open access
Outcomes of the two generations of bioresorbable scaffolds (Magmaris vs. Absorb) in acute coronary syndrome in routine clinical practice


- Department of Cardiology, The Copper Health Center (MCZ), Lubin, Poland
- Department of Cardiology, Provincial Specialized Hospital, Legnica, Poland
- Adalbert’s Hospital, Poznan, Poland
- Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland
- 1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland
- Department of Internal Medicine, Hypertension and Clinical Oncology, Wroclaw Medical University, Wroclaw, Poland
open access
Abstract
Background: Acute coronary syndrome (ACS) as a clinical manifestation of coronary artery disease
(CAD) remains a significant cause of mortality and morbidity, as reported worldwide annually. The
second generation of drug-eluting stents (DES) is a gold standard in percutaneous interventions in ACS
patients however, permanent caging of the vessel with metallic DES has some drawbacks. Bioresorbable
vascular scaffolds (BRS) were designed as a temporal vessel-supporting technology allowing for anatomical
and functional restoration. Nevertheless, following the initial encouraging reports, numerous
concerns about the safety of BRS occurred.
Methods: In this study, a 1-year performance of 193 patients with magnesium BRS — Magmaris
(Biotronik, Berlin, Germany) was evaluated in comparison to 160 patients with polymer BRS —
Absorb (Abbott-Vascular, Chicago, USA) in the non-ST-segment elevation-ACS setting.
Results: The Magmaris, when compared to Absorb showed a significantly lower rate of primary
endpoint (death from cardiac causes, myocardial infarction, stent thrombosis) as well as target lesion
failure in 30-day and 1 year follow-up. In the Absorb group, a significantly higher rate of stent thrombosis
was observed.
Conclusions: Data from the present study suggests encouraging safety a profile and more favorable
clinical outcomes of magnesium BRS in comparison to the polymer Absorb — BRS.
Abstract
Background: Acute coronary syndrome (ACS) as a clinical manifestation of coronary artery disease
(CAD) remains a significant cause of mortality and morbidity, as reported worldwide annually. The
second generation of drug-eluting stents (DES) is a gold standard in percutaneous interventions in ACS
patients however, permanent caging of the vessel with metallic DES has some drawbacks. Bioresorbable
vascular scaffolds (BRS) were designed as a temporal vessel-supporting technology allowing for anatomical
and functional restoration. Nevertheless, following the initial encouraging reports, numerous
concerns about the safety of BRS occurred.
Methods: In this study, a 1-year performance of 193 patients with magnesium BRS — Magmaris
(Biotronik, Berlin, Germany) was evaluated in comparison to 160 patients with polymer BRS —
Absorb (Abbott-Vascular, Chicago, USA) in the non-ST-segment elevation-ACS setting.
Results: The Magmaris, when compared to Absorb showed a significantly lower rate of primary
endpoint (death from cardiac causes, myocardial infarction, stent thrombosis) as well as target lesion
failure in 30-day and 1 year follow-up. In the Absorb group, a significantly higher rate of stent thrombosis
was observed.
Conclusions: Data from the present study suggests encouraging safety a profile and more favorable
clinical outcomes of magnesium BRS in comparison to the polymer Absorb — BRS.
Keywords
bioresorbable scaffolds, acute coronary syndrome, magnesium scaffolds, Magmaris, Absorb, percutaneous coronary intervention


Title
Outcomes of the two generations of bioresorbable scaffolds (Magmaris vs. Absorb) in acute coronary syndrome in routine clinical practice
Journal
Issue
Article type
Original Article
Pages
870-880
Published online
2022-05-24
Page views
1799
Article views/downloads
467
DOI
Pubmed
Bibliographic record
Cardiol J 2023;30(6):870-880.
Keywords
bioresorbable scaffolds
acute coronary syndrome
magnesium scaffolds
Magmaris
Absorb
percutaneous coronary intervention
Authors
Piotr Rola
Adrian Włodarczak
Magdalena Łanocha
Mateusz Barycki
Marek Szudrowicz
Jan J. Kulczycki
Joanna Jaroszewska-Pozorska
Alicja Gosiewska
Katarzyna Woźnica
Maciej Lesiak
Adrian Doroszko


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