open access

Vol 4, No 2 (2003): Practical Diabetology
Original articles (submitted)
Published online: 2003-04-28
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The role of individual criteria in the assessment of metabolic syndrome control in the DINAMIC study (IV)

Teresa Kasperska-Czyżyk, Władysław Grzeszczak, Jacek Sieradzki, Marcin Szczepański oraz Zespół Badaczy DINAMIC
Diabetologia Praktyczna 2003;4(2):125-132.

open access

Vol 4, No 2 (2003): Practical Diabetology
Original articles (submitted)
Published online: 2003-04-28

Abstract

The present study was undertaken in 975 patients with type 2 diabetes mellitus to measure eight anthropometric (clinical) and laboratory parameters defining the metabolic syndrome and to identify their role in the pathogenesis of this syndrome. In multifactorial analysis the number of measurable variables was reduced to three main factors (components), of which the first and third ones were most strongly correlated with lipid disorders, the second with arterial hypertension and body mass index (BMI), yielding the cumulative variance of 60%. The level of HbA1c, a marker of glucose normal and altered metabolism, appeared to be the weakest correlate. These findings lead to a very important conclusion — also for family physicians — that in the treatment of type 2 diabetes mellitus it is necessary to take into account the independent effects of lipid disorders, hypertension and obesity, whereas in patients with the latter two disorders only, the concomitant presence of glucose intolerance, basing upon more dynamic measurements of glycemia in the fasting state, after meals or during OGTT.

Abstract

The present study was undertaken in 975 patients with type 2 diabetes mellitus to measure eight anthropometric (clinical) and laboratory parameters defining the metabolic syndrome and to identify their role in the pathogenesis of this syndrome. In multifactorial analysis the number of measurable variables was reduced to three main factors (components), of which the first and third ones were most strongly correlated with lipid disorders, the second with arterial hypertension and body mass index (BMI), yielding the cumulative variance of 60%. The level of HbA1c, a marker of glucose normal and altered metabolism, appeared to be the weakest correlate. These findings lead to a very important conclusion — also for family physicians — that in the treatment of type 2 diabetes mellitus it is necessary to take into account the independent effects of lipid disorders, hypertension and obesity, whereas in patients with the latter two disorders only, the concomitant presence of glucose intolerance, basing upon more dynamic measurements of glycemia in the fasting state, after meals or during OGTT.
Get Citation

Keywords

metabolic syndrome; dyslipidemia; glycated hemoglobin; body mass index; arterial pressure; factor analysis

About this article
Title

The role of individual criteria in the assessment of metabolic syndrome control in the DINAMIC study (IV)

Journal

Clinical Diabetology

Issue

Vol 4, No 2 (2003): Practical Diabetology

Pages

125-132

Published online

2003-04-28

Bibliographic record

Diabetologia Praktyczna 2003;4(2):125-132.

Keywords

metabolic syndrome
dyslipidemia
glycated hemoglobin
body mass index
arterial pressure
factor analysis

Authors

Teresa Kasperska-Czyżyk
Władysław Grzeszczak
Jacek Sieradzki
Marcin Szczepański oraz Zespół Badaczy DINAMIC

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