open access

Vol 29, No 4 (2022)
Study Protocol
Submitted: 2022-03-24
Accepted: 2022-05-27
Published online: 2022-06-09
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Safety and efficacy of His bundle pacing validated by extracardiac vagal nerve stimulation (HIS-STORY)

Krystian Josiak12, Sebastian Stec3, Dorota Zyśko1, Bartosz Skonieczny1, Jaroslaw Kosior4, Janusz Śledź4, Antoni Wilczek3, Edyta Stodółkiewicz-Nowarska56, Bartosz Biel1, Paweł Szymkiewicz1, Przemysław Skoczyński1, Dariusz Karbarz4, Bartosz Ludwik7, Waldemar Banasiak1, Dariusz Jagielski1
DOI: 10.5603/CJ.a2022.0053
Pubmed: 35703044
Cardiol J 2022;29(4):698-701.
  1. Cardiology Department, 4th Military Hospital, Wroclaw, Poland
  2. Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland, Wroclaw, Poland
  3. Subcarpathian Center for Cardiovascular Intervention, Sanok, Poland
  4. Cardiology Department, Mazovian Speciality Hospital, Radom, Poland
  5. CardioMedicum, Krakow, Poland
  6. Department of Interventional Cardiology, Cardiovascular Center, American Heart of Poland, Chrzanow, Poland
  7. Department of Cardiology, Regional Specialist Hospital Centre for Research and Development, Wroclaw, Poland

open access

Vol 29, No 4 (2022)
Study protocol — Clinical cardiology
Submitted: 2022-03-24
Accepted: 2022-05-27
Published online: 2022-06-09


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Safety and efficacy of His bundle pacing validated by extracardiac vagal nerve stimulation (HIS-STORY)


Cardiology Journal


Vol 29, No 4 (2022)

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Study Protocol



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Bibliographic record

Cardiol J 2022;29(4):698-701.


Krystian Josiak
Sebastian Stec
Dorota Zyśko
Bartosz Skonieczny
Jaroslaw Kosior
Janusz Śledź
Antoni Wilczek
Edyta Stodółkiewicz-Nowarska
Bartosz Biel
Paweł Szymkiewicz
Przemysław Skoczyński
Dariusz Karbarz
Bartosz Ludwik
Waldemar Banasiak
Dariusz Jagielski

References (12)
  1. Deshmukh P, Casavant D, Romanyshyn M, et al. Permanent, direct His-bundle pacing. Circulation. 2000; 101(8): 869–877.
  2. Glikson M, Nielsen J, Kronborg M, et al. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy. Eur Heart J. 2021; 42(35): 3427–3520.
  3. Pachon JC, Pachon EI, Pachon JC, et al. "Cardioneuroablation"--new treatment for neurocardiogenic syncope, functional AV block and sinus dysfunction using catheter RF-ablation. Europace. 2005; 7(1): 1–13.
  4. Wileczek A, Polewczyk A, Kluk M, et al. Ultrasound-guided imaging for vagus nerve stimulation to facilitate cardioneuroablation for the treatment of functional advanced atrioventricular block. Indian Pacing Electrophysiol J. 2021; 21(6): 403–406.
  5. Pachon M JC, Pachon M EI, Santillana P TG, et al. Simplified method for vagal effect evaluation in cardiac ablation and electrophysiological procedures. JACC Clin Electrophysiol. 2015; 1(5): 451–460.
  6. Zyśko D, Gajek J, Koźluk E, et al. Electrocardiographic characteristics of atrioventricular block induced by tilt testing. Europace. 2009; 11(2): 225–230.
  7. Aksu T, Guler TE, Bozyel S, et al. Potential usage of cardioneuroablation in vagally mediated functional atrioventricular block. SAGE Open Med. 2019; 7: 2050312119836308.
  8. Stec S, Dobaj Ł, Śledź A, et al. Cardioneuroablation for management of cardioinhibitory vasovagal syncope and pacemaker complications. HeartRhythm Case Rep. 2020; 6(8): 531–534.
  9. Tsun L, Chow LT, Chow SS, et al. Autonomic innervation of the human cardiac conduction system: changes from infancy to senility--an immunohistochemical and histochemical analysis. Anat Rec. 2001; 264(2): 169–182.
  10. Coote JH. Myths and realities of the cardiac vagus. J Physiol. 2013; 591(17): 4073–4085.
  11. A Study to Evaluate the Effect of Vagus Nerve Stimulation in Patients Undergoing VT Ablation Identifier: NCT04359004.
  12. Stec S, Jankowska-Polańska B, Jagielski D, et al. Rationale and design of SAN.OK_1 randomized controlled clinical trial and registry: Comparison of Early vs Late Permanent Pacemaker Implantation and Cardioneuroablation in Sinus Node Dysfunction. Identifier: NCTO5196126.


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