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Vol 25, No 5 (2018)
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Published online: 2018-10-30

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Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk

Claudio Borghi, Andrzej Tykarski, Krystyna Widecka, Krzysztof J. Filipiak, Justyna Domienik-Karłowicz, Katarzyna Kostka-Jeziorny, Albert Varga, Milosz Jaguszewski, Krzysztof Narkiewicz, Giuseppe Mancia
DOI: 10.5603/CJ.2018.0116
Pubmed: 30394510
Cardiol J 2018;25(5):545-564.

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References

  1. Kuo CF, Grainge MJ, Zhang W, et al. Global epidemiology of gout: prevalence, incidence and risk factors. Nat Rev Rheumatol. 2015; 11(11): 649–662.
    CrossRefPubMed
  2. Zhu Y, Pandya BJ, Choi HK. Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007-2008. Am J Med. 2012; 125(7): 679–687.e1.
    CrossRefPubMed
  3. Bardin T, Richette P. Impact of comorbidities on gout and hyperuricaemia: an update on prevalence and treatment options. BMC Med. 2017; 15(1): 123.
    CrossRefPubMed
  4. Borghi C, Rosei EA, Bardin T, et al. Serum uric acid and the risk of cardiovascular and renal disease. J Hypertens. 2015; 33(9): 1729–1741.
    CrossRefPubMed
  5. Conen D, Wietlisbach V, Bovet P, et al. Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country. BMC Public Health. 2004; 4: 9.
    CrossRefPubMed
  6. Qiu L, Cheng Xq, Wu J, et al. Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces. BMC Public Health. 2013; 13: 664.
    CrossRefPubMed
  7. Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. N Engl J Med. 2008; 359(17): 1811–1821.
    CrossRefPubMed
  8. Johnson RJ, Titte S, Cade JR, et al. Uric acid, evolution and primitive cultures. Semin Nephrol. 2005; 25(1): 3–8.
    PubMed
  9. Struthers A, Shearer F. Allopurinol: novel indications in cardiovascular disease. Heart. 2012; 98(21): 1543–1545.
    CrossRefPubMed
  10. Ragab G, Elshahaly M, Bardin T. Gout: An old disease in new perspective: a review. J Adv Res. 2017; 8(5): 495–511.
    CrossRefPubMed
  11. Perez-Ruiz F, Calabozo M, Pijoan JI, et al. Effect of urate-lowering therapy on the velocity of size reduction of tophi in chronic gout. Arthritis Rheum. 2002; 47(4): 356–360.
    CrossRefPubMed
  12. McCarty DJ. A historical note: Leeuwenhoek's description of crystals from a gouty tophus. Arthritis Rheum. 1970; 13(4): 414–418.
    PubMed
  13. Lin KC, Lin HY, Chou P. The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. J Rheumatol. 2000; 27(6): 1501–1505.
  14. Hall AP, Barry PE, Dawber TR, et al. Epidemiology of gout and hyperuricemia. A long-term population study. Am J Med. 1967; 42(1): 27–37.
    PubMed
  15. Schlesinger N, Norquist JM, Watson DJ. Serum urate during acute gout. J Rheumatol. 2009; 36(6): 1287–1289.
    CrossRefPubMed
  16. Logan JA, Morrison E, McGill PE. Serum uric acid in acute gout. Ann Rheum Dis. 1997; 56(11): 696–697.
    PubMed
  17. Forbess LJ, Fields TR. The broad spectrum of urate crystal deposition: unusual presentations of gouty tophi. Semin Arthritis Rheum. 2012; 42(2): 146–154.
    CrossRefPubMed
  18. Martillo MA, Nazzal L, Crittenden DB. The crystallization of monosodium urate. Curr Rheumatol Rep. 2014; 16(2): 400.
    CrossRefPubMed
  19. Nakagawa T, Hu H, Zharikov S, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol. 2006; 290(3): F625–F631.
    CrossRefPubMed
  20. Enomoto A, Kimura H, Chairoungdua A, et al. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature. 2002; 417(6887): 447–452.
    CrossRefPubMed
  21. Borghi C. The management of hyperuricemia: back to the pathophysiology of uric acid. Curr Med Res Opin. 2017; 33(sup3): 1–4.
    CrossRefPubMed
  22. de Oliveira EP, Burini RC. High plasma uric acid concentration: causes and consequences. Diabetol Metab Syndr. 2012; 4: 12.
    CrossRefPubMed
  23. Prasad M, Matteson EL, Herrmann J, et al. Uric acid is associated with inflammation, coronary microvascular dysfunction, and adverse outcomes in postmenopausal women. Hypertension. 2017; 69(2): 236–242.
    CrossRefPubMed
  24. Farquharson CA, et al. Allopurinol improves endothelial dysfunction in chronic heart failure. Circulation. 2002; 106(2): 221–226.
  25. Watanabe S, Kang DH, Feng L, et al. Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension. 2002; 40(3): 355–360.
    PubMed
  26. Lin C, Zhang Pu, Xue Y, et al. Link of renal microcirculatory dysfunction to increased coronary microcirculatory resistance in hypertensive patients. Cardiol J. 2017; 24(6): 623–632.
