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open access

Vol 28, No 6 (2021)
Original Article
Submitted: 2021-11-29
Accepted: 2021-12-03
Published online: 2021-12-17
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Impact of COVID-19 on in-hospital cardiac arrest outcomes: An updated meta-analysis

Karol Bielski12, Katarzyna Makowska3, Adam Makowski3, Tomasz Kopiec3, Aleksandra Gasecka3, Mariola Malecka4, Michal Pruc5, Zubaid Rafique6, Frank W. Peacock6, Andrea Denegri7, Lukasz Szarpak58
DOI: 10.5603/CJ.a2021.0168
·
Pubmed: 34985120
·
Cardiol J 2021;28(6):816-824.
Affiliations
  1. Research Unit, Polonia University, Czestochowa, Poland
  2. Provincial Emergency Medical Service Dispatcher, Warsaw, Poland
  3. First Chair and Department of Cardiology, Medical University of Warsaw, Poland
  4. Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland
  5. Research Unit, Polish Society of Disaster Medicine, Warsaw, Poland
  6. Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, United States
  7. Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy
  8. Research Unit, Maria Sklodowska-Curie Bialystok Oncology Center, Bialystok, Poland

open access

Vol 28, No 6 (2021)
Original articles — COVID-19
Submitted: 2021-11-29
Accepted: 2021-12-03
Published online: 2021-12-17

Abstract

Background: The main purposes of this meta-analysis are to update the information about the impact of coronavirus disease 2019 (COVID-19) pandemic on outcomes of in-hospital cardiac arrest (IHCA) and to investigate the impact of being infected by by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) on IHCA outcomes.
Methods: The current meta-analysis is an update and follows the recommendations of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
Results: In analyses, pre- and intra-COVID-19 periods were observed for: shockable rhythms in 17.6% vs. 16.2% (odds ratio [OR]: 1.11; 95% confidence interval [CI]: 0.71–1.72; p = 0.65), return of spontaneous circulation (ROSC) in 47.4% vs. 44.0% (OR: 1.36; 95% CI: 0.90–2.07; p = 0.15), 30-day mortality in 59.8% vs. 60.9% (OR: 0.95; 95% CI: 0.75–1.22; p = 0.69) and overall mortality 75.8% vs. 74.7% (OR: 0.80; 95% CI: 0.49–1.28; p = 0.35), respectively. In analyses, SARS-CoV-2 positive and negative patients were observed for: shockable rhythms in 9.6% vs. 19.8% (OR: 0.51; 95% CI: 0.35–0.73; p < 0.001), ROSC in 33.9% vs. 52.1% (OR: 0.47; 95% CI: 0.30–0.73; p < 0.001), 30-day mortality in 77.2% vs. 59.7% (OR: 2.08; 95% CI: 1.28–3.38; p = 0.003) and overall mortality in 94.9% vs. 76.7% (OR: 3.20; 95% CI: 0.98–10.49; p = 0.05), respectively.
Conclusions: Despite ROSC, 30-day and overall mortality rate were not statistically different in pre- vs. intra-COVID-19 periods, a lower incidence of ROSC and higher 20-day mortality rate were observed in SARS-CoV-2 (+) compared to SARS-CoV-2 (–) patients.

Abstract

Background: The main purposes of this meta-analysis are to update the information about the impact of coronavirus disease 2019 (COVID-19) pandemic on outcomes of in-hospital cardiac arrest (IHCA) and to investigate the impact of being infected by by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) on IHCA outcomes.
Methods: The current meta-analysis is an update and follows the recommendations of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
Results: In analyses, pre- and intra-COVID-19 periods were observed for: shockable rhythms in 17.6% vs. 16.2% (odds ratio [OR]: 1.11; 95% confidence interval [CI]: 0.71–1.72; p = 0.65), return of spontaneous circulation (ROSC) in 47.4% vs. 44.0% (OR: 1.36; 95% CI: 0.90–2.07; p = 0.15), 30-day mortality in 59.8% vs. 60.9% (OR: 0.95; 95% CI: 0.75–1.22; p = 0.69) and overall mortality 75.8% vs. 74.7% (OR: 0.80; 95% CI: 0.49–1.28; p = 0.35), respectively. In analyses, SARS-CoV-2 positive and negative patients were observed for: shockable rhythms in 9.6% vs. 19.8% (OR: 0.51; 95% CI: 0.35–0.73; p < 0.001), ROSC in 33.9% vs. 52.1% (OR: 0.47; 95% CI: 0.30–0.73; p < 0.001), 30-day mortality in 77.2% vs. 59.7% (OR: 2.08; 95% CI: 1.28–3.38; p = 0.003) and overall mortality in 94.9% vs. 76.7% (OR: 3.20; 95% CI: 0.98–10.49; p = 0.05), respectively.
Conclusions: Despite ROSC, 30-day and overall mortality rate were not statistically different in pre- vs. intra-COVID-19 periods, a lower incidence of ROSC and higher 20-day mortality rate were observed in SARS-CoV-2 (+) compared to SARS-CoV-2 (–) patients.

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Keywords

coronavirus disease 2019, COVID-19, SARS-CoV-2, pandemic, in-hospital cardiac arrest, cardiopulmonary resuscitation, outcome, meta-analysis

About this article
Title

Impact of COVID-19 on in-hospital cardiac arrest outcomes: An updated meta-analysis

Journal

Cardiology Journal

Issue

Vol 28, No 6 (2021)

Article type

Original Article

Pages

816-824

Published online

2021-12-17

Page views

5986

Article views/downloads

629

DOI

10.5603/CJ.a2021.0168

Pubmed

34985120

Bibliographic record

Cardiol J 2021;28(6):816-824.

Keywords

coronavirus disease 2019
COVID-19
SARS-CoV-2
pandemic
in-hospital cardiac arrest
cardiopulmonary resuscitation
outcome
meta-analysis

Authors

Karol Bielski
Katarzyna Makowska
Adam Makowski
Tomasz Kopiec
Aleksandra Gasecka
Mariola Malecka
Michal Pruc
Zubaid Rafique
Frank W. Peacock
Andrea Denegri
Lukasz Szarpak

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