Vol 30, No 1 (2023)
Letter to the Editor
Published online: 2023-01-30

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COVID-19 and long-COVID-19 syndrome related myocarditis: The heart rhythm matters

Andrzej Glowniak12, Katarzyna Wojewoda23, Adam Tarkowski2
Pubmed: 36790044
Cardiol J 2023;30(1):165-166.

Abstract

Not available

covid-19

LETTER TO THE EDITOR

Cardiology Journal

2023, Vol. 30, No. 1, 165–166

DOI: 10.5603/CJ.a2023.0005

Copyright © 2023 Via Medica

ISSN 1897–5593

eISSN 1898–018X

COVID-19 and long-COVID-19 syndrome related myocarditis: The heart rhythm matters

Andrzej Glowniak12Katarzyna Wojewoda23Adam Tarkowski2
1Department of Cardiology, Medical University of Lublin, Poland
2Clinical Department of Electrocardiology, SPSK-4 University Hospital, Lublin, Poland
3Doctoral School, Medical University of Lublin, Poland

Address for correspondence: Andrzej Glowniak, MD, PhD, Clinical Department of Electrocardiology, SPSK-4 University Hospital, ul. Jaczewskiego 8, 20954 Lublin, Poland, tel/fax: +48 81 724 41 51, e-mail: andrzej.glowniak@gmail.com

Received: 18.12.2021 Accepted: 27.01.2023 Early publication date: 30.01.2023

This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to respiratory distress as the main manifestation in most patients, though there are also well-documented cardiovascular complications. It is with great interest that we read the paper by Szarpak et al. [1] regarding the cardiac complications of coronavirus disease 2019 (COVID-19) and long-COVID-19 syndrome. This manuscript is important and soundly covers a vast area of SARS-CoV-2 infection related cardiologic concerns. There is definite agreement that the post-COVID-19 myocarditis is a real threat, and its occurrence is most probably underestimated [2–4]. Moreover, SARS-CoV-2 infection may be followed by long-term extrapulmonary organ manifestations, with relatively frequent cardiac involvement [5]. All the more, the lack of reference to the reported post COVID-19 myocarditis-related heart rhythm disturbances are evident.

Indeed, most of the reported arrhythmias occur during the acute phase of the SARS-CoV-2 infection [6], however there are reports on clinically relevant heart rhythm disturbances in the course of post-COVID-19 myocarditis. As reported by Al-Assaf et al. [7], COVID-19 related myocarditis can manifest with permanent high-degree atrioventricular (AV) block, requiring cardiac pacemaker implantation. Conversely, in our recently published report [8] we described a case of symptomatic complete AV block in the course of post-COVID-19 myocarditis, requiring transvenous temporary cardiac pacing, that resolved spontaneously within 48 hours, and subsequent electrophysiological study as well as long-term electrocardiography (ECG) monitoring revealed normal AV conduction. The patient was discharged home without a permanent pacemaker, and 24-hour Holter monitoring performed at one-month follow-up revealed no AV conduction disturbances. Similarly, in another reported case-series of 3 patients with symptomatic COVID-19-related transient AV block, none of them required permanent cardiac pacing [9], however in 2 of the described patients the conduction disturbances occurred early in the acute phase of SARS-CoV-2 infection.

There are several possible mechanisms of cardiac damage in COVID-19, including hypoxemia, endothelial dysfunction, coronary artery thrombosis and cytokine-storm resulting in the myocardial damage [10]. This can also affect the cardiac conduction system, leading to potentially life-threating arrhythmias. In the settings of subclinical course of myocarditis, sudden cardiac death can be the only (and fatal) manifestation, which occurs weeks (or possibly months) after the acute phase of infection. In the described case, the development of the cardiac conduction system disease in a COVID-19 convalescent should raise awareness of possible long-term cardiac complications following SARS--CoV-2 infection. In a large-cohort observational study [6] the risk of such complication was increased in patients with associated comorbidities: hypertension, diabetes, heart failure and coronary artery disease. Interestingly, most of the patients with COVID-related heart rhythm disturbances had no previous history of arrhythmia [6]. Considering these findings, it is believed herein, closer follow--up with ECG monitoring should be recommended in selected post-COVID-19 patients with multiple cardiovascular comorbidities, as illustrated on the proposed scheme (Fig. 1).

Figure 1. Proposed post coronavirus disease 2019 (COVID-19) follow-up scheme to identify late-onset cardiac arrhythmias; SARS-CoV-2 — severe acute respiratory syndrome coronavirus 2.
Conflict of interest: None declared

References

  1. Szarpak L, Pruc M, Filipiak KJ, et al. Myocarditis: A complication of COVID-19 and long-COVID-19 syndrome as a serious threat in modern cardiology. Cardiol J. 2022; 29(1): 178–179, doi: 10.5603/CJ.a2021.0155, indexed in Pubmed: 34811716.
  2. Boehmer TK, Kompaniyets L, Lavery AM, et al. Association between COVID-19 and myocarditis using hospital-based administrative data - United States, March 2020-January 2021. MMWR Morb Mortal Wkly Rep. 2021; 70(35): 1228–1232, doi: 10.15585/mmwr.mm7035e5, indexed in Pubmed: 34473684.
  3. Kubica J, Ostrowska M, Stolarek W, et al. Impact of COVID-19 pandemic on acute heart failure admissions and mortality: a multicentre study (COV-HF-SIRIO 6 study). ESC Heart Fail. 2022; 9(1): 721–728, doi: 10.1002/ehf2.13680, indexed in Pubmed: 34786869.
  4. Eiros R, Barreiro-Perez M, Martin-Garcia A, et al. Pericarditis and myocarditis long after SARS-CoV-2 infection: a cross-sectional descriptive study in health-care workers. medRxiv. 2020, doi: 10.1101/2020.07.12.20151316.
  5. Gasecka A, Pruc M, Kukula K, et al. Post-COVID-19 heart syndrome. Cardiol J. 2021; 28(2): 353–354, doi: 10.5603/CJ.a2021.0028, indexed in Pubmed: 33645626.
  6. Coromilas EJ, Kochav S, Goldenthal I, et al. Worldwide survey of COVID-19-associated arrhythmias. Circ Arrhythm Electrophysiol. 2021; 14(3): e009458, doi: 10.1161/CIRCEP.120.009458, indexed in Pubmed: 33554620.
  7. Al-Assaf O, Mirza M, Musa A. Atypical presentation of COVID-19 as subclinical myocarditis with persistent high-degree atrioventricular block treated with pacemaker implant. HeartRhythm Case Rep. 2020; 6(11): 884–887, doi: 10.1016/j.hrcr.2020.09.003, indexed in Pubmed: 32953452.
  8. Wojewoda K, Tarkowski A, Wysokinska K, et al. Syncope due to third-degree atrioventricular block as the only manifestation of myocarditis following COVID-19 infection. Kardiol Pol. 2021; 79(11): 1296–1297, doi: 10.33963/KP.a2021.0117, indexed in Pubmed: 34599493.
  9. Eneizat Mahdawi T, Wang H, Haddadin FI, et al. Heart block in patients with coronavirus disease 2019: A case series of 3 patients infected with SARS-CoV-2. HeartRhythm Case Rep. 2020; 6(9): 652–656, doi: 10.1016/j.hrcr.2020.06.014, indexed in Pubmed: 32837907.
  10. Prasad M, Leon M, Lerman LO, et al. Viral endothelial dysfunction: a unifying mechanism for COVID-19. Mayo Clin Proc. 2021; 96(12): 3099–3108, doi: 10.1016/j.mayocp.2021.06.027, indexed in Pubmed: 34863398.