    CrossRefPubMed
  27. Mazzali M, Hughes J, Kim YG, et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension. 2001; 38(5): 1101–1106.
    PubMed
  28. Kang DH, Park SK, Lee IK, et al. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol. 2005; 16(12): 3553–3562.
    CrossRefPubMed
  29. Corry DB, Eslami P, Yamamoto K, et al. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. J Hypertens. 2008; 26(2): 269–275.
    CrossRefPubMed
  30. Kang DH, Han L, Ouyang X, et al. Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter. Am J Nephrol. 2005; 25(5): 425–433.
    CrossRefPubMed
  31. Feig DI, Nakagawa T, Karumanchi SA, et al. Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int. 2004; 66(1): 281–287.
    CrossRefPubMed
  32. Lee JE, Kim YG, Choi YH, et al. Serum uric acid is associated with microalbuminuria in prehypertension. Hypertension. 2006; 47(5): 962–967.
    CrossRefPubMed
  33. Iseki K, Oshiro S, Tozawa M, et al. Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects. Hypertens Res. 2001; 24(6): 691–697.
    PubMed
  34. Rosolowsky ET, Ficociello LH, Maselli NJ, et al. High-normal serum uric acid is associated with impaired glomerular filtration rate in nonproteinuric patients with type 1 diabetes. Clin J Am Soc Nephrol. 2008; 3(3): 706–713.
    CrossRefPubMed
  35. Furukawa S, Fujita T, Shimabukuro M, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004; 114(12): 1752–1761.
    CrossRefPubMed
  36. Fabbrini E, Serafini M, Baric IC, et al. Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes. 2014; 63(3): 976–981.
    CrossRef
  37. Grassi D, Desideri G, Giacomantonio ADi, et al. Hyperuricemia and cardiovascular risk. High Blood Press Cardiovasc Prev. 2014; 21(4): 235–242.
    CrossRef
  38. Reginato AM, Mount DB, Yang I, et al. The genetics of hyperuricaemia and gout. Nat Rev Rheumatol. 2012; 8(10): 610–621.
    CrossRefPubMed
  39. Kalousdian S, Fabsitz R, Havlik R, et al. Heritability of clinical chemistries in an older twin cohort: the NHLBI Twin Study. Genet Epidemiol. 1987; 4(1): 1–11.
    CrossRefPubMed
  40. Ichida K, Matsuo H, Takada T, et al. Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat Commun. 2012; 3: 764.
    CrossRefPubMed
  41. Kleber ME, Delgado G, Grammer TB, et al. Uric acid and cardiovascular events: a mendelian randomization study. J Am Soc Nephrol. 2015; 26(11): 2831–2838.
    CrossRefPubMed
  42. Hughes K, Flynn T, de Zoysa J, et al. Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function. Kidney Int. 2014; 85(2): 344–351.
    CrossRefPubMed
  43. Mallamaci F, Testa A, Leonardis D, et al. A polymorphism in the major gene regulating serum uric acid associates with clinic SBP and the white-coat effect in a family-based study. J Hypertens. 2014; 32(8): 1621–1628.
    CrossRefPubMed
  44. Parsa A, Brown E, Weir MR, et al. Genotype-based changes in serum uric acid affect blood pressure. Kidney Int. 2012; 81(5): 502–507.
    CrossRefPubMed
  45. Major TJ, Dalbeth N, Stahl EA, et al. An update on the genetics of hyperuricaemia and gout. Nat Rev Rheumatol. 2018; 14(6): 341–353.
    CrossRefPubMed
  46. Cannon PJ, Stason WB, Demartini FE, et al. Hyperuricemia in primary and renal hypertension. N Engl J Med. 1966; 275(9): 457–464.
    CrossRefPubMed
  47. Ford ES, Li C, Cook S, et al. Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation. 2007; 115(19): 2526–2532.
    CrossRefPubMed
  48. Puig JG, Martínez MA. Hyperuricemia, gout and the metabolic syndrome. Curr Opin Rheumatol. 2008; 20(2): 187–191.
    CrossRefPubMed
  49. Tuttle KR, Short RA, Johnson RJ. Sex differences in uric acid and risk factors for coronary artery disease. Am J Cardiol. 2001; 87(12): 1411–1414.
    PubMed
  50. Dehghan A, van Hoek M, Sijbrands EJG, et al. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care. 2008; 31(2): 361–362.
    CrossRefPubMed
  51. Schretlen DJ, Inscore AB, Vannorsdall TD, et al. Serum uric acid and brain ischemia in normal elderly adults. Neurology. 2007; 69(14): 1418–1423.
    CrossRefPubMed
  52. Lehto S, Niskanen L, Rönnemaa T, et al. Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus. Stroke. 1998; 29(3): 635–639.
    PubMed
  53. Yu KH, Kuo CF, Luo SF, et al. Risk of end-stage renal disease associated with gout: a nationwide population study. Arthritis Res Ther. 2012; 14(2): R83.
