG) and 24 controls (CG). The acromegaly patients were divided into two subgroups: well-controlled acromegaly (WCA) and surgery-cured acromegaly (SCA). REMS was performed in all participants, while DXA was performed only in the acromegaly group. IGF-I and GH levels were measured in acromegaly patients.

Results: Bone mineral density of the lumbar spine (LS) and the femoral neck (FN) obtained from REMS did not reveal significant differences between AG, CG, WCA, and SCA. Similarly, there were no significant differences in BMD measured by DXA at the LS and at the FN between WCA and SCA. Significant positive correlations between IGF-I concentrations and BMD obtained from both REMS and DXA were detected in the AG and WCA. In the AG and WCA, there were positive correlations between T-scores and LS BMD obtained from both methods.

Conclusions: Radiofrequency echographic multi-spectrometry is a potential method in assessment of bone status in acromegaly. Further studies with participation of active disease patients are needed. 

Get Citation

Keywords

acromegaly; REMS; DXA; osteoporosis; densitometry

About this article
Title

Bone densitometry by radiofrequency echographic multi-spectrometry (REMS) in acromegaly patients

Journal

Endokrynologia Polska

Issue

Vol 71, No 6 (2020)

Article type

Original paper

Pages

524-531

Published online

2020-09-16

DOI

10.5603/EP.a2020.0056

Pubmed

32944924

Bibliographic record

Endokrynologia Polska 2020;71(6):524-531.

Keywords

acromegaly
REMS
DXA
osteoporosis
densitometry

Authors

Małgorzata Rolla
Jowita Halupczok-Żyła
Aleksandra Jawiarczyk-Przybyłowska
Marek Bolanowski

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