Vol 7, No 4 (2018)
Review article
Published online: 2018-09-11
Association of pentraxin 3 with atherosclerotic cardiovascular diseases — general knowledge in 2018
DOI: 10.5603/DK.2018.0015
Clin Diabetol 2018;7(4):203-206.
Abstract
Pentraxin 3 (PTX3), an acute phase protein, contrary to C-reactive protein (CRP), is produced locally, where the inflammation takes place, for example in the endothelium. It is not clearly known whether the inflammatory
factors are the cause of atherosclerosis or only indicators of vascular inflammation. It is still not known what is the role of PTX in the natural history of atherosclerosis — protection or promotion. It was established that the elevated plasma concentration of PTX is related to the occurrence of cardiovascular
events caused by atherosclerosis, including myocardial infarction (MI), decreased 3-months survival after MI, unstable angina or heart failure. On the other hand, PTX is suspected to play a protective role in the ischemic cardiac muscle. Therefore, if confirmed in trials, PTX3 could be administered during acute coronary syndrome. PTX3 might in the future become useful in assessing prognosis for patients with cardiovascular diseases and choosing the best therapeutic option for them.
Keywords: pentraxinatherosclerosiscardiovascular diseases
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