open access

Vol 2, No 4 (2001): Practical Diabetology
Original articles (translated)
Published online: 2001-11-19
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Detection of hypoglycemia with the GlucoWatch biographer

Kenneth R. Pitzer, Shashi Desai, Tim Dunn, Steve EdelmanYalia Jayalakshmi, John Kennedy, Janet A. Tamada, Russell O. Potts
Diabetologia Praktyczna 2001;2(4):307-314.

open access

Vol 2, No 4 (2001): Practical Diabetology
Original articles (translated)
Published online: 2001-11-19

Abstract

INTRODUCTION. Hypoglycemia is a common acute complication of diabetes therapy. The GlucoWatch biographer provides frequent and automatic glucose measurements with an adjustable low-glucose alarm. We have analyzed the performance of the biographer low-glucose alarm relative to hypoglycemia as defined by blood glucose £ 3.9 mmol/l.
MATERIAL AND METHODS. The analysis was based on 1,091 biographer uses from four clinical trials, which generated 14,487 paired (biographer and blood glucose) readings.
RESULTS. The results show that as the low-glucose alert level of the biographer is increased, the number of true positive alerts (alarm sounds and blood glucose £ 3.9 mmol/l) and false positive alerts (alarm sounds but blood glucose > 3.9 mmol/l) increased. When analyzed as a function of varying low-glucose alert levels, the results show receiver operator characteristic curves consistent with a highly useful diagnostic tool. Setting the alert level from 1.1 to 1.7 mmol/l above the level of concern is likely to optimize the trade-off between true positives and false positives for each user. When the same blood glucose data are analyzed for typical monitoring practices (two or four measurements per day), the results show that fewer hypoglycemic events are detected than those detected with the biographer.
CONCLUSIONS. The frequent and automatic nature of the biographer readings allows more effective detection of hypoglycemia than that achieved with current medical practice.

Abstract

INTRODUCTION. Hypoglycemia is a common acute complication of diabetes therapy. The GlucoWatch biographer provides frequent and automatic glucose measurements with an adjustable low-glucose alarm. We have analyzed the performance of the biographer low-glucose alarm relative to hypoglycemia as defined by blood glucose £ 3.9 mmol/l.
MATERIAL AND METHODS. The analysis was based on 1,091 biographer uses from four clinical trials, which generated 14,487 paired (biographer and blood glucose) readings.
RESULTS. The results show that as the low-glucose alert level of the biographer is increased, the number of true positive alerts (alarm sounds and blood glucose £ 3.9 mmol/l) and false positive alerts (alarm sounds but blood glucose > 3.9 mmol/l) increased. When analyzed as a function of varying low-glucose alert levels, the results show receiver operator characteristic curves consistent with a highly useful diagnostic tool. Setting the alert level from 1.1 to 1.7 mmol/l above the level of concern is likely to optimize the trade-off between true positives and false positives for each user. When the same blood glucose data are analyzed for typical monitoring practices (two or four measurements per day), the results show that fewer hypoglycemic events are detected than those detected with the biographer.
CONCLUSIONS. The frequent and automatic nature of the biographer readings allows more effective detection of hypoglycemia than that achieved with current medical practice.
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Keywords

hypoglycemia; glycemia measurements; biographer; ionophoresis

About this article
Title

Detection of hypoglycemia with the GlucoWatch biographer

Journal

Clinical Diabetology

Issue

Vol 2, No 4 (2001): Practical Diabetology

Pages

307-314

Published online

2001-11-19

Bibliographic record

Diabetologia Praktyczna 2001;2(4):307-314.

Keywords

hypoglycemia
glycemia measurements
biographer
ionophoresis

Authors

Kenneth R. Pitzer
Shashi Desai
Tim Dunn
Steve EdelmanYalia Jayalakshmi
John Kennedy
Janet A. Tamada
Russell O. Potts

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