    CrossRefPubMed
  54. Abbott RD, Brand FN, Kannel WB, et al. Gout and coronary heart disease: the Framingham Study. J Clin Epidemiol. 1988; 41(3): 237–242.
    PubMed
  55. De Vera MA, Rahman MM, Bhole V, et al. Independent impact of gout on the risk of acute myocardial infarction among elderly women: a population-based study. Ann Rheum Dis. 2010; 69(6): 1162–1164.
    CrossRefPubMed
  56. Choi HK, Mount DB, Reginato AM. Pathogenesis of gout. Ann Intern Med. 2005; 143(7): 499–516.
    PubMed
  57. Feig DI, Johnson RJ. Hyperuricemia in childhood primary hypertension. Hypertension. 2003; 42(3): 247–252.
    CrossRefPubMed
  58. Nakagawa T, Tuttle KR, Short RA, et al. Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nat Clin Pract Nephrol. 2005; 1(2): 80–86.
    CrossRefPubMed
  59. Niskanen LK, Laaksonen DE, Nyyssönen K, et al. Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study. Arch Intern Med. 2004; 164(14): 1546–1551.
    CrossRefPubMed
  60. Yan D, Wang J, Jiang F, et al. A causal relationship between uric acid and diabetic macrovascular disease in Chinese type 2 diabetes patients: A Mendelian randomization analysis. Int J Cardiol. 2016; 214: 194–199.
    CrossRefPubMed
  61. Kuwabara M, Borghi C, Cicero AFG, et al. Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan. Int J Cardiol. 2018; 261: 183–188.
    CrossRefPubMed
  62. Borghi C, Desideri G. Urate-Lowering drugs and prevention of cardiovascular disease: the emerging role of xanthine oxidase inhibition. Hypertension. 2016; 67(3): 496–498.
    CrossRefPubMed
  63. Bove M, Cicero AF, Veronesi M, et al. An evidence-based review on urate-lowering treatments: implications for optimal treatment of chronic hyperuricemia. Vasc Health Risk Manag. 2017; 13: 23–28.
    CrossRefPubMed
  64. Lurbe E, Torro MI, Alvarez-Pitti J, et al. Uric acid is linked to cardiometabolic risk factors in overweight and obese youths. J Hypertens. 2018; 36(9): 1840–1846.
    CrossRefPubMed
  65. Jalal DI, Chonchol M, Chen W, et al. Uric acid as a target of therapy in CKD. Am J Kidney Dis. 2013; 61(1): 134–146.
    CrossRefPubMed
  66. Shadick NA, Kim R, Weiss S, et al. Effect of low level lead exposure on hyperuricemia and gout among middle aged and elderly men: the normative aging study. J Rheumatol. 2000; 27(7): 1708–1712.
    PubMed
  67. Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 2011; 63(10): 3136–3141.
    CrossRefPubMed
  68. Yü TF, Berger L, Dorph DJ, et al. Renal function in gout. V. Factors influencing the renal hemodynamics. Am J Med. 1979; 67(5): 766–771.
    PubMed
  69. Tykarski A. Evaluation of renal handling of uric acid in essential hypertension: hyperuricemia related to decreased urate secretion. Nephron. 1991; 59(3): 364–368.
    CrossRefPubMed
  70. Messerli FH, Frohlich ED, Dreslinski GR, et al. Serum uric acid in essential hypertension: an indicator of renal vascular involvement. Ann Intern Med. 1980; 93(6): 817–821.
    PubMed
  71. Alper AB, Chen W, Yau L, et al. Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study. Hypertension. 2005; 45(1): 34–38.
    CrossRefPubMed
  72. Dyer AR, Liu K, Walsh M, et al. Ten-year incidence of elevated blood pressure and its predictors: the CARDIA study. Coronary Artery Risk Development in (Young) Adults. J Hum Hypertens. 1999; 13(1): 13–21.
    PubMed
  73. Forman JP, Choi H, Curhan GC. Plasma uric acid level and risk for incident hypertension among men. J Am Soc Nephrol. 2007; 18(1): 287–292.
    CrossRefPubMed
  74. Hunt SC, Stephenson SH, Hopkins PN, et al. Predictors of an increased risk of future hypertension in Utah. A screening analysis. Hypertension. 1991; 17(6_pt_2): 969–976.
    CrossRef
  75. Imazu M, Yamamoto H, Toyofuku M, et al. Hyperinsulinemia for the development of hypertension: data from the Hawaii-Los Angeles-Hiroshima Study. Hypertens Res. 2001; 24(5): 531–536.
    PubMed
  76. Jossa F, Farinaro E, Panico S, et al. Serum uric acid and hypertension: the Olivetti heart study. J Hum Hypertens. 1994; 8(9): 677–681.
    PubMed
  77. Krishnan E, Kwoh CK, Schumacher HR, et al. Hyperuricemia and incidence of hypertension among men without metabolic syndrome. Hypertension. 2007; 49(2): 298–303.
    CrossRefPubMed
  78. Masuo K, Kawaguchi H, Mikami H, et al. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension. 2003; 42(4): 474–480.
    CrossRefPubMed
  79. Mellen P, Bleyer A, Erlinger T, et al. Serum Uric Acid Predicts Incident Hypertension in a Biethnic Cohort. Hypertension. 2006; 48(6): 1037–1042.
    CrossRef
  80. Nagahama K, Inoue T, Iseki K, et al. Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan. Hypertension Res. 2004; 27(11): 835–841.
    CrossRef
  81. Taniguchi Y, Hayashi T, Tsumura K, et al. Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: The Osaka Health Survey. J Hypertens. 2001; 19(7): 1209–1215.
    PubMed
  82. Kang DH, Nakagawa T, Feng L, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002; 13(12): 2888–2897.
    PubMed
  83. Syamala S, Li J, Shankar A. Association between serum uric acid and prehypertension among US adults. J Hypertens. 2007; 25(8): 1583–1589.
    CrossRefPubMed
  84. Grayson PC, Kim SY, LaValley M, et al. Hyperuricemia and incident hypertension: a systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2011; 63(1): 102–110.
    CrossRefPubMed
  85. Bombelli M, Ronchi I, Volpe M, et al. Prognostic value of serum uric acid: new-onset in and out-of-office hypertension and long-term mortality. J Hypertens. 2014; 32(6): 1237–1244.
    CrossRefPubMed
  86. Perlstein TS, Gumieniak O, Williams GH, et al. Uric acid and the development of hypertension: the normative aging study. Hypertension. 2006; 48(6): 1031–1036.
    CrossRefPubMed
  87. Forman JP, Choi H, Curhan GC. Uric acid and insulin sensitivity and risk of incident hypertension. Arch Intern Med. 2009; 169(2): 155–162.
    CrossRefPubMed
  88. Zhang W, Sun K, Yang Y, et al. Plasma uric acid and hypertension in a Chinese community: prospective study and metaanalysis. Clin Chem. 2009; 55(11): 2026–2034.
    CrossRefPubMed
  89. Shankar A, Klein R, Klein BEK, et al. The association between serum uric acid level and long-term incidence of hypertension: Population-based cohort study. J Hum Hypertens. 2006; 20(12): 937–945.
    CrossRefPubMed
  90. Sundström J, Sullivan L, D'Agostino RB, et al. Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. Hypertension. 2005; 45(1): 28–33.
    CrossRefPubMed
  91. Kuwabara M, Hisatome I, Niwa K, et al. Uric acid is a strong risk marker for developing hypertension from prehypertension: a 5-year Japanese Cohort Study. Hypertension. 2018; 71(1): 78–86.
    CrossRefPubMed
  92. Norvik JV, et al. Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromso Study. BMC Cardiovasc Disord. 2016; 16: 85.
  93. Juraschek SP, Kovell LC, Miller ER, et al. Association of kidney disease with prevalent gout in the United States in 1988-1994 and 2007-2010. Semin Arthritis Rheum. 2013; 42(6): 551–561.
    CrossRefPubMed
  94. Jing J, Kielstein JT, Schultheiss UT, et al. Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease: the German Chronic Kidney Disease (GCKD) study. Nephrol Dial Transplant. 2015; 30(4): 613–621.
    CrossRefPubMed
  95. Johnson RJ, Nakagawa T, Jalal D, et al. Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant. 2013; 28(9): 2221–2228.
    CrossRefPubMed
  96. Hsu Cy, Iribarren C, McCulloch CE, et al. Risk factors for end-stage renal disease: 25-year follow-up. Arch Intern Med. 2009; 169(4): 342–350.
    CrossRefPubMed
  97. Myllymäki J, Honkanen T, Syrjänen J, et al. Uric acid correlates with the severity of histopathological parameters in IgA nephropathy. Nephrol Dial Transplant. 2005; 20(1): 89–95.
    CrossRefPubMed
  98. Liu P, Chen Y, Wang B, et al. Allopurinol treatment improves renal function in patients with type 2 diabetes and asymptomatic hyperuricemia: 3-year randomized parallel-controlled study. Clin Endocrinol (Oxf). 2015; 83(4): 475–482.
    CrossRefPubMed
  99. Hart A, Jackson S, Kasiske BL, et al. Uric acid and allograft loss from interstitial fibrosis/tubular atrophy: post hoc analysis from the angiotensin II blockade in chronic allograft nephropathy trial. Transplantation. 2014; 97(10): 1066–1071.
    CrossRefPubMed
  100. Bellomo G, Venanzi S, Verdura C, et al. Association of uric acid with change in kidney function in healthy normotensive individuals. Am J Kidney Dis. 2010; 56(2): 264–272.
    CrossRefPubMed
  101. Obermayr RP, Temml C, Knechtelsdorfer M, et al. Predictors of new-onset decline in kidney function in a general middle-european population. Nephrol Dial Transplant. 2008; 23(4): 1265–1273.
    CrossRefPubMed
  102. Bos MJ, Koudstaal PJ, Hofman A, et al. Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study. Stroke. 2006; 37(6): 1503–1507.
    CrossRefPubMed
  103. Ruggiero C, Cherubini A, Lauretani F, et al. Uric acid and dementia in community-dwelling older persons. Dement Geriatr Cogn Disord. 2009; 27(4): 382–389.
    CrossRefPubMed
  104. Lu Na, Dubreuil M, Zhang Y, et al. Gout and the risk of Alzheimer's disease: a population-based, BMI-matched cohort study. Ann Rheum Dis. 2016; 75(3): 547–551.
    CrossRefPubMed
  105. Yan DD, Wang J, Hou XH, et al. Association of serum uric acid levels with osteoporosis and bone turnover markers in a Chinese population. Acta Pharmacol Sin. 2018; 39(4): 626–632.
    CrossRefPubMed
  106. Stack AG, Hanley A, Casserly LF, et al. Independent and conjoint associations of gout and hyperuricaemia with total and cardiovascular mortality. QJM. 2013; 106(7): 647–658.
    CrossRefPubMed
  107. Ioachimescu AG, Brennan DM, Hoar BM, et al. Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study. Arthritis Rheum. 2008; 58(2): 623–630.
    CrossRefPubMed
  108. Choi HK, Curhan G. Independent impact of gout on mortality and risk for coronary heart disease. Circulation. 2007; 116(8): 894–900.
    CrossRefPubMed
  109. Kuo CF, See LC, Yu KH, et al. Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality. Rheumatology (Oxford). 2013; 52(1): 127–134.
    CrossRefPubMed
  110. Tamariz L, Harzand A, Palacio A, et al. Uric acid as a predictor of all-cause mortality in heart failure: a meta-analysis. Congest Heart Fail. 2011; 17(1): 25–30.
    CrossRefPubMed
  111. Thanassoulis G, Brophy JM, Richard H, et al. Gout, allopurinol use, and heart failure outcomes. Arch Intern Med. 2010; 170(15): 1358–1364.
    CrossRefPubMed
  112. Krishnan E, Pandya BJ, Lingala B, et al. Hyperuricemia and untreated gout are poor prognostic markers among those with a recent acute myocardial infarction. Arthritis Res Ther. 2012; 14(1): R10.
    CrossRefPubMed
  113. Tscharre M, Herman R, Rohla M, et al. Uric acid is associated with long-term adverse cardiovascular outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention. Atherosclerosis. 2018; 270: 173–179.
    CrossRefPubMed
  114. Andrés M, Quintanilla MA, Sivera F, et al. Silent monosodium urate crystal deposits are associated with severe coronary calcification in asymptomatic hyperuricemia: an exploratory study. Arthritis Rheumatol. 2016; 68(6): 1531–1539.
    CrossRefPubMed
  115. Holme I, Aastveit AH, Hammar N, et al. Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). J Intern Med. 2009; 266(6): 558–570.
    CrossRefPubMed
  116. Crosta F, Occhiuzzi U, Passalacqua G, et al. Association Between the Serum Uric Acid Levels and Lacunar Infarcts in the Elderly. J Mol Neurosci. 2018; 65(3): 385–390.
    CrossRefPubMed
  117. White WB, Saag KG, Becker MA, et al. CARES Investigators. Cardiovascular safety of febuxostat or allopurinol in patients with gout. N Engl J Med. 2018; 378(13): 1200–1210.
    CrossRefPubMed
  118. MacIsaac RL, Salatzki J, Higgins P, et al. Allopurinol and cardiovascular outcomes in adults with hypertension. Hypertension. 2016; 67(3): 535–540.
    CrossRefPubMed
  119. Goicoechea M, Garcia de Vinuesa S, Verdalles U, et al. Allopurinol and progression of CKD and cardiovascular events: long-term follow-up of a randomized clinical trial. Am J Kidney Dis. 2015; 65(4): 543–549.
    CrossRefPubMed
  120. Becker MA, Schumacher HR, Espinoza LR, et al. The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial. Arthritis Res Ther. 2010; 12(2): R63.
    CrossRefPubMed
  121. Bredemeier M, Lopes LM, Eisenreich MA, et al. Xanthine oxidase inhibitors for prevention of cardiovascular events: a systematic review and meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2018; 18(1): 24.
    CrossRefPubMed
  122. Frampton JE. Febuxostat: a review of its use in the treatment of hyperuricaemia in patients with gout. Drugs. 2015; 75(4): 427–438.
    CrossRefPubMed
  123. Kim SC, Neogi T, Kang EHa, et al. Cardiovascular risks of probenecid versus allopurinol in older patients with gout. J Am Coll Cardiol. 2018; 71(9): 994–1004.
    CrossRefPubMed
  124. Szwejkowski BR, Gandy SJ, Rekhraj S, et al. Allopurinol reduces left ventricular mass in patients with type 2 diabetes and left ventricular hypertrophy. J Am Coll Cardiol. 2013; 62(24): 2284–2293.
    CrossRefPubMed
  125. Akkineni R, Tapp S, Tosteson ANA, et al. Treatment of asymptomatic hyperuricemia and prevention of vascular disease: a decision analytic approach. J Rheumatol. 2014; 41(4): 739–748.
    CrossRefPubMed
  126. Zhang T, Pope JE. Cardiovascular effects of urate-lowering therapies in patients with chronic gout: a systematic review and meta-analysis. Rheumatology (Oxford). 2017; 56(7): 1144–1153.
    CrossRefPubMed
  127. Richette P, Latourte A, Bardin T. Cardiac and renal protective effects of urate-lowering therapy. Rheumatology (Oxford). 2018; 57(suppl_1): i47–i50.
    CrossRefPubMed
  128. Wei Li, Mackenzie IS, Chen Y, et al. Impact of allopurinol use on urate concentration and cardiovascular outcome. Br J Clin Pharmacol. 2011; 71(4): 600–607.
    CrossRefPubMed
  129. Richette P, Perez-Ruiz F, Doherty M, et al. Improving cardiovascular and renal outcomes in gout: what should we target? Nat Rev Rheumatol. 2014; 10(11): 654–661.
    CrossRefPubMed
  130. Okafor ON, Farrington K, Gorog DA. Allopurinol as a therapeutic option in cardiovascular disease. Pharmacol Ther. 2017; 172: 139–150.
    CrossRefPubMed
  131. Perez-Ruiz F, Martínez-Indart L, Carmona L, et al. Tophaceous gout and high level of hyperuricaemia are both associated with increased risk of mortality in patients with gout. Ann Rheum Dis. 2014; 73(1): 177–182.
    CrossRefPubMed
  132. Pacher P, Nivorozhkin A, Szabó C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006; 58(1): 87–114.
    CrossRefPubMed
  133. Wei Li, Mackenzie IS, Chen Y, et al. Impact of allopurinol use on urate concentration and cardiovascular outcome. Br J Clin Pharmacol. 2011; 71(4): 600–607.
    CrossRefPubMed
  134. Wei L, Fahey T, Struthers AD, et al. Association between allopurinol and mortality in heart failure patients: a long-term follow-up study. Int J Clin Pract. 2009; 63(9): 1327–1333.
    CrossRefPubMed
  135. Dubreuil M, Zhu Y, Zhang Y, et al. Allopurinol initiation and all-cause mortality in the general population. Ann Rheum Dis. 2015; 74(7): 1368–1372.
    CrossRefPubMed
  136. Noman A, Ang DSC, Ogston S, et al. Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial. Lancet. 2010; 375(9732): 2161–2167.
    CrossRefPubMed
  137. Rekhraj S, Gandy SJ, Szwejkowski BR, et al. High-dose allopurinol reduces left ventricular mass in patients with ischemic heart disease. J Am Coll Cardiol. 2013; 61(9): 926–932.
    CrossRefPubMed
  138. Higgins P, Dawson J, Lees KR, et al. Xanthine oxidase inhibition for the treatment of cardiovascular disease: a systematic review and meta-analysis. Cardiovasc Ther. 2012; 30(4): 217–226.
    CrossRefPubMed
  139. George J, Carr E, Davies J, et al. High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation. 2006; 114(23): 2508–2516.
    CrossRefPubMed
  140. Givertz MM, Anstrom KJ, Redfield MM, et al. Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study. Circulation. 2015; 131(20): 1763–1771.
    CrossRefPubMed
  141. Cleland JGF, Coletta AP, Clark AL. Clinical trials update from the Heart Failure Society of America meeting: FIX-CHF-4, selective cardiac myosin activator and OPT-CHF. Eur J Heart Fail. 2006; 8(7): 764–766.
    CrossRefPubMed
  142. Freudenberger RS, Schwarz RP, Brown J, et al. Rationale, design and organisation of an efficacy and safety study of oxypurinol added to standard therapy in patients with NYHA class III - IV congestive heart failure. Expert Opin Investig Drugs. 2004; 13(11): 1509–1516.
    CrossRefPubMed
  143. George J, Struthers A. The OPT-CHF (Oxypurinol Therapy for Congestive Heart Failure) trial: a question of dose. J Am Coll Cardiol. 2009; 53(25): 2405.
    CrossRefPubMed
  144. Hare JM, Mangal B, Brown J, et al. Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study. J Am Coll Cardiol. 2008; 51(24): 2301–2309.
    CrossRefPubMed
  145. Beattie CJ, Fulton RL, Higgins P, et al. Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension. 2014; 64(5): 1102–1107.
    CrossRefPubMed
  146. Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA. 2008; 300(8): 924–932.
    CrossRefPubMed
  147. Agarwal V, Hans N, Messerli FH. Effect of allopurinol on blood pressure: a systematic review and meta-analysis. J Clin Hypertens (Greenwich). 2013; 15(6): 435–442.
    CrossRefPubMed
  148. Kostka-Jeziorny K, Uruski P, Tykarski A. Effect of allopurinol on blood pressure and aortic compliance in hypertensive patients. Blood Press. 2011; 20(2): 104–110.
    CrossRefPubMed
  149. Khan F, George J, Wong K, et al. Allopurinol treatment reduces arterial wave reflection in stroke survivors. Cardiovasc Ther. 2008; 26(4): 247–252.
    CrossRefPubMed
  150. Soletsky B, Feig DI. Uric acid reduction rectifies prehypertension in obese adolescents. Hypertension. 2012; 60(5): 1148–1156.
    CrossRefPubMed
  151. Borghi C, Omboni S, Reggiardo G, et al. Effects of the concomitant administration of xanthine oxidase inhibitors with zofenopril or other ACE-inhibitors in post-myocardial infarction patients: a meta-analysis of individual data of four randomized, double-blind, prospective studies. BMC Cardiovasc Disord. 2018; 18(1): 112.
    CrossRefPubMed
  152. Luk AJ, Levin GP, Moore EE, et al. Allopurinol and mortality in hyperuricaemic patients. Rheumatology (Oxford). 2009; 48(7): 804–806.
    CrossRefPubMed
  153. Ueno S, Hamada T, Taniguchi S, et al. Effect of antihypertensive drugs on uric acid metabolism in patients with hypertension: cross-sectional cohort study. Drug Res (Stuttg). 2016; 66(12): 628–632.
    CrossRefPubMed
  154. Kai H, Ueda T, Uchiwa H, et al. Benefit of losartan/hydrochlorothiazide-fixed dose combination treatment for isolated morning hypertension: The MAPPY study. Clin Exp Hypertens. 2015; 37(6): 473–481.
    CrossRefPubMed
  155. Matsumura K, Arima H, Tominaga M, et al. Effect of losartan on serum uric acid in hypertension treated with a diuretic: the COMFORT study. Clin Exp Hypertens. 2015; 37(3): 192–196.
    CrossRefPubMed
  156. Okamura K, Shirai K, Totake N, et al. Prospective direct comparison of antihypertensive effect and safety between high-dose amlodipine or indapamide in hypertensive patients uncontrolled by standard doses of angiotensin receptor blockers and amlodipine. Clin Exp Hypertens. 2018; 40(2): 99–106.
    CrossRefPubMed
  157. Derosa G, Maffioli P, Sahebkar A. Plasma uric acid concentrations are reduced by fenofibrate: A systematic review and meta-analysis of randomized placebo-controlled trials. Pharmacol Res. 2015; 102: 63–70.
    CrossRefPubMed
  158. Milionis HJ, Kakafika AI, Tsouli SG, et al. Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia. Am Heart J. 2004; 148(4): 635–640.
    CrossRefPubMed
  159. Chino Y, Samukawa Y, Sakai S, et al. SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria. Biopharm Drug Dispos. 2014; 35(7): 391–404.
    CrossRefPubMed
  160. Kanji T, Gandhi M, Clase CM, et al. Urate lowering therapy to improve renal outcomes in patients with chronic kidney disease: systematic review and meta-analysis. BMC Nephrol. 2015; 16: 58.
    CrossRefPubMed
  161. Goicoechea M, de Vinuesa SG, Verdalles U, et al. Effect of allopurinol in chronic kidney disease progression and cardiovascular risk. Clin J Am Soc Nephrol. 2010; 5(8): 1388–1393.
    CrossRefPubMed
  162. Su X, Xu B, Yan B, et al. Effects of uric acid-lowering therapy in patients with chronic kidney disease: A meta-analysis. PLoS One. 2017; 12(11): e0187550.
    CrossRefPubMed
  163. Siu YP, Leung KT, Tong MKH, et al. Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am J Kidney Dis. 2006; 47(1): 51–59.
    CrossRefPubMed
  164. Sampson AL, Singer RF, Walters GD. Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease. Cochrane Database Syst Rev. 2017; 10: CD009460.
    CrossRefPubMed
  165. Levy GD, Rashid N, Niu F, et al. Effect of urate-lowering therapies on renal disease progression in patients with hyperuricemia. J Rheumatol. 2014; 41(5): 955–962.
    CrossRefPubMed
  166. Becker MA, Schumacher HR, Wortmann RL, et al. Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med. 2005; 353(23): 2450–2461.
    CrossRefPubMed
  167. Whelton A, MacDonald PA, Chefo S, et al. Preservation of renal function during gout treatment with febuxostat: a quantitative study. Postgrad Med. 2013; 125(1): 106–114.
    CrossRefPubMed
  168. Kimura K, Hosoya T, Uchida S, et al. Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial. Am J Kidney Dis. 2018 [Epub ahead of print].
    CrossRefPubMed
  169. Richette P, Doherty M, Pascual E, et al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2017; 76(1): 29–42.
    CrossRefPubMed
  170. Khanna D, Fitzgerald JD, Khanna PP, et al. 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken). 2012; 64(10): 1431–1446.
    CrossRefPubMed
  171. Hui M, Carr A, Cameron S, et al. The British Society for Rheumatology Guideline for the Management of Gout. Rheumatology. 2017; 56(7): 1246.
    CrossRef
  172. Roddy E, Packham J, Obrenovic K, et al. Management of gout by UK rheumatologists: a British Society for Rheumatology national audit. Rheumatology (Oxford). 2018; 57(5): 826–830.
    CrossRefPubMed
  173. Fotherby MD, Potter JF. Metabolic and orthostatic blood pressure responses to a low-sodium diet in elderly hypertensives. J Hum Hypertens. 1997; 11(6): 361–366.
    PubMed
  174. Singh JA, Reddy SG, Kundukulam J. Risk factors for gout and prevention: a systematic review of the literature. Curr Opin Rheumatol. 2011; 23(2): 192–202.
    CrossRefPubMed
  175. Jacob RA, Spinozzi GM, Simon VA, et al. Consumption of cherries lowers plasma urate in healthy women. J Nutr. 2003; 133(6): 1826–1829.
    CrossRefPubMed
  176. Schlesinger N. Dietary factors and hyperuricaemia. Curr Pharm Des. 2005; 11(32): 4133–4138.
    PubMed
  177. Richette P, Poitou C, Manivet P, et al. Weight Loss, Xanthine Oxidase, and Serum Urate Levels: A Prospective Longitudinal Study of Obese Patients. Arthritis Care Res (Hoboken). 2016; 68(7): 1036–1042.
    CrossRefPubMed
  178. Chen JH, Wen CP, Wu SB, et al. Attenuating the mortality risk of high serum uric acid: the role of physical activity underused. Ann Rheum Dis. 2015; 74(11): 2034–2042.
    CrossRefPubMed
  179. Borghi C, Perez-Ruiz F. Urate lowering therapies in the treatment of gout: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 2016; 20(5): 983–992.
    PubMed
  180. Neogi T, et al. Renal dosing of allopurinol results in suboptimal gout care. Ann Rheum Dis. 2017; 76(1): e1.
  181. Stamp LK, O'Donnell JL, Zhang M, et al. Using allopurinol above the dose based on creatinine clearance is effective and safe in patients with chronic gout, including those with renal impairment. Arthritis Rheum. 2011; 63(2): 412–421.
    CrossRefPubMed
  182. Rees F, Jenkins W, Doherty M. Patients with gout adhere to curative treatment if informed appropriately: proof-of-concept observational study. Ann Rheum Dis. 2013; 72(6): 826–830.
    CrossRefPubMed
  183. Ramasamy S, Korb-Wells C, Kannangara D, et al. Allopurinol Hypersensitivity: A Systematic Review of All Published Cases, 1950–2012. Drug Safety. 2013; 36(10): 953–980.
    CrossRef
  184. Hershfield MS, Callaghan JT, Tassaneeyakul W, et al. Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing. Clin Pharmacol Ther. 2013; 93(2): 153–158.
    CrossRefPubMed
  185. Hande KR, Noone RM, Stone WJ. Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency. Am J Med. 1984; 76(1): 47–56.
  186. Baldus S, Köster R, Chumley P, et al. Oxypurinol improves coronary and peripheral endothelial function in patients with coronary artery disease. Free Radic Biol Med. 2005; 39(9): 1184–1190.
    CrossRefPubMed
  187. Guan W, Osanai T, Kamada T, et al. Effect of allopurinol pretreatment on free radical generation after primary coronary angioplasty for acute myocardial infarction. J Cardiovasc Pharmacol. 2003; 41(5): 699–705.
    CrossRef
  188. Baldus S, Müllerleile K, Chumley P, et al. Inhibition of xanthine oxidase improves myocardial contractility in patients with ischemic cardiomyopathy. Free Radic Biol Med. 2006; 41(8): 1282–1288.
    CrossRefPubMed
  189. Cappola T. Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy. Circulation. 2001; 104(20): 2407–2411.
  190. Scirè CA, Rossi C, Punzi L, et al. Change gout: how to deal with this. Curr Med Res Opin. 2018; 34(8): 1411–1417.
    CrossRefPubMed
  191. Saag KG, Fitz-Patrick D, Kopicko J, et al. Lesinurad combined with allopurinol: a randomized, double-blind, placebo-controlled study in gout patients with an inadequate response to standard-of-care allopurinol (a US-based study). Arthritis Rheumatol. 2017; 69(1): 203–212.
    CrossRefPubMed
  192. Jones G, Panova E, Day R. Guideline development for the management of gout: role of combination therapy with a focus on lesinurad. Drug Des Devel Ther. 2017; 11: 3077–3081.
    CrossRefPubMed
  193. Huneycutt E, Board C, Clements JN. Lesinurad, a selective URAT-1 inhibitor with a novel mechanism in combination with a xanthine oxidase inhibitor, for hyperuricemia associated with gout. J Pharm Pract. 2017 [Epub ahead of print]: 897190017734427.
    CrossRefPubMed
  194. Deeks ED. Lesinurad: a review in hyperuricaemia of gout. Drugs Aging. 2017; 34(5): 401–410.
    CrossRefPubMed
  195. Ruoff G, Edwards NL. Overview of serum uric acid treatment targets in gout: why less than 6 mg/dL? Postgrad Med. 2016; 128(7): 706–715.
    CrossRefPubMed
  196. FitzGerald JD, Mikuls TR, Neogi T, et al. Development of the American College of Rheumatology Electronic Clinical Quality Measures for Gout. Arthritis Care Res (Hoboken). 2018; 70(5): 659–671.
    CrossRefPubMed
  197. Khanna D, Fitzgerald JD, Khanna PP, et al. 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken). 2012; 64(10): 1431–1446.
    CrossRefPubMed

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