Vol 29, No 6 (2022)
Letter to the Editor
Published online: 2022-12-13

open access

Page views 3456
Article views/downloads 381
Get Citation

Connect on Social Media

Connect on Social Media

Inquiries about a patient with a “snail-like” takotsubo syndrome variant. Authors’ reply

Alicja Genc1, Jakub Sobolewski1, Witold Bachorski1, Izabela Pisowodzka1, Miłosz Jaguszewski1, Marcin Fijałkowski1
Pubmed: 36541351
Cardiol J 2022;29(6):1051-1052.


Not available



Cardiology Journal

2022, Vol. 29, No. 6, 1051–1052

DOI: 10.5603/CJ.2022.0113

Copyright © 2022 Via Medica

ISSN 1897–5593

eISSN 1898–018X

Inquiries about a patient with a “snail-like” takotsubo syndrome variant. Authors’ reply

Alicja GencJakub SobolewskiWitold BachorskiIzabela PisowodzkaMiłosz JaguszewskiMarcin Fijałkowski
First Department of Cardiology, Medical University of Gdansk, Poland

Address for correspondence: Alicja Genc, MD, First Department of Cardiology, Medical University of Gdansk, ul. Dębinki 7, 80952 Gdańsk, Poland, tel: +48 58 584 47 10, fax: +48 58 346 12 01, e-mail: alicja.genc@gumed.edu.pl

Received: 24.08.2022 Accepted: 3.09.2022

This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

This article is accompanied by the editorial on page 897

We appreciate John E. Madias’ interest and comments on our case report recently published in the Cardiology Journal, which generated great interest [1]. We would like to dispel any doubts about the course of the disease and the echocardio­graphy and electrocardiography (ECG) findings in our patient with the “snail-like” takotsubo variant. Unfortunately, Images in Cardiovascular Medicine have a restrictive word limit; however, herein, we can kindly provide further details on our case.

The patient suffered from recurrent chest pain for 2 days, provoked by stress and released after nitroglycerin intake. The troponin level was the highest on admission to the hospital (3.4 ng/mL), then it decreased. The maximum marked B-type natriuretic peptide concentration (120 pg/mL) occurred the day after hospital admission when the patient reported no symptoms. A discharge echocardiogram revealed residual akinesis of the medium segment of the anterior wall and the anterior part of an intraventricular septum. The patient was followed-up twice. The echocardiography showed a contractility improvement, but the hypokinesis was still present 3 weeks after discharge. After 5 weeks, the echo examination was without any abnormalities. The regional longitudinal strain during the 5-week follow-up improved but was still slightly worse in the hypokinetic segments (see: Bull’s Eye Plot, Fig. 1). Among the drugs taken before hospitalization were: sotalol, candesartan, hydrochlorothiazide, lercanidipine, rosuvastatin, acenocoumarol, levothyroxine, and metformin. The QTc was slightly shortened during hospitalization, but interestingly on the 4th day of hospitalization, there was an episode of atrial fibrillation. After electrical cardioversion, the QTc interval extended to 479 ms. Certainly, QTc was shortened after a 3-week follow-up; it was 421 ms.

Figure 1. A. Bull’s Eye Plot presenting global longitudinal strain (GLS) on the day of admission to the hospital; B. Bull’s Eye Plot presenting GLS after 5-week follow-up, C. Electrocardiogram done on the day of admission to the hospital.

The ST segment elevations in leads II, III, and aVF revealed the importance of repeated examinations and appropriate interpretation. We reanalyzed the available ECGs thanks to Madias’ question and concluded that the ECG leads had been switched in the Emergency Department. The ST segment elevations in II, III, and aVF were only observed in the first ECG. The next ECGs revealed ST segment elevations in I, aVL and T waves inversions in I, aVL, and positive-negative T waves in V2V4 (Fig. 1). At discharge, T waves were inverted in V1 and positive-negative in V2. Interestingly, in a 3-week follow-up, negative T waves in I, aVL, V2 and positive-negative T waves in V3V5 were observed.

We presented this unique case not only because of localization but also because monitoring laboratory parameters and serial ECGs affect the overall course of the disease.

Conflict of interest: None declared


  1. Genc A, Sobolewski J, Bachorski W, et al. The focal takotsubo syndrome presenting with the snail-like left ventricle. Cardiol J. 2021; 28(4): 636–637, doi: 10.5603/CJ.2021.0068, indexed in Pubmed: 34240396.