open access

Vol 59, No 6 (2008)
Postgraduate education
Published online: 2008-10-30
Submitted: 2013-02-15
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Central precocious puberty

Robert Krysiak, Bogdan Marek, Bogusław Okopień
Endokrynologia Polska 2008;59(6):530-540.

open access

Vol 59, No 6 (2008)
Postgraduate education
Published online: 2008-10-30
Submitted: 2013-02-15

Abstract

Central precocious puberty, defined as the onset of puberty before the age 8 years in girls and 9 years in boys, results from a premature activation of gonadotropin-releasing hormone neurons in the hypothalamus. This condition is characterised by early pubertal changes, acceleration of growth velocity, and rapid bone maturation that often result in reduced adult height. It may be either idiopathic or associated with hypothalamic hamartoma, brain neoplasms, numerous non-cancerous disorders of the central nervous system and treatment of peripheral precocious puberty. The goal of the initial assessment of children is to exclude the presence of all these organic disorders. The diagnosis should include detailed anamnesis and clinical examination, measurement of pituitary and sex hormones, assessment of bone age, and imaging of the hypothalamus, pituitary gland, abdomen, pelvis and gonads. The treatment of choice are gonadotropin-releasing hormone agonists. In this paper, we review the current views on the etiopathogenesis, clinical presentation, diagnosis and management of central precocious puberty.

Abstract

Central precocious puberty, defined as the onset of puberty before the age 8 years in girls and 9 years in boys, results from a premature activation of gonadotropin-releasing hormone neurons in the hypothalamus. This condition is characterised by early pubertal changes, acceleration of growth velocity, and rapid bone maturation that often result in reduced adult height. It may be either idiopathic or associated with hypothalamic hamartoma, brain neoplasms, numerous non-cancerous disorders of the central nervous system and treatment of peripheral precocious puberty. The goal of the initial assessment of children is to exclude the presence of all these organic disorders. The diagnosis should include detailed anamnesis and clinical examination, measurement of pituitary and sex hormones, assessment of bone age, and imaging of the hypothalamus, pituitary gland, abdomen, pelvis and gonads. The treatment of choice are gonadotropin-releasing hormone agonists. In this paper, we review the current views on the etiopathogenesis, clinical presentation, diagnosis and management of central precocious puberty.
Get Citation

Keywords

central precocious puberty; etiopathogenesis; clinical manifestation; diagnosis; treatment

About this article
Title

Central precocious puberty

Journal

Endokrynologia Polska

Issue

Vol 59, No 6 (2008)

Pages

530-540

Published online

2008-10-30

Bibliographic record

Endokrynologia Polska 2008;59(6):530-540.

Keywords

central precocious puberty
etiopathogenesis
clinical manifestation
diagnosis
treatment

Authors

Robert Krysiak
Bogdan Marek
Bogusław Okopień